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Cognitive Rehab and Exposure Treatment for Hoarding (CREST Trial)

N/A

Waitlist Available

Led By Catherine R Ayers, PhD

Research Sponsored by VA Office of Research and Development

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline to 6 month-follow-up (12 months total)

Awards & highlights

No Placebo-Only Group

Summary

This trial tests two treatments for Veterans with hoarding disorder. One combines brain exercises with sorting tasks, and the other focuses on facing fears. The goal is to see which treatment better reduces symptoms and improves life quality.

Eligible Conditions

Hoarding Disorder
Obsessive Hoarding

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline to 6 month-follow-up (12 months total)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline to 6 month-follow-up (12 months total)

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to 6 month-follow-up (12 months total) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Saving Inventory Revised

Secondary study objectives

Specific Levels of Functioning Test (SLOF)

UCSD Performance-Based Skills Assessment (UPSA)

UCSD SORT Test

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Cognitive Rehabilitation and Exposure/Sorting Treatment (CREST)Experimental Treatment1 Intervention

Compensatory Cognitive Training (CCT) is a manualized, low-tech, cognitive training intervention designed to target cognitive impairments common in people with psychiatric illness. The CCT modules specifically selected for CREST map onto known areas of HD neurocognitive deficits or weakness and include training in prospective memory, prioritizing, problem solving, planning, and cognitive flexibility. Symptoms of acquiring and saving are themselves avoidance behaviors that are performed to avoid internal distress related to negative thoughts and emotions. Avoidance serves to reduce distress related to the beliefs regarding the necessity and utility of possessions. In the CREST condition, the second part and the majority of treatment is dedicated to exposure therapy (ET) for discarding and not acquiring while in the control condition, the entire treatment will consist of ET.

Group II: Exposure Therapy (ET)Active Control1 Intervention

The investigators propose to use a robust control condition, exposure therapy (ET), with the same frequency and amount of therapist contact as CREST. Twenty-six weekly, individual ET sessions (6 months) will be delivered. The control group will receive ET for all 26 sessions and no cognitive training. As in CREST, the ET sessions will be manualized and copies utilized during session by both the patient and therapist.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Cognitive Rehabilitation and Exposure/Sorting Treatment (CREST)

2015

N/A

~120

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