Dietary Capsaicin for High Blood Pressure

N/A

Recruiting

Research Sponsored by Skidmore College

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, 24 hours, and 6-weeks

Summary

This trial aims to study the effects of dietary capsaicin on cardiovascular health, specifically looking at whether these effects differ between males and females. The researchers will be investigating how capsaicin impacts

Who is the study for?

This trial is for non-smoking men and women over 18 with high blood pressure, but otherwise healthy. It's not for those with heartburn, stomach issues, food allergies, trouble swallowing pills, or a severe sensitivity to spicy foods. People with serious illnesses or uncontrolled hypertension can't join. Women who are pregnant, trying to conceive, breastfeeding or without a period (not due to birth control) are also excluded.

What is being tested?

The study tests if dietary capsaicin affects cardiovascular health differently in men and women by looking at nitric oxide levels and markers like blood pressure and arterial stiffness. Participants will take dietary capsules containing capsaicin.

What are the potential side effects?

Potential side effects may include digestive discomfort such as heartburn or upset stomach due to the spicy nature of capsaicin. Since participants with excessive sensitivity to spice are excluded from the trial, severe reactions should be uncommon.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, 24 hours, and 6-weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, 24 hours, and 6-weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, 24 hours, and 6-weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Blood Pressure and Vascular Stiffness

Flow Mediated Dilation

Heart Rate (HR) and HR variability (HRV)

+2 more

Secondary study objectives

Blood Lipids

Urinary Capsaicinoids

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Dietary CapsaicinExperimental Treatment1 Intervention

Over-the-counter dose of 2 x 440 mg capsules (880 mg, Capsicum Pepper Blend, Daily Manufacturing, Rockwell, North Carolina, USA)

Group II: PlaceboPlacebo Group1 Intervention

The placebo will be 2 x 400-500 mg fiber (800 mg psyllium husk) capsules which were chosen to be of similar appearance (size, coloration, and texture).

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