Ventilation Manipulation for Glaucoma

N/A

Recruiting

Led By Kanwal Nischal, MD,FRCOphth

Research Sponsored by University of Pittsburgh

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Any child undergoing an eye exam under anesthesia for an ophthalmologic reason

Children between the ages newborn to 8 years of age

Timeline

Screening 3 weeks

Treatment Varies

Follow Up after induction of anesthesia end tidal co2 will be manipulated to 40mmhg, then 30mmhg and then 50mmhg. the end tidal co2 levels will be held for at least 5 minutes after each ventilation manipulation;at the end of 5 minute period choroid images taken

Awards & highlights

No Placebo-Only Group

Summary

This trial aims to study how the amount of carbon dioxide in the blood and the pressure inside the eye affect the volume of a specific part of the eye using a special imaging technique during eye exams done while

Who is the study for?

This clinical trial is for children from newborns up to 8 years old who are already scheduled for an eye exam under anesthesia due to ophthalmologic reasons. It's not suitable for kids over 8, those with conditions affecting brain blood flow regulation, increased pressure inside the skull, or any issues the anesthesiologist thinks could cause problems.

What is being tested?

The study is examining how changing the amount of carbon dioxide (CO2) in a child's breath affects the thickness of part of their eye called the choroid. This will be done using special imaging during an eye exam while they're under anesthesia.

What are the potential side effects?

Since this trial involves ventilation manipulation rather than medication, side effects may include discomfort from changes in breathing patterns and potential risks associated with general anesthesia.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My child needs an eye exam under anesthesia for an eye condition.

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My child is between newborn and 8 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ after induction of anesthesia end tidal co2 will be manipulated to 40mmhg, then 30mmhg and then 50mmhg. the end tidal co2 levels will be held for at least 5 minutes after each ventilation manipulation and at the end of this 5 minute period iop measured

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~after induction of anesthesia end tidal co2 will be manipulated to 40mmhg, then 30mmhg and then 50mmhg. the end tidal co2 levels will be held for at least 5 minutes after each ventilation manipulation and at the end of this 5 minute period iop measured

This trial's timeline: 3 weeks for screening, Varies for treatment, and after induction of anesthesia end tidal co2 will be manipulated to 40mmhg, then 30mmhg and then 50mmhg. the end tidal co2 levels will be held for at least 5 minutes after each ventilation manipulation and at the end of this 5 minute period iop measured for reporting.