Dietary Oxalate Intake for Kidney Stone Prevention

Recruiting in Palo Alto (17 mi)

Overseen byTanecia Mitchell, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Alabama at Birmingham

No Placebo Group

Trial Summary

What is the purpose of this trial?

The purpose of this study is to evaluate mitochondrial function in white blood cells and platelets from healthy individuals following dietary oxalate intake.

Research Team

Tanecia Mitchell, PhD

Principal Investigator

University of Alabama at Birmingham

Eligibility Criteria

This trial is for mentally competent adults aged 18-70, with a BMI of 19-27, who don't use tobacco or vigorous exercise during the study. They must understand English consent forms and have normal blood tests. It's not for pregnant individuals, those on medications/supplements, with medical problems or history of kidney stones.

Inclusion Criteria

Willingness to abstain from vigorous exercise during study period

Non-tobacco users

I am between 18 and 70 years old.

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Exclusion Criteria

I have a condition that affects how my body absorbs or gets rid of oxalate.

I am able to understand and consent to the study on my own.

I am currently taking medications or dietary supplements.

See 5 more

Treatment Details

Interventions

Dietary Oxalate (Behavioural Intervention)

Trial OverviewThe study is testing how different drinks (kale smoothie, spinach smoothie, sodium oxalate drink) affect immune cell function in healthy people by looking at mitochondrial function in white blood cells and platelets after consuming dietary oxalate.

Participant Groups

8Treatment groups

Experimental Treatment

Group I: 5d Diet+Spinach Smoothie+BreakfastExperimental Treatment2 Interventions

5 days of prepared meals with fasting on the final day. On final day, participants will return to the study site and drink a prepared blended spinach smoothie and be provided a breakfast meal.

Group II: 3d Diet+V Spinach Smoothie+BreakfastExperimental Treatment2 Interventions

3 days of prepared meals with fasting on the final day. On final day, participants will return to the study site and drink a prepared blended spinach smoothie with varying amounts of spinach and be provided a breakfast meal.

Group III: 3d Diet+Spinach Smoothie+Breakfast w/ 24 Hr UrineExperimental Treatment2 Interventions

3 days of prepared meals with fasting on the final day. On final day, participants will return to the study site and drink a blended spinach smoothie and be provided a breakfast meal.

Group IV: 3d Diet+Spinach Smoothie+BreakfastExperimental Treatment2 Interventions

3 days of prepared meals with fasting on the final day. On final day, participants will return to study site and drink a prepared blended spinach smoothie and be provided a breakfast meal.

Group V: 3d Diet+Sodium Oxalate Drink+BreakfastExperimental Treatment2 Interventions

3 days of prepared meals with fasting on the final day. On final day, participants will return to the study site and drink a prepared sodium oxalate drink and be provided a breakfast meal.

Group VI: 3d Diet+Kale Smoothie+BreakfastExperimental Treatment2 Interventions

3 days of prepared meals with fasting on the final day. On the final day, participants will return to the study site and drink a prepared kale smoothie and be provided a breakfast meal.

Group VII: 3d Diet+BreakfastExperimental Treatment1 Intervention

3 days of prepared meals with fasting on the final day. On final day, participants will return to the study site and be provided a breakfast meal.

Group VIII: 3d Diet+Blended Smoothie+BreakfastExperimental Treatment2 Interventions

3 days of prepared meals with fasting on the final day. On final day, participants will return to the study site and drink a prepared blended smoothie and be provided a breakfast meal.