Holmium vs Thulium Lasers for Kidney Stones

Recruiting in Palo Alto (17 mi)

+5 other locations

Overseen byStephen Nakada, MD, FACS, FRCS

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Wisconsin, Madison

No Placebo Group

Trial Summary

What is the purpose of this trial?

This is a prospective randomized controlled trial designed to assess the efficacy and safety of Lumenis® Pulse™ P120H holmium laser system with the Moses technology (holmium laser with pulse modulation) versus the Soltive™ SuperPulsed Laser System with the thulium fiber laser (thulium fiber laser), in dusting of renal stones during ureteroscopy with laser lithotripsy. 310 participants will be enrolled across 5 research sites.

Eligibility Criteria

This trial is for patients with kidney stones sized between 5mm and 20mm who need laser treatment. It's not for pregnant individuals, those with transplant kidneys or certain anatomical variations, irreversible coagulopathy, ureteral strictures, non-English speakers without decision-making capacity, recent prior treatments, urothelial tumors, or specific metabolic conditions.

Inclusion Criteria

I need outpatient laser treatment for my kidney stones.

I had a kidney stone at the UPJ but it has been treated.

My kidney stone is between 5mm and 20mm in size.

See 1 more

Exclusion Criteria

You have not had a CT scan before your surgery.

I have a known narrowing of my ureters.

Pregnant patients

See 8 more

Treatment Details

Interventions

Holmium Laser with Moses Technology (Procedure)
SuperPulsed Laser System with Thulium Fiber Laser (Procedure)

Trial OverviewThe study compares two types of lasers in breaking down kidney stones during surgery: the Lumenis® Pulse™ P120H holmium laser system using Moses technology versus the Soltive™ SuperPulsed Laser System with thulium fiber laser. Participants are randomly assigned to one of these treatments at five different research sites.

Participant Groups

2Treatment groups

Active Control

Group I: Holmium laser with pulse modulationActive Control1 Intervention

Group II: Thulium fiber laserActive Control1 Intervention