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Probiotics

Fermented Foods for Post-COVID Syndrome

Rochester, MN

N/A

Waitlist Available

Led By Liousmila V Karnatovskaia, MD

Research Sponsored by Mayo Clinic

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Adults (>18 years old)

Be older than 18 years old

Must not have

Undergoing chemotherapy at the time of consent

Taking MAOIs at the time of consent

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at enrollment and completion of study (12 weeks)

Awards & highlights

No Placebo-Only Group

Summary

"This trial aims to see how eating fermented foods affects the variety of bacteria in the gut of people with long-COVID."

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Who is the study for?

This trial is for adults over 18 with long COVID, defined as having had a COVID-19 infection in the last year and experiencing neurological symptoms like fatigue or difficulty concentrating. Participants must have visited the Mayo Clinic's long-COVID Clinic and be able to use a food logging app.Check my eligibility

What is being tested?

The study aims to see if eating fermented foods can change the variety of bacteria in the gut of people with long COVID. Participants will either follow their usual diet (control group) or include fermented foods, and researchers will compare results between these two groups.See study design

What are the potential side effects?

While not explicitly listed, potential side effects may include digestive discomfort due to changes in diet when introducing fermented foods, such as bloating, gas, or altered bowel movements.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am over 18 years old.

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Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I am currently receiving chemotherapy.

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I am currently taking MAOI medications.

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I do not have active, severe digestive system conditions or recent major GI surgery.

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Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ at enrollment and completion of study (12 weeks)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~at enrollment and completion of study (12 weeks)

This trial's timeline: 3 weeks for screening, Varies for treatment, and at enrollment and completion of study (12 weeks) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Gut Microbiome diversity

Secondary study objectives

Assessment of cognition

Assessment of post-traumatic stress (PTSD) symptoms

Assessment of quality of life

+1 more

Other study objectives

Research participant's subjective assessment of study adherence

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: TreatmentExperimental Treatment1 Intervention

Will receive an in-person teaching session delivered by a trained team member including introductory education on microbiome and a description on a variety of probiotic fermented foods commercially available (fermented dairy products, fermented vegetables, fermented non-alcoholic drinks). Participants will be able to choose their own probiotic fermented foods based on this education and taste preference. Subjects will be contacted weekly to ensure they are tolerating and adhering to the study protocol.

Group II: ControlActive Control1 Intervention

The subjects in the control arm will only complete the baseline and week 13 visits. They will not be asked to make any changes to their diet, only to document their regular diet 3 days a week.

0 / 4Eligibility criteria met