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Behavioural Intervention

Geriatric Care Optimization for Blood Cancers

N/A

Waitlist Available

Led By Sarah Wall, MD

Research Sponsored by Ohio State University Comprehensive Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Diagnosed with hematologic malignancy or bone marrow failure syndrome eligible for allogeneic hematopoietic cell transplantation. This includes acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndrome, myeloproliferative neoplasm, myelofibrosis, chronic myeloid leukemia, chronic lymphocytic leukemia, non-Hodgkin lymphoma, Hodgkin lymphoma, multiple myeloma, and aplastic anemia. Disease specific eligibility for allo-HCT to be determined by treating physician

Age >= 60 years

Must not have

No possibility of proceeding to allogeneic hematopoietic cell transplant within the next 6 months as determined by treating physician

Scheduled admission for allogeneic hematopoietic cell transplant within 30 days of enrollment

Timeline

Screening 3 weeks

Treatment Varies

Follow Up at 6 months before transplant, up to 12 months after transplant

Awards & highlights

No Placebo-Only Group

Summary

This trial studies if a plan tailored to the individual can improve survival & quality of life for patients over 60 w/ hematologic malignancy or bone marrow failure syndrome receiving an allogeneic hematopoietic cell transplant.

Who is the study for?

This trial is for people over 60 with blood cancers or bone marrow failure who are eligible for a stem cell transplant. They must be able to understand English and commit to the study's full duration. Those with dementia, no transplant planned within 6 months, or a scheduled transplant within 30 days can't join.

What is being tested?

The OTIS Study tests a geriatric optimization plan (GO!) aimed at improving survival in older adults through personalized lifestyle changes like diet, sleep, activity adjustments, medication reviews, and specialist referrals before their stem cell transplants.

What are the potential side effects?

Since this trial focuses on health promotion rather than drugs or invasive procedures, side effects may include discomfort from lifestyle changes or stress from additional medical appointments and assessments.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am eligible for a stem cell transplant due to my blood-related cancer or condition.

Select...

I am 60 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I am not eligible for a bone marrow transplant from a donor within the next 6 months.

Select...

I am scheduled for a stem cell transplant from a donor within the next 30 days.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ at 6 months before transplant, up to 12 months after transplant

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~at 6 months before transplant, up to 12 months after transplant

This trial's timeline: 3 weeks for screening, Varies for treatment, and at 6 months before transplant, up to 12 months after transplant for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in 6-Minute Walk Test distance

Secondary study objectives

Adherence to prescribed geriatric optimization plan (GO!) prescription

Change in Short Physical Performance Battery score

Change in cognitive and mental health

+6 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: Supportive care (GO!)Experimental Treatment4 Interventions

Patients undergo personalized GO! plan consisting of study visits over 50 minutes at baseline and 6 months after first visit or at the time of hospital admission for bone marrow transplant and over 25 minutes at 3 and 12 months after transplant. Patients complete questionnaires once a month for up to 6 months and wear an accelerometer for up to 6 months.

0 / 4Eligibility criteria met