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Cannabinoid Receptor Agonist

Cannabis Dependent Subjects for Cannabis Dependence (Multimodal Trial)

N/A
Waitlist Available
Led By Patrick Skosnik, PhD
Research Sponsored by Yale University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change in cb1r availability from baseline to 48 hours and 28 days
Awards & highlights
No Placebo-Only Group

Summary

This trial will study the effects of cannabis use on the brain, specifically CB1R availability and neural oscillations, in order to better understand how cannabis use affects cognition.

Eligible Conditions
  • Cannabis Dependence
  • Healthy Subjects

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change in cb1r availability from baseline to 48 hours and 28 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and change in cb1r availability from baseline to 48 hours and 28 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
CB1R availability using [11-C]OMAR PET imaging
Secondary study objectives
Changes in Cognition during withdrawal using a computerized battery
Changes in brain rhythms measured by Electroencephalography

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Healthy ControlsExperimental Treatment1 Intervention
Subjects with no current cannabis use
Group II: Cannabis Dependent SubjectsExperimental Treatment1 Intervention
Subjects who are frequent cannabis users
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
[11-C]OMAR
2016
N/A
~170

Find a Location

Who is running the clinical trial?

Yale UniversityLead Sponsor
1,913 Previous Clinical Trials
3,039,320 Total Patients Enrolled
3 Trials studying Cannabis Dependence
219 Patients Enrolled for Cannabis Dependence
National Institute on Drug Abuse (NIDA)NIH
2,568 Previous Clinical Trials
3,285,441 Total Patients Enrolled
28 Trials studying Cannabis Dependence
3,425 Patients Enrolled for Cannabis Dependence
Patrick Skosnik, PhDPrincipal InvestigatorYale University
~18 spots leftby Oct 2025
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