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Phenolic Compound
Oleocanthal-Rich Olive Oil for Platelet Aggregation
N/A
Recruiting
Research Sponsored by University of California, Davis
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, 2, 4 and 6 hours
Awards & highlights
Study Summary
This trial will observe the effects of oleocanthal-rich olive oil on platelet function over a 6 hour period.
Who is the study for?
This trial is for men and women aged 20-45, with a BMI of 18.5-30 kg/m2, who can follow the study plan. Men must weigh at least 110 pounds; women need regular menstrual cycles. Excluded are those with blood disorders, under medical supervision, on certain medications or diets, or with allergies to olives/oil.Check my eligibility
What is being tested?
The study tests how two types of extra virgin olive oil (one low in oleocanthal and one rich in it) affect platelet function when consumed with food over different times compared to fasting overnight.See study design
What are the potential side effects?
While not explicitly listed in the provided information, potential side effects may include digestive discomfort due to olive oil intake and possible changes in blood parameters related to platelet function.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline, 2, 4 and 6 hours
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, 2, 4 and 6 hours
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Influence of Oleocanthal-rich EVOO intake on Collagen-induced platelet aggregometry
Secondary outcome measures
Influence of Oleocanthal-rich EVOO intake on Adenosine Diphosphate-induced platelet aggregometry
Arachidonic acid
Influence of Oleocanthal-rich EVOO intake on Metabolomics
+1 moreTrial Design
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Oleocanthal-Rich Extra Virgin Olive OilExperimental Treatment2 Interventions
Extra Virgin Olive Oil that is high in the phenolic oleocanthal, but contains similar amounts of total phenolics as the Oleocanthal-Low Extra Virgin Olive Oil
Group II: Oleocanthal-Low Extra Virgin Olive OilPlacebo Group2 Interventions
Extra Virgin Olive Oil that is low in the phenolic oleocanthal, but contains similar amounts of total phenolics as the Oleocanthal-Rich Extra Virgin Olive Oil
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Who is running the clinical trial?
University of California, DavisLead Sponsor
914 Previous Clinical Trials
4,720,665 Total Patients Enrolled
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Eligibility Criteria:
This trial includes the following eligibility criteria:- You follow a vegetarian, vegan, or non-traditional diet, or are currently trying to lose weight.You are allergic to or cannot tolerate ibuprofen.Your body mass index (BMI) is between 18.5 and 30, which means you have a healthy weight.You have a body mass index (BMI) of 31 or higher.You have a condition that causes problems with bleeding.You have difficulty digesting or absorbing nutrients from food, which can cause symptoms like bloating, cramping, or gas.You have shown signs of using drugs or alcohol excessively in the past three years.You are allergic to olives or olive oil.You cannot eat olive oil for 4 weeks before and during the study.You are currently using prescription drugs or supplements.You are okay with drinking a small amount of olive oil, about 2 tablespoons.You have had heart problems, stroke, cancer, kidney, liver, or thyroid disease, gastrointestinal (digestive) issues, or previous gastrointestinal surgery.You are not willing to stop taking any supplements, like herbal or fish oil, for at least six weeks before starting the study.
Research Study Groups:
This trial has the following groups:- Group 1: Oleocanthal-Low Extra Virgin Olive Oil
- Group 2: Oleocanthal-Rich Extra Virgin Olive Oil
Awards:
This trial has 0 awards, including:Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
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