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Behavioural Intervention

Deep TMS for Methamphetamine Addiction

N/A

Waitlist Available

Led By Claudia B Padula, PhD

Research Sponsored by Stanford University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Must be within the age range of 25-75

Participants must be able to read, verbalize, understand, and voluntarily sign the Informed Consent Form prior to participation in study procedures in English

Must not have

Recent suicide attempt within the last 30 days or presence of current suicidal plan or intent. Patients at risk for suicide will be required to establish a written safety plan involving their primary therapist before entering the study

Acute or unstable chronic illness

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 months post-treatment

Summary

This trial will test if deep transcranial magnetic stimulation (dTMS) can help Veterans with a methamphetamine addiction.

Who is the study for?

This trial is for veterans struggling with methamphetamine addiction. Participants should be seeking treatment and have no other major health issues that could interfere with the study.

What is being tested?

The study tests deep transcranial magnetic stimulation (dTMS) using an H4 coil. Some participants will receive real dTMS, while others get a sham (fake) treatment to compare outcomes.

What are the potential side effects?

dTMS may cause discomfort at the site of stimulation, headache, lightheadedness, or seizures in very rare cases. Most side effects are mild and temporary.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 25 and 75 years old.

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I can read, understand, and sign the consent form in English.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have not attempted suicide nor planned it in the last 30 days.

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I do not have any sudden or severe ongoing illnesses.

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I am taking medication that affects seizure risk.

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I cannot stop taking my seizure-risk medication safely before treatment.

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I have a history of bipolar disorder or psychosis.

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I have a brain tumor, stroke, or another active brain condition.

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I have had a brain injury with unconsciousness for more than 10 minutes.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 months post-treatment

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 months post-treatment

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months post-treatment for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Insula Function

Percentage of Days Abstinent

Secondary study objectives

Binary Relapse

Other Salience Network Function

Resting-State Salience Network

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Active dTMSExperimental Treatment1 Intervention

Participants will receive 30 active dTMS treatments, administered 3 times per day over 10 consecutive business days. Each treatment visit will last approximately 30 minutes in total.

Group II: Sham dTMSPlacebo Group1 Intervention

Participants will receive 30 sham dTMS sessions, administered 3 times per day over 10 consecutive business days. Each treatment visit will last approximately 30 minutes in total.

0 / 9Eligibility criteria met