Resistance Training for Muscle Growth
(SLML Trial)

Recruiting in Palo Alto (17 mi)

Overseen byDr. Cameron Mitchell

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of British Columbia

No Placebo Group

Trial Summary

What is the purpose of this trial?The goal of this clinical trial is to learn the effect of applying peak force/resistance to skeletal muscles during resistance exercise training in young and healthy adults. Participants will undergo two types of resistance training conditions that are randomly assigned to the left arm and leg and the right arm and leg. The LONG condition refers to Prime Fitness machines set to setting number '3' which applies peak force at a long muscle length. The SHORT condition refers to Prime Fitness machines set to setting number '2' which applies peak force at a short muscle length. The main questions the trial aims to answer are: 1. Does applying peak force at a longer or shorter muscle length during resistance exercise training result in greater muscle growth? 2. Does applying peak force at a longer or shorter muscle length during resistance exercise training result in greater muscle growth? We hypothesize that: 1. LONG will induce greater hypertrophy compared to SHORT conditions 2. LONG will result in greater increases in 1RM strength compared to SHORT 3. LONG and SHORT training will result in angle specific increases in isokinetic strength 4. Muscle oxygenation will decline to a greater degree during LONG compared to SHORT exercise and this will be maintained between weeks 1 and 12 of training The investigators will compare the change in muscle volume and muscular strength between the LONG and SHORT training conditions, which each participant will have the left arm and leg as well as the right arm and leg randomly assigned to either exclusively LONG or SHORT conditions. Participants will: * Resistance train the left and right arm and leg with two separate conditions; LONG and SHORT for 12 weeks, with the first and last weeks dedicated to only strength testing (Isotonic and Isokinetic) and measuring muscle volume via magnetic resonance imaging (MRI) * Visit the gym for resistance training 2 times per week * Visit the UBC MRI Research Facility in weeks 1 and 12 for MRI of muscle volume

Eligibility Criteria

This trial is for young, healthy adults interested in muscle growth. Participants will engage in resistance training and undergo strength testing. They must be available to train twice a week for 12 weeks and visit the UBC MRI Research Facility at the beginning and end of the study.

Inclusion Criteria

My sex does not limit my eligibility.

Able to understand and communicate in English

I am between 19 and 30 years old.

+2 more

Exclusion Criteria

BMI lower than 18 or greater than 30

Any medical condition impacting the ability to participate in maximal exercise

I have diabetes.

+9 more

Participant Groups

The trial tests two resistance training conditions: LONG (peak force at long muscle length) and SHORT (peak force at short muscle length). It aims to determine which condition leads to greater muscle hypertrophy and strength gains using Prime Fitness machines set differently.

1Treatment groups

Experimental Treatment

Group I: SHORT and LONG Training ProtocolExperimental Treatment4 Interventions

Using a within subject design, participants will have the arms and legs from both left and right side of the body (divided by sagittal plane) randomly assigned to either LONG or SHORT conditions. Participants will then engage in maximal strength testing on Prime Fitness machines (1RM) as well as isokinetic strength testing (Biodex) in weeks 1 and 12. Participants will engage in the LONG and SHORT training sessions for 10 weeks in duration from week 2 until week 11.