Trial Summary
What is the purpose of this trial?This phase I/II trial studies the side effects and the best dose of stereotactic radiosurgery and to see how well it works in treating patients with large brain metastases. Radiosurgery can send x-rays directly to the tumor and cause less damage to normal tissue.
Eligibility Criteria
This trial is for patients with large brain metastases from solid tumors, excluding small cell lung cancer, lymphoma, and germ cell cancers. Participants must have lesions 2-4 cm in diameter suitable for stereotactic radiosurgery (SRS), may have had previous SRS or whole brain radiation therapy over 3 months ago, and be able to consent.Inclusion Criteria
My cancer is not small cell lung cancer, lymphoma, or germ cell.
Patient must be able to provide written informed consent
I am receiving SRS treatment for brain cancer spread.
+3 more
Exclusion Criteria
My radiation treatment plan doesn't meet specific uniformity criteria.
My cancer is not located in the brainstem.
My cancer is not small cell lung cancer, lymphoma, or germ cell.
+6 more
Participant Groups
The study is testing the safety and optimal dose of stereotactic radiosurgery—a precise form of radiation therapy—for treating large brain metastases. It also examines how well it works by assessing quality-of-life and cognitive functions before and after treatment.
1Treatment groups
Experimental Treatment
Group I: Treatment (SRS)Experimental Treatment3 Interventions
Patients undergo SRS guided by CT and MRI.
Stereotactic Radiosurgery is already approved in European Union, United States, Canada, Japan, China, Switzerland for the following indications:
🇪🇺 Approved in European Union as Stereotactic Radiosurgery for:
- Brain tumors
- Metastatic brain tumors
- Arteriovenous malformations (AVMs)
- Trigeminal neuralgia
- Acoustic neuromas
🇺🇸 Approved in United States as Stereotactic Radiosurgery for:
- Brain tumors
- Metastatic brain tumors
- Arteriovenous malformations (AVMs)
- Trigeminal neuralgia
- Acoustic neuromas
- Liver tumors
- Lung tumors
- Spinal cord tumors
🇨🇦 Approved in Canada as Stereotactic Radiosurgery for:
- Brain tumors
- Metastatic brain tumors
- Arteriovenous malformations (AVMs)
- Trigeminal neuralgia
- Acoustic neuromas
🇯🇵 Approved in Japan as Stereotactic Radiosurgery for:
- Brain tumors
- Metastatic brain tumors
- Arteriovenous malformations (AVMs)
- Trigeminal neuralgia
- Acoustic neuromas
🇨🇳 Approved in China as Stereotactic Radiosurgery for:
- Brain tumors
- Metastatic brain tumors
- Arteriovenous malformations (AVMs)
- Trigeminal neuralgia
- Acoustic neuromas
🇨🇭 Approved in Switzerland as Stereotactic Radiosurgery for:
- Brain tumors
- Metastatic brain tumors
- Arteriovenous malformations (AVMs)
- Trigeminal neuralgia
- Acoustic neuromas
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer CenterCleveland, OH
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Who Is Running the Clinical Trial?
Case Comprehensive Cancer CenterLead Sponsor