Carbohydrates for Running Performance
Recruiting in Palo Alto (17 mi)
Age: 18 - 65
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: University of Georgia
Must not be taking: Metabolic rate, Hydration altering
Disqualifiers: Low carbohydrate diet, Chronic diseases, others
No Placebo Group
Trial Summary
What is the purpose of this trial?Carbohydrates serve as the body's primary energy source during intense exercise, and consuming carbohydrates during exercise has been shown to improve exercise performance. Previous research has shown that the presence of carbohydrates in the mouth activates sweet taste receptors on the tongue, which signal the brain to increase neural activation in areas associated with motor functioning, sensory perception, and reward centers during exercise through this CPR. The primary objective of this intervention is to establish how carbohydrates delivered in different forms (MR versus dissolvable strip (DS)) affect running performance during a 12.8km running TT.
Will I have to stop taking my current medications?
The trial requires that you stop taking medications that could alter your metabolic rate or hydration status.
What data supports the effectiveness of the treatment Carbohydrate Mouth Rinse for running performance?
Some studies suggest that rinsing the mouth with a carbohydrate solution can improve performance in activities like cycling by opposing performance declines seen with water rinses. However, the benefits for running performance are not clearly supported, as one study found no significant improvement in running and jumping tasks with carbohydrate mouth rinse.
12345Is carbohydrate mouth rinse safe for humans?
Carbohydrate mouth rinses are generally considered safe for humans, but high intake of sports drinks containing carbohydrates can lead to dental issues and health concerns like obesity and diabetes.
12567How is the Carbohydrate Dissolvable Strip and Mouth Rinse treatment unique for running performance?
The Carbohydrate Mouth Rinse is unique because it involves swishing a carbohydrate solution in the mouth, which may enhance performance by activating receptors in the mouth that signal the brain, potentially improving endurance without needing to ingest the carbohydrates.
13589Eligibility Criteria
This trial is for men and women aged 18-45 with a normal BMI, who are endurance-trained athletes regularly training at least 4 times a week. Women must be in the early phase of their menstrual cycle to participate. Individuals over 35 need to pass a fitness safety questionnaire.Inclusion Criteria
I am between 18 and 45 years old.
I am either male or female.
I am over 35 and have passed a fitness readiness test.
+3 more
Exclusion Criteria
Donation of blood in the 20 days prior to testing
I am over 35 and failed the PARQ2 fitness test.
Low carbohydrate diet (such as The Zone™ Diet or Atkins™ Diet)
+7 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
1 week
1 visit (in-person)
Baseline Visit
Participants sign informed consent documents, undergo anthropometric measurements, and familiarize with the MR and DS and the exercise protocol
1 day
1 visit (in-person)
Treatment
Participants perform a 12.8 km running time trial on a motorized treadmill with different carbohydrate treatments
3 weeks
3 visits (in-person)
Follow-up
Participants are monitored for safety and effectiveness after treatment
1 week
Participant Groups
The study tests how different carbohydrate delivery methods (a dissolvable strip versus mouth rinse) affect running performance during a nearly 8-mile run. It explores if carbs can boost energy by activating taste receptors that signal the brain.
3Treatment groups
Experimental Treatment
Active Control
Placebo Group
Group I: Carbohydrate Dissolvable StripExperimental Treatment1 Intervention
Subjects will be instructed to complete the 12.8 km time trial (TT) as quickly as possible. They will be able to adjust the speed on the treadmill throughout the TT but will have no knowledge of what speed they are actually running at. The researcher will monitor the progress of the TT, and the completion time will be recorded. The carbohydrate dissolvable strip treatment will be given just before the start of the TT and every 12.5% of the TT, but not after the completion of the TT.
Group II: Carbohydrate Mouth RinseActive Control1 Intervention
Subjects will be instructed to complete the 12.8 km time trial (TT) as quickly as possible. They will be able to adjust the speed on the treadmill throughout the TT but will have no knowledge of what speed they are actually running at. The researcher will monitor the progress of the TT, and the completion time will be recorded. The carbohydrate mouth rinse treatment will be given just before the start of the TT and every 12.5% of the TT, but not after the completion of the TT.
Group III: Water Mouth RinsePlacebo Group1 Intervention
Subjects will be instructed to complete the 12.8 km time trial (TT) as quickly as possible. They will be able to adjust the speed on the treadmill throughout the TT but will have no knowledge of what speed they are actually running at. The researcher will monitor the progress of the TT, and the completion time will be recorded. The water mouth rinse treatment will be given just before the start of the TT and every 12.5% of the TT, but not after the completion of the TT.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
University of GeorgiaAthens, GA
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Who Is Running the Clinical Trial?
University of GeorgiaLead Sponsor
References
Carbohydrate mouth rinsing has no effect on power output during cycling in a glycogen-reduced state. [2022]The effect of mouth rinsing with a carbohydrate (CHO) solution on exercise performance is inconclusive with no benefits observed in the fed state. This study examined the effect of CHO mouth rinse or CHO ingestion on performance in 9 moderately trained male cyclists.
Opposition of carbohydrate in a mouth-rinse solution to the detrimental effect of mouth rinsing during cycling time trials. [2022]Studies have reported that rinsing the mouth with a carbohydrate (CHO) solution improves cycling time-trial performance compared with rinsing with a placebo solution. However, no studies have compared the effect of mouth rinsing with a no-mouth-rinse control condition. The aim of this study was to compare the effects of a CHO mouth rinse with those of a placebo rinse and a no-rinse condition. Ten male cyclists completed three 1,000-kJ cycling time trials in a randomized, counterbalanced order. At every 12.5% of the time trial completed, participants were required to rinse their mouths for 5 s with either a 6.4% maltodextrin solution (CHO), water (WA), or no solution (CON). Heart rate and ratings of perceived exertion (RPE) were recorded every 25% of the time trial completed. Time to completion was faster in both CHO (65.7 ± 11.07 min) and CON (67.6 ± 12.68 min) than in WA (69.4 ± 13.81 min; p = .013 and p = .042, respectively). The difference between CHO and CON approached significance (p = .086). There were no differences in heart rate or RPE between any conditions. In summary, repeated mouth rinsing with water results in decreased performance relative to not rinsing at all. Adding CHO to the rinse solution appears to oppose this fall in performance, possibly providing additional benefits to performance compared with not rinsing the mouth at all. This brings into question the magnitude of the effect of CHO mouth rinsing reported in previous studies that did not include a no-rinse condition.
Influence of carbohydrate mouth rinsing on running and jumping performance during early morning soccer scrimmaging. [2016]Carbohydrate mouth rinse (CMR) is a novel method proposed to enhance endurance performance lasting ≤ 60 min. The current study examined the influence of CMR on anaerobic performance tasks in 11 collegiate female soccer players after an overnight fast. Athletes completed two experimental sessions, during which carbohydrate (CHO; 6% maltodextrin) or taste- and colour-matched placebo (PLA) mouth-rinse solutions were administered in a counterbalanced, double-blinded design. Three rounds of a 5-min scrimmage bout and series of performance tests including a single countermovement vertical jump (1VJ), a set of four consecutive vertical jumps, a 72-m shuttle run (SR72) and 18-m sprint comprised each trial. Thirst sensation (TS), session TS, ratings of perceived exertion (RPE) and session RPE were assessed as secondary outcomes. The first SR72 approached significance (p = 0.069), but no significant between-trials differences were observed for any of the mean performance tasks. The highest 1VJ scores did not differ for the first (CHO = 47.3 ± 3.4, PLA = 47.7 ± 3.5 cm; p = 0.43), second (CHO = 48.0 ± 4.1, PLA = 47.9 ± 3.5 cm; p = 0.82) or third bout (CHO = 47.4 ± 3.9, PLA = 48.1 ± 3.9 cm; p = 0.26). TS approached significance (p = 0.053) during the first bout. No significant differences (p > 0.05) were found for any of the perceptual variables. Current results fail to support ergogenic influence of CMR on anaerobic performance tasks in collegiate female athletes.
Mouth rinsing with a carbohydrate solution attenuates exercise-induced decline in executive function. [2022]A decline in executive function could have a negative influence on the control of actions in dynamic situations, such as sports activities. Mouth rinsing with a carbohydrate solution could serve as an effective treatment for preserving the executive function in exercise. The purpose of this study was to examine the effects of mouth rinsing with a carbohydrate solution on executive function after sustained moderately high-intensity exercise.
Carbohydrate mouth rinse improves cycling performance carried out until the volitional exhaustion. [2019]Carbohydrates (CHO) are among the most investigated nutritional ergogenic aids, and may be consumed in different forms, e.g., mouth rinse with carbohydrate solution (MRCS). In this sense, the aim of this study was to evaluate the impact of MRCS on the performance of physically active individuals undergoing a physical exercise session carried out until the volitional exhaustion.
Sports drinks and dental erosion. [2011]Sports drinks were originally developed to improve hydration and performance in athletes taking part in intense or endurance sporting events. These drinks contain relatively high amounts of carbohydrates (sugars), salt, and citric acid. These ingredients create the potential for dental ramifications and overall public health consequences such as obesity and diabetes. High intake of sports drinks during exercise, coupled with xerostomia from dehydration, may lead to the possibility of erosive damage to teeth.
Maltodextrin-Based Carbohydrate Oral Rinsing and Exercise Performance: Systematic Review and Meta-Analysis. [2022]Carbohydrates are an important fuel for optimal exercise performance during moderate- and high-intensity exercise; however, carbohydrate ingestion during high-intensity exercise may cause gastrointestinal upset. A carbohydrate oral rinse is an alternative method to improve exercise performance in moderate- to high-intensity exercise with a duration of 30-75 min. This is the first systematic review and meta-analysis to comprehensively examine the isolated effect of maltodextrin-based rinsing on exercise performance.
Effects of Carbohydrate Mouth Rinse on Cycling Time Trial Performance: A Systematic Review and Meta-Analysis. [2021]Despite the growing number of studies reporting carbohydrate mouth rinse effects on endurance performance, no systematic and meta-analysis review has been conducted to elucidate the level of evidence of carbohydrate mouth rinse effects on cycling trial performance such as time-, work-, and distance-based trials.
Effects of Carbohydrate Mouth Rinsing on Salivary Lysozyme, Mood States and Running Performance Among Recreational Runners. [2022]Carbohydrate (CHO) mouth rinsing can enhance sports performance through a central action mediated by receptors in the mouth. This study examined the effect of a CHO mouth rinse on salivary lysozyme concentrations, mood states and running performances.