Trial Summary
What is the purpose of this trial?The goal of this study is to pilot test a novel group therapy intervention for adults with OCD.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications.
What data supports the effectiveness of the treatment ERP Plus Improv Group Therapy for OCD?
Exposure and response prevention (ERP) therapy is a well-established treatment for OCD, showing significant reductions in symptoms in various studies. Additionally, cognitive-behavioral therapy (CBT), which includes ERP, is effective for OCD, and incorporating cognitive therapy can improve treatment adherence and outcomes.
12345How is the ERP Plus Improv treatment for OCD different from other treatments?
ERP Plus Improv is unique because it combines traditional Exposure and Response Prevention Therapy, which helps patients face their fears without performing compulsive behaviors, with improvisational comedy, which encourages creativity and spontaneity, potentially making the therapy more engaging and enjoyable.
678910Eligibility Criteria
This trial is for adults over 18 who can speak and understand English and have been diagnosed with Obsessive-Compulsive Disorder (OCD). It's not suitable for individuals currently having suicidal thoughts or those with medical or psychiatric conditions that could affect their participation.Inclusion Criteria
Ability to speak and understand English
I am 18 years old or older.
I have been diagnosed with obsessive-compulsive disorder.
Exclusion Criteria
Current active suicidality
Medical or psychiatric illness that could interfere with study participation
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Treatment
Participants attend 90-minute ERP + improv group therapy sessions for 12 consecutive weeks, complete homework, answer questions, and complete questionnaires.
12 weeks
12 visits (in-person)
Follow-up
Participants are monitored for safety and effectiveness after treatment
4 weeks
Participant Groups
The study is testing a new group therapy method that combines Exposure Response Prevention (ERP) with improvisational group psychotherapy to see if it helps people with OCD.
1Treatment groups
Experimental Treatment
Group I: ERP combined with Improv Group TherapyExperimental Treatment2 Interventions
Participants will attend 90-minute ERP + improv group therapy sessions for 12 consecutive weeks. They will also complete homework between sessions, answer questions, and complete questionnaires.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
401 QuarryStanford, CA
Loading ...
Who Is Running the Clinical Trial?
Stanford UniversityLead Sponsor
References
Home-based behavior therapy for obsessive-compulsive disorder: a case series with data. [2019]The effectiveness of "home-based" exposure and response prevention was assessed in a series of 11 subjects with obsessive-compulsive disorder (OCD). Patients received 24 treatment sessions in a range of natural settings and situations. Sixty-four percent of the patients responded to behavior therapy in these settings, and 36% achieved lasting improvements in their OCD symptoms. Implications for the impact on consumers of this seldom-used application of behavior therapy are discussed and some recommendations for future research are made.
Acceptability, Feasibility, and Effectiveness of Internet-Based Cognitive-Behavioral Therapy for Obsessive-Compulsive Disorder in New York. [2020]Cognitive-behavioral therapy (CBT), consisting of exposure and response prevention (EX/RP), is both efficacious and preferred by patients with obsessive-compulsive disorder (OCD), yet few receive this treatment in practice. This study describes the implementation of an Internet-based CBT program (ICBT) developed in Sweden in individuals seeking OCD treatment in New York. After translating and adapting the Swedish ICBT for OCD, we conducted an open trial with 40 adults with OCD. Using the RE-AIM implementation science framework, we assessed the acceptability, feasibility, and effectiveness of ICBT. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was the primary outcome measure. Of 40 enrolled, 28 participants completed the 10-week ICBT. In the intent-to-treat sample (N = 40), Y-BOCS scores decreased significantly over time (F = 28.12, df = 2, 49, p
Effectiveness of exposure and ritual prevention for obsessive-compulsive disorder: randomized compared with nonrandomized samples. [2009]The efficacy of exposure and ritual prevention (EX/RP) for reducing symptoms of obsessive-compulsive disorder (OCD) has been demonstrated in several randomized controlled trials (RCTs). However, procedures used in these studies to maximize experimental control may have limited their generalizability to typical clinical practice. Treatment outcome data from 110 clinical patients receiving EX/RP on an outpatient fee-for-service basis were compared with findings from 4 RCTs of EX/RP. Adult patients in the clinical sample were not excluded because of treatment history, concomitant pharmacotherapy, psychiatric comorbidity, age, or OCD severity. Clinical patients achieved substantial and clinically meaningful reductions in their OCD and depressive symptoms following EX/RP, which were comparable with those reported in the RCTs. Findings indicate that EX/RP is a potent treatment for OCD, and its benefits are not limited to select patient samples.
Efficacy of cognitive-behavioral therapy for obsessive-compulsive disorder. [2022]Cognitive-behavioral therapy (CBT), which encompasses exposure with response prevention (ERP) and cognitive therapy, has demonstrated efficacy in the treatment of obsessive-compulsive disorder (OCD). However, the samples studied (reflecting the heterogeneity of OCD), the interventions examined (reflecting the heterogeneity of CBT), and the definitions of treatment response vary considerably across studies. This review examined the meta-analyses conducted on ERP and cognitive therapy (CT) for OCD. Also examined was the available research on long-term outcome associated with ERP and CT. The available research indicates that ERP is the first line evidence based psychotherapeutic treatment for OCD and that concurrent administration of cognitive therapy that targets specific symptom-related difficulties characteristic of OCD may improve tolerance of distress, symptom-related dysfunctional beliefs, adherence to treatment, and reduce drop out. Recommendations are provided for treatment delivery for OCD in general practice and other service delivery settings. The literature suggests that ERP and CT may be delivered in a wide range of clinical settings. Although the data are not extensive, the available research suggests that treatment gains following ERP are durable. Suggestions for future research to refine therapeutic outcome are also considered.
[Psychotherapeutic care in OCD outpatients--results from an anonymous therapist survey]. [2022]The aim of the present study was to investigate the actual psychotherapeutic care in OCD outpatients. All psychotherapeutic members of the Südbaden Association Of Statutory Health (n=386) were contacted to fill in an anonymous questionnaire regarding frequency of treatment and treatment strategies in OCD. Particularly, the application of exposure therapy was asked. Answers were analysed descriptively. 177 therapists (45%) took part in the study. In average, psychotherapists treated about 3 patients with OCD in 2006. 86.7% of the therapists estimated the treatment of OCD as being of no relevance or only of little relevance in their daily practice. Exposure treatment was used by less than half of the therapists. The most frequent reason for avoidance of exposure treatment was a lack of experience or insufficient training in this technique. Results suggest a need for optimization of OCD outpatient care, especially with regard to application of treatment strategies with scientific evidence.
Evidence-based review of lasers, light sources and photodynamic therapy in the treatment of acne vulgaris. [2018]Background There is a considerable need for effective and safe treatment for acne vulgaris. Objective In a systematic review with an evidence-based approach to assess the effects of optical treatments for acne vulgaris. Methods Original publications of controlled clinical trials were identified through searches in PubMed and the Cochrane Library. Results A total of 16 randomized controlled trials (RCT) and 3 controlled trials (CT) were identified, involving a total of 587 patients. Interventions included photodynamic therapy (PDT; 5 RCTs), infrared lasers (4 RCTs), broad-spectrum light sources (3 RCTs, 1 CT), pulsed dye lasers (PDL; 2 RCTs, 1 CT), intense pulsed light (IPL; 1 RCTs, 2 CTs), and potassium titanyl phosphate laser (1 RCT). The randomization method was mentioned in 6 of 16 RCTs, and one trial described adequate allocation concealment. Most trials were intraindividual trials (12 of 19), which applied blinded response evaluations (12 of 19) and assessed a short-term efficacy up to 12 weeks after treatment (17 of 19). Based on the present best available evidence, we conclude that optical treatments possess the potential to improve inflammatory acne on a short-term basis with the most consistent outcomes for PDT [up to 68% improvement, aminolevulinic acid (ALA), methyl-aminolevulinic acid (MAL) and red light]. IPL-assisted PDT seems to be superior to IPL alone. Only two trials compare optical vs. conventional treatments, and further studies are needed. Side-effects from optical treatments included pain, erythema, oedema, crusting, hyperpigmentation, pustular eruptions and were more intense for treatments combined with ALA or MAL. Conclusion Evidence from controlled clinical trials indicates a short-term efficacy from optical treatments for acne vulgaris with the most consistent outcomes for PDT. We recommend that patients are preoperatively informed of the existing evidence, which indicates that optical treatments today are not included among first line treatments.
Physicians' opinions on partner management for nonviral sexually transmitted infections. [2015]Patient-delivered therapy (PDT) for nonviral sexually transmitted infections (STIs) is the practice of dispensing or prescribing medication to patients for their sex partners. While this practice is effective in preventing re-infection in patients, its use is not widespread. The purpose of this survey was to assess physicians' PDT practices and opinions toward potential benefits and perceived barriers associated with PDT.
The practicalities of photodynamic therapy in acne vulgaris. [2009]A staple clinical skill in a dermatologist's repertoire is the ability to treat acne vulgaris effectively. Light-based therapies such as photodynamic therapy (PDT) widen the therapeutic options available for acne. Numerous review articles have agreed on the answer to core questions such as: 'Does PDT work?' and 'Which acne lesions respond best to PDT?' They conclude that PDT is especially useful in inflammatory acne and may be superior to light therapy alone. This literature review seeks to offer guidance regarding treatment-specific queries about the photosensitizer, route of administration, treatment intervals, light sources and patient selection. Ovid Medline, PubMed and EMBASE database searches were executed between January 2007 and March 2008. Due to the scarcity of data, all five randomized trials, four of which were at least investigator blinded and controlled, 12 open clinical studies, two case reports and two abstracts published in English were considered. Four hundred and nineteen patients were recruited. As the quality of the data was suboptimal in a significant number of articles, the conclusions are drawn in very broad strokes: topical short-contact (90 min or less) 5-aminolaevulinic acid or methyl aminolaevulinate using a noncoherent light source at 2-4-week intervals for a total of two to four treatments produces the greatest clinical effect. Papulopustular acne is more responsive and all Fitzpatrick skin types are eligible. However, patients with skin types I-III have a reduced risk of postinflammatory hyperpigmentation seen in darker skin types. These treatment parameters demonstrate a good side-effect profile resulting in acne remission for at least 3 months to a year in a relatively cost-effective manner. Well-designed nonsplit-face randomized controlled trials would offer further guidance, especially for queries surrounding the light source and illumination schemes.
Efficacy of photodynamic therapy combined with minocycline for treatment of moderate to severe facial acne vulgaris and influence on quality of life. [2022]Acne vulgaris is a prevalent skin disorder impairing both physical and psychosocial health. This study was designed to investigate the effectiveness of photodynamic therapy (PDT) combined with minocycline in moderate to severe facial acne and influence on quality of life (QOL).
Photodynamic therapy for subungual Bowen's disease. [2016]A 35-year-old police shooting instructor with a 4-year history of Bowen's disease of the nail bed on his right index finger confirmed histologically, was successfully treated with photodynamic therapy (PDT). Four cycles of PDT were used with two different photosensitizers: 20% 5-amino-levulinic acid oil in water emulsion and methyl amino-levulinate (Metvix) cream. The lesion was successfully treated with clinical and histological clearance. There was minimal loss of time from work, with neither functional nor cosmetic deficits.