Deep Brain Stimulation for OCD
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores a new treatment for individuals with treatment-resistant OCD (Obsessive-Compulsive Disorder) using a device called deep brain stimulation (DBS). The researchers aim to understand the relationship between brain activity and OCD behaviors, both in a controlled clinic environment and in everyday life at home. They will observe participants at different stages to assess how their brains respond to DBS and how it affects their OCD symptoms. This trial may suit adults who have had OCD for at least five years, tried several medications and therapies without success, and are considering surgery as a treatment option. As a Phase 2 trial, this research focuses on measuring the treatment's effectiveness in an initial, smaller group of people, offering participants a chance to contribute to the development of a potentially effective treatment.
Will I have to stop taking my current medications?
The trial requires that your current psychotropic medications remain stable for at least one month before surgery. This means you should not change your medication regimen during that time.
What prior data suggests that this device is safe for patients with OCD?
Research has shown that deep brain stimulation (DBS) has been used in people with obsessive-compulsive disorder (OCD) who haven't responded to other treatments, yielding promising results. Some studies indicate that DBS can reduce OCD symptoms by about 40%, suggesting it might help those who haven't found relief with other methods.
Regarding safety, DBS is generally well-tolerated. Studies have found that DBS can ease OCD symptoms and even help with depression in some patients. However, like any medical procedure, there can be risks. Some patients have experienced side effects, but these are often manageable.
In summary, studies have shown DBS to be both effective and tolerable for people with severe OCD. Prospective trial participants should discuss the potential risks and benefits with their healthcare provider.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it explores how neuromodulation might offer new hope for patients with treatment-resistant Obsessive-Compulsive Disorder (OCD). Unlike current treatments, which often rely on medications like SSRIs or cognitive-behavioral therapy, this approach targets the brain's approach-avoidance axis directly. By understanding and potentially altering this neural circuitry, the trial aims to offer relief to those who haven't responded to existing therapies. This could pave the way for more personalized and effective interventions for OCD.
What evidence suggests that Deep Brain Stimulation might be an effective treatment for OCD?
Research has shown that deep brain stimulation (DBS), currently under study in this trial for patients with treatment-resistant OCD, can be very effective for those whose OCD does not improve with other treatments. In earlier studies, about 66% of patients experienced significant symptom improvement. Some patients saw their OCD symptoms decrease by 42% to 100%. DBS has also helped with related issues like anxiety and depression, leading to better overall well-being. This makes DBS a promising option for those who have not responded to other treatments.13467
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Implantation
Participants are implanted with permanent DBS SenSight leads and the Medtronic Percept RC IPG
Treatment
Participants undergo DBS activation and participate in clinical assessments and behavioral tasks
Home Monitoring
Participants' neural and behavioral data are collected in a naturalistic setting using passive recordings and wearables
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Deep Brain Stimulation
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Find a Clinic Near You
Who Is Running the Clinical Trial?
Baylor College of Medicine
Lead Sponsor
Citations
Deep brain stimulation for treatment resistant obsessive ...
Out of our 10 patients, 6 have shown a clear response indicated by a YBOCS-reduction between 42 and 100 percent at last follow-up. One further ...
Efficacy of deep brain stimulation for obsessive-compulsive ...
DBS does not only improve OCD, but also associated anxiety, depression and overall function. •. This work supports earlier arguments for a more widespread ...
Efficacy of deep brain stimulation for treatment-resistant ...
Sixty-six per cent of patients in well-designed studies achieved response to DBS therapy, which compares with or outperforms recent estimates of treatment ...
Deep brain stimulation for treatment resistant obsessive ...
Our results suggest that BNST-DBS can be effective for treatment-resistant OCD patients, as indicated by a reduction in symptoms and an overall improvement in ...
Study finds DBS increasingly viable option for treatment- ...
“DBS is a viable option for treatment-resistant OCD that can be expected to produce significant clinical benefit in about two out of three cases ...
A prospective international multi-center study on safety and ...
In conclusion, DBS for severe treatment-resistant OCD patients reduced the severity of obsessive-compulsive symptoms by an average of 40%, with ...
Effectiveness of Deep Brain Stimulation for Treating People ...
This study will evaluate the safety and effectiveness of DBS in treating people with severe and otherwise treatment-resistant OCD. Study participation through ...
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