Popular Trials
Behavioural Intervention
Incontinence Management Tool for Spina Bifida
This trial is testing a new tool to help spina bifida patients and their urologists work together to identify goals for treating urinary and fecal incontinence. The tool will help patients communicate their symptoms and what they hope to achieve, so that the most appropriate treatment can be determined.
Procedure
Surgical Sectioning for Tethered Cord Syndrome
This trial is testing whether a surgery to cut a small piece of tissue at the end of the spinal cord is better than standard medical treatments for patients with Occult Tethered Cord Syndrome (OTCS). These patients often do not find relief from typical treatments. The surgery aims to relieve pressure and tension in the spinal cord, which may help improve their symptoms. This surgical method is currently the most widely accepted treatment for OTCS.
Stem Cell Therapy
Stem Cell Therapy for Spina Bifida
This trial is testing a new treatment for spina bifida, which is a birth defect where the spinal cord is exposed. The treatment involves adding stem cells to the repair, which is effective in animals and is thought to be safe.
Behavioural Intervention
Movement-2-Music Exercise Program for Mobility Disabilities
This trial is testing the effects of an innovative exercise program, movement-2-music (M2M), on health and fitness outcomes in adults with physical/mobility disabilities. One hundred and eight participants will be recruited and randomly enrolled into one of two groups: M2M or waitlist control. The primary aim of this study is to determine the effects of the 12-week M2M program on health and fitness in participants with physical/mobility disabilities. The study will also compare the observed effects of the program to a previous M2M study, and test whether adherence (attendance to the 12-week program) affects the
Procedure
Fetoscopic Repair Techniques for Spina Bifida
This trial will compare two techniques for repairing a birth defect called myelomeningocele. One technique uses a patch and the other does not. The hypothesis is that the technique with the patch will result in a thicker repair and less chance of the repair coming apart.
Popular Filters
Trials for Cerebral Palsy Patients
Robotic Exoskeleton
Robotic Walking Device for Child Movement Disorders
This trial tests a robotic exoskeleton that helps children with walking difficulties due to conditions like cerebral palsy or spinal cord injury. The device can either assist or challenge their walking to strengthen muscles and improve movement. Children will use the exoskeleton in different settings to see if it improves their ability to walk. Robotic exoskeletons have been increasingly used in pediatric rehabilitation to assist children with cerebral palsy in improving their walking abilities.
Behavioural Intervention
Wheelchair Skills Training for Mobility Impairments
This trial tests a training program called Skills on Wheels, which helps children with physical disabilities learn to use manual wheelchairs on their own. The goal is to make them more confident and safe in using their wheelchairs, and to improve their social skills and participation in activities.
Trials for Spinal Cord Injury Patients
Behavioral Intervention
HIFT for Neurological Disorders
This trial aims to assess the effects of exercise on individuals with and without neurologic diagnoses, as well as their care partners. Exercise has long-term physical and psychosocial benefits, so this study looks to see how HIFT helps.
Robotic Exoskeleton
Robotic Walking Device for Child Movement Disorders
This trial tests a robotic exoskeleton that helps children with walking difficulties due to conditions like cerebral palsy or spinal cord injury. The device can either assist or challenge their walking to strengthen muscles and improve movement. Children will use the exoskeleton in different settings to see if it improves their ability to walk. Robotic exoskeletons have been increasingly used in pediatric rehabilitation to assist children with cerebral palsy in improving their walking abilities.
Behavioural Intervention
Wheelchair Skills Training for Mobility Impairments
This trial tests a training program called Skills on Wheels, which helps children with physical disabilities learn to use manual wheelchairs on their own. The goal is to make them more confident and safe in using their wheelchairs, and to improve their social skills and participation in activities.
Trials With No Placebo
Behavioural Intervention
Standing Program for Spina Bifida
"This trial aims to see if a home standing program can help children with spinal bifida who have knee limitations. The study will look at whether this program can reduce limitations in movement, improve functional movement,
Procedure
Fetoscopic Surgery for Spina Bifida
This trial will test two different ways to operate on fetuses with myelomeningocele (a birth defect where the spinal cord doesn't form properly). One approach goes through the mother's skin (percutaneous), and the other goes through the mother's belly (laparotomy/uterine exteriorization).
Frequently Asked Questions
Introduction to spina bifida
What are the top hospitals conducting spina bifida research?
When it comes to advancing research and treatment options for individuals with spina bifida, several hospitals are making significant contributions. In Montreal, the Lethbridge-Layton-Mackay Rehabilitation Center of CIUSSS West-Central Montreal (Mackay site) is leading the way with three active clinical trials focused on this condition. Although relatively new to spina bifida research, having recorded their first trial in 2020, their commitment to expanding knowledge and improving outcomes is evident.
Meanwhile, in Houston, The University of Texas Health Science Center has also taken up the mantle of addressing spina bifida through two ongoing trials. Their dedication resonates as they have been actively pursuing breakthroughs since recording their initial trial in 2020 as well.
In Wellington Regional Medical Center located in Wellington, researchers are currently conducting two active clinical trials for spina bifida. Having initiated their first recorded trial back in 2018 showcases their commitment towards exploring innovative approaches to managing this complex condition.
Furthermore,in Pittsburgh's prestigious University of Pittsburgh where medical excellence thrives,two ongoing investigations are being carried out focusing chiefly on alleviating adverse effects from spina bifida; marking a significant milestone as such experiments were primarily initiated way back during2015 itself.Hence providing solid evidence that these scientific advancements can be long-standing catalysts for better life quality among affected patients
Finally,the National Institutes of Health Clinical Center situated at Bethesda also joins the ranks by contributing immensely through two concurrent studies aimingto improve prognosis among those diagnosed with Spina Bifidawhile taking pride that such undertakings started ground up from year2015back then till date.By constantly seeking ways to further understand and address challenges related to spina bifida,hospitals like these help pave a path towards more effective treatments and improved quality of life for individuals living with this condition
Which are the best cities for spina bifida clinical trials?
When it comes to spina bifida clinical trials, several cities are at the forefront of research and development. Houston, Texas leads with 5 active trials focusing on innovative treatments such as NEOX Cord 1K applied fetoscopically and modified devices in fetoscopic NTD repair. Montreal, Quebec follows closely behind with 3 ongoing studies exploring community-based activity programs and engagement in an 8-week activity program for patients with spina bifida. Additionally, Bethesda, Maryland also has 3 active trials studying interventions like EA-KAFO. These cities offer individuals affected by spina bifida access to cutting-edge clinical trials that contribute to advancements in care for this condition.
Which are the top treatments for spina bifida being explored in clinical trials?
Clinical trials are actively exploring potential treatments for spina bifida, a condition that affects the spinal cord development in babies. Two leading contenders in these trials include NEOX Cord 1K, which is being applied fetoscopically and has two active trials since its first listing in 2020. Another promising approach is fetoscopy, a procedure also being tested in two ongoing clinical trials and was first listed as a treatment option for spina bifida in 2017. These innovative treatments offer hope for improved outcomes and quality of life for individuals living with this condition.
What are the most recent clinical trials for spina bifida?
Exciting advancements in the treatment of spina bifida are emerging through recent clinical trials. Notably, a phase 2 trial has investigated the effectiveness of surgical interventions for individuals with spina bifida. This study aims to evaluate the outcomes and potential benefits of surgery as an intervention option for those affected by this condition. Additionally, another trial has explored fetoscopic surgical repair specifically tailored to address spina bifida cases during pregnancy. By utilizing minimally invasive techniques, this approach shows promise in improving outcomes and potentially reducing complications associated with prenatal interventions. As research continues to progress, these innovative trials bring hope for improved care and management strategies for individuals living with spina bifida.
What spina bifida clinical trials were recently completed?
Recently completed clinical trials focused on spina bifida hold promise for advancements in the treatment of this condition. One such trial, sponsored by the Spina Bifida Association, concluded successfully in June 2021. Another notable trial, backed by the National Institutes of Health, reached completion in March 2021. These significant developments underscore the ongoing efforts of researchers to improve the lives of individuals affected by spina bifida.