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Diuretic

Treatments for Orthostatic Intolerance (Lunar OI Trial)

N/A
Recruiting
Research Sponsored by National Aeronautics and Space Administration (NASA)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Pass a test subject screening facility modified Air Force Class III physical
Be between 18 and 65 years old
Must not have
Currently taking drugs or medications known to adversely interact with furosemide, including but not limited to aspirin, NSAIDs, antibiotics, or immunosuppressant drugs
Type II Diabetes
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 7-8 hours
Awards & highlights
No Placebo-Only Group

Summary

This trial wants to see if there are differences between men and women in how they handle being tilted at different angles to simulate lower gravity levels, like on the Moon. They will also test if wearing a

Who is the study for?
This trial is for healthy men and women to study how they handle changes in body position that simulate the gravity levels astronauts face during lunar missions. Participants must be able to tolerate medication that reduces blood fluid levels, similar to conditions in space.
What is being tested?
The study tests if a compression garment can help with orthostatic intolerance (difficulty adjusting to standing up) by simulating Moon gravity through tilting angles. It also examines differences between males and females using potassium supplements, Furosemide (a diuretic), and the garment.
What are the potential side effects?
Possible side effects include those from taking Furosemide such as dehydration or electrolyte imbalance, discomfort from wearing compression garments, and dizziness or lightheadedness during tilt tests.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I passed a specific physical fitness test.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I am not taking medications that negatively interact with furosemide.
Select...
I have Type II Diabetes.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~7-8 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 7-8 hours for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Blood Pressure
Heart Rate
Plasma Volume
+1 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: Hypovolemic plus garmentExperimental Treatment3 Interventions
Furosemide and potassium supplement plus OIG.
Group II: HypovolemicExperimental Treatment2 Interventions
Furosemide and potassium supplement.
Group III: ControlActive Control1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Compression Garment
2016
N/A
~30

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Who is running the clinical trial?

National Aeronautics and Space Administration (NASA)Lead Sponsor
30 Previous Clinical Trials
1,840 Total Patients Enrolled
~11 spots leftby Sep 2025
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