Interval Training for Parkinson's Disease
Recruiting in Palo Alto (17 mi)
+1 other location
Overseen byJoseph F. Signorile, PhD
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Waitlist Available
Sponsor: University of Miami
No Placebo Group
Trial Summary
What is the purpose of this trial?This research is designed to compare the impact of high-intensity interval training and high-velocity circuit resistance training on heart rate variability, gait, and functional performance in patients with Parkinsons disease.
Do I have to stop taking my current medications for the trial?
The trial protocol does not specify whether you need to stop taking your current medications.
What data supports the idea that Interval Training for Parkinson's Disease is an effective treatment?
The available research shows that high-intensity interval training (HIIT) is a feasible and effective exercise option for people with Parkinson's Disease. It suggests that HIIT can help improve motor symptoms and slow their progression. Compared to other exercise types like resistance training and endurance training, HIIT is considered safe and beneficial. Resistance training improves muscle strength and quality of life, while endurance training enhances fitness and mobility. Overall, these exercise methods, including HIIT, are valuable for managing Parkinson's Disease symptoms.
12345What safety data exists for interval training in Parkinson's disease?
The safety of high-intensity interval training (HIIT) and other intensive exercise modalities for Parkinson's disease (PD) has been evaluated in several studies. A high-intensity exercise boot camp was found to be feasible and safe for individuals with PD. A systematic review and meta-analysis concluded that resistance training (RT), endurance training (ET), and other intensive exercise modalities (OITM) are safe and feasible, without worsening PD symptoms. Additionally, sprint exercise and high-intensity interval cycle ergometer training have been studied for feasibility and safety, with positive findings. Overall, these studies suggest that high-intensity interval training and similar exercises are safe for people with Parkinson's disease.
36789Is High-Intensity Interval Training a promising treatment for Parkinson's Disease?
Yes, High-Intensity Interval Training (HIIT) is a promising treatment for Parkinson's Disease. It can help reduce inflammation, improve learning and memory, and lower the risk of heart disease. HIIT is also effective in managing motor symptoms and enhancing overall quality of life for people with Parkinson's.
12379Eligibility Criteria
This trial is for individuals with Parkinson's Disease, specifically those who have issues with their autonomic nervous system. The exact eligibility criteria are not provided, but typically participants should be medically stable to engage in physical training.Inclusion Criteria
I am between 30 and 90 years old.
My Parkinson's symptoms are mild, as assessed within the last year.
I have been diagnosed with Parkinson's disease.
Exclusion Criteria
Having a pacemaker or other internal medical devices
I have HIV or another immune system condition.
I have a neuromuscular condition that is not Parkinson's disease.
+2 more
Participant Groups
The study compares two exercise approaches: high-intensity interval training (short bursts of intense exercise) and high-velocity circuit resistance training (strength exercises at a fast pace), focusing on their effects on heart rate variability, walking ability, and overall function.
2Treatment groups
Experimental Treatment
Active Control
Group I: High-Intensity Interval TrainingExperimental Treatment1 Intervention
Participants in this group will receive high-intensity interval training 2 times per week for 10 consecutive weeks.
Group II: High-Velocity Circuit Resistance TrainingActive Control1 Intervention
Participants in this group will receive high-velocity circuit resistance training 2 times per week for 10 consecutive weeks.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Laboratory of Neruomuscular Research and Active AgingCoral Gables, FL
University of MiamiCoral Gables, FL
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Who Is Running the Clinical Trial?
University of MiamiLead Sponsor
References
Feasibility and effect of high-intensity training on the progression of motor symptoms in adult individuals with Parkinson's disease: A systematic review and meta-analysis. [2023]To determine the feasibility and effect of high-intensity interval training (HIIT) in individuals with Parkinson's and their effect on symptom modification and progression.
The feasibility, safety, physiological and clinical effects of high-intensity interval training for people with Parkinson's: a systematic review and meta-analysis. [2023]Exercise is important for people with Parkinson's (PwP), with high-intensity interval training (HIIT) proposed as a feasible and effective exercise modality. However, no literature synthesis for PwP has been undertaken.
Parkinson's disease and intensive exercise therapy - An updated systematic review and meta-analysis. [2022]In 2015, Uhrbrand et al. published the first review on Parkinson´s disease (PD) and exercise entirely based on randomized controlled trials (RCT) applying strict exercise definitions. The present review aimed to update the PD literature by assessing the effects of different intensive exercise modalities: resistance training (RT), endurance training (ET), and other intensive exercise modalities (OITM). An updated systematic literature search identified 33 new RCTs. Qualitative and quantitative analyses were performed. A total of 18 RT, 14 ET, and 1 OITM studies were identified (adding to the 8 RT, 6 ET, and 4 OITM studies identified by Uhrbrand et al. in 2015). RT, ET, and OITM were feasible, safe, and did not worsen PD symptoms. Furthermore, RT, ET, and OITM may positively affect functional outcomes (e.g., balance) and depressive symptoms in PD but inconsistencies across these findings warrant cautious conclusions. Meta-analyses showed that RT had a positive impact on muscle strength (standardized mean difference (SMD) = 0.83 [95% CI;0.54, 1.12]), functional capacity (Timed Up and Go Test (TUG): SMD = -0.62 [-1.01, -0.24]), and quality of life (SMD = -0.41 [-0.72, -0.09]), while ET had a positive impact on cardiorespiratory fitness (SMD = 0.27 [0.07, 0.47]) and functional capacity (TUG: SMD = -0.21 [-0.46, 0.04], 6-Min Walk Test: SMD = 0.89 [0.17, 1.62]), and a potentially positive impact on "on-medication" UPDRS-III (SMD = -0.15 [-0.38, 0.09]) and "off-medication" UPDRS-III (SMD = -0.19 [-0.41, 0.04]). In conclusion, RT, ET, and OITM all represent safe, feasible, and beneficial adjunct rehabilitation strategies in PD, with particularly RT and ET showing solid effects.
FIGHT-PD: A feasibility study of periodized boxing training for Parkinson disease. [2023]Boxing training has become a popular form of exercise for people with Parkinson disease (PD). There is a dearth of high-quality feasibility, safety, and efficacy data on boxing training for PD. Feasibility of Instituting Graduated High-intensity Training (FIGHT-PD) aimed to examine these features in a periodized boxing training program featuring high-intensity physical and cognitive demands.
Study in Parkinson's disease of exercise phase 3 (SPARX3): study protocol for a randomized controlled trial. [2023]To date, no medication has slowed the progression of Parkinson's disease (PD). Preclinical, epidemiological, and experimental data on humans all support many benefits of endurance exercise among persons with PD. The key question is whether there is a definitive additional benefit of exercising at high intensity, in terms of slowing disease progression, beyond the well-documented benefit of endurance training on a treadmill for fitness, gait, and functional mobility. This study will determine the efficacy of high-intensity endurance exercise as first-line therapy for persons diagnosed with PD within 3 years, and untreated with symptomatic therapy at baseline.
A High-Intensity Exercise Boot Camp for Persons With Parkinson Disease: A Phase II, Pragmatic, Randomized Clinical Trial of Feasibility, Safety, Signal of Efficacy, and Disease Mechanisms. [2022]The feasibility, safety, and efficacy of a high-intensity multimodal exercise program (aerobic, strengthening, and balance training) have not been well vetted in persons with Parkinson disease (PD). Thus, the primary aim was to determine whether a high-intensity multimodal exercise boot camp (HIBC) was both feasible and safe in persons with PD. The secondary aim was to determine whether the program would produce greater benefit than a usual care, low-intensity exercise program (UC). An exploratory aim was to determine whether these programs affected putative disease-modifying mechanisms.
High-intensity interval training modulates inflammatory response in Parkinson's disease. [2022]Recent discoveries show that high-intensity interval training (HIIT) can bring many positive effects such as decreases in fat tissue, lower blood sugar levels, improved learning and memory, and lower risk of cardiac disease. Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of the dopaminergic neurons, accompanied by chronic inflammation and neuroinflammation. Previous research shows that interval training can bring a beneficial effect on the inflammation and neuroplasticity in PD.
Sprint exercise for subjects with mild-to-moderate Parkinson's disease: Feasibility and biomechanical outputs. [2021]High-intensity training, a still unexplored exercise for individuals with Parkinson's disease, is positively related with increased functionality and aerobic profile in healthy individuals. The aim of this work was to evaluate the feasibility, safety, and acceptance of sprint running in individuals with mild-to-moderate Parkinson's. Additionally, we compared sprint biomechanical outputs of force, velocity and power between individuals with Parkinson's disease and healthy.
High-Intensity Interval Cycle Ergometer Training in Parkinson's Disease: Protocol for Identifying Individual Response Patterns Using a Single-Subject Research Design. [2020]Background: People with Parkinson's disease (PD) experience not only motor problems but also non-motor problems that seriously impede their daily functioning and quality of life. The current pharmacologic treatment of PD is symptomatic, and alternative rehabilitation treatments, which preferably also have a disease-modifying effect and promote neuroplasticity, are needed. Recent studies suggest that high-intensity interval training (HIIT) is promising for promoting neuroplasticity in human PD, with short training time and reduced burden. Biomarkers for neuroplasticity such as brain-derived neurotrophic factor (BDNF) and neurodegeneration (including neurofilament NfL and α-synuclein) may play a role, but their response to HIIT is not well-investigated. Objectives: The aims of this study were (1) to study the effects of 4 weeks of HIIT compared with 4 weeks of continuous aerobic exercise on motor and non-motor outcomes of PD and (2) to investigate the association between HIIT, motor/non-motor performances changes, and blood biomarker levels for neuroplasticity and neurodegeneration. Study Design: Single-subject research design with alternating treatment setup (ABACA) and frequent repeated measurements was used. Each participant received different intervention conditions (B/C) interspersed with baseline periods (A, i.e., ABACA or ACABA), and frequent repeated assessment of outcome measures is done to quantify within-subject, individual response patterns with sufficient power for data analysis. Blood samples were collected once a week in the baseline and training phases (A1 and B/C) and once every 2 weeks in the washout phases (A2 and A3). Intervention: Four subjects with PD on stable dopaminergic medication, two in Hoehn-Yahr stage 1-2, and two in Hoehn-Yahr stage 2.5-3 followed an ABACA or ACABA schedule, consisting of blocks with 30-min sessions of "B" (HIIT) or 50-min sessions of "C" [continuous aerobic exercise (CAE)] 3×/week for 4 weeks, separated by baseline "A" periods of 8 weeks for a total duration of 28 weeks. Outcome Measures: Outcome measures include disease status [Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS)], blood biomarkers (BDNF, Nfl, and α-synuclein), measures for functional mobility (including an activity tracker), and activities of daily living, as well as cognition, mood, biorhythm (sleeping problems), and quality of life. Data Analysis: Visual analysis of trends in level, slope, and variability in response patterns was carried out, confirmed by longitudinal regression analysis with phase (ABACA) as the independent variable.