HyperSight Imaging for Cancer
Recruiting in Palo Alto (17 mi)
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Varian, a Siemens Healthineers Company
Disqualifiers: Pregnancy, Cardiac devices, Genetic sensitivity, others
No Placebo Group
Trial Summary
What is the purpose of this trial?The primary objective of radiation therapy is to deliver a therapeutic dose of radiation precisely to the target while minimizing exposure to healthy surrounding tissues. Image-guided radiation therapy (IGRT) involves acquiring cone beam computed tomography (CBCT) scans just before or during treatment sessions. By comparing the CBCT images with the reference images from the treatment planning process, clinicians can make necessary adjustments to ensure precise targeting and account for any changes that may have occurred since the initial planning. Conventional CBCT technology is, however, limited by several factors including long acquisition times that result in motion artifacts in the image, smaller fields of view that limit the volume of anatomy that can be imaged, poor image quality that limits soft tissue visibility, and artifacts created by dense metal implants. This study will evaluate a novel CBCT imaging solution ("HyperSight") that has the potential to address the challenges of conventional CBCT.
Do I need to stop my current medications for the HyperSight Imaging trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment HyperSight Imaging for cancer?
The research shows that HyperSight Imaging, a type of cone beam computed tomography (CBCT), provides high-quality images quickly, which can be useful in guiding cancer treatments. This technology is also being used in other medical procedures due to its ability to offer detailed images, suggesting it could be effective in cancer treatment as well.
12345Is HyperSight Imaging generally safe for humans?
Research on similar imaging technology, cone beam computed tomography (CBCT), shows that while it is useful, there are concerns about radiation exposure. Studies highlight the importance of understanding and managing radiation doses to ensure patient safety.
678910How is the HyperSight Imaging treatment different from other cancer treatments?
HyperSight Imaging uses a novel cone beam computed tomography (CBCT) platform that provides rapid and high-quality imaging, which can enhance the precision of cancer treatments by allowing better visualization and targeting of tumors compared to traditional imaging methods.
1231112Eligibility Criteria
This trial is for individuals with various cancers (pelvic, head and neck, breast, lung, gastric, gastrointestinal tumors) who require precise radiation therapy. Participants should need image-guided radiation treatment but are not specified by other inclusion or exclusion criteria in the provided information.Inclusion Criteria
Patient is willing and able to provide written consent.
I have a confirmed cancer diagnosis and need radiation therapy in specific areas.
I am able to get out of my bed or chair and move around.
+2 more
Exclusion Criteria
I am getting a short course of radiation therapy for symptom relief.
I have a genetic condition that makes me sensitive to radiation.
Patient is part of a vulnerable population (per ISO 14155:2020, "individuals who are unable to fully understand all aspects of the investigation that are relevant to the decision to participate, or who could be manipulated or unduly influenced as a result of a compromised position, expectation of benefits or fear of retaliatory response"). This includes prisoners.
+2 more
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Imaging Evaluation
Subjects are imaged with the new HyperSight CBCT imaging system to evaluate image quality, noise, and artifact levels compared to conventional CT imaging.
1-9 weeks
Multiple imaging sessions
Follow-up
Participants are monitored for safety and effectiveness of the HyperSight imaging system, including patient experience and breath hold tolerance.
1 year
Participant Groups
The study is testing 'HyperSight Imaging,' a new type of imaging technology designed to improve the accuracy of radiation therapy. It aims to overcome limitations like long scan times and poor image quality seen with conventional cone beam computed tomography (CBCT).
1Treatment groups
Experimental Treatment
Group I: HyperSight Imaging armExperimental Treatment1 Intervention
Subjects are imaged with the new HyperSight CBCT imaging system.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
University of Maryland Medical CenterBaltimore, MD
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Who Is Running the Clinical Trial?
Varian, a Siemens Healthineers CompanyLead Sponsor
References
Novel Technology Allowing Cone Beam Computed Tomography in 6 Seconds: A Patient Study of Comparative Image Quality. [2023]The goal of this study was to evaluate the image quality provided by a novel cone beam computed tomography (CBCT) platform (HyperSight, Varian Medical Systems), a platform with enhanced reconstruction algorithms as well as rapid acquisition times. Image quality was compared with both status quo CBCT for image guidance, and to fan beam CT (FBCT) acquired on a CT simulator (CTsim).
Extended Intraoperative Longitudinal 3-Dimensional Cone Beam Computed Tomography Imaging With a Continuous Multi-Turn Reverse Helical Scan. [2023]Cone beam computed tomography (CBCT) imaging is becoming an indispensable intraoperative tool; however, the current field of view prevents visualization of long anatomical sites, limiting clinical utility. Here, we demonstrate the longitudinal extension of the intraoperative CBCT field of view using a multi-turn reverse helical scan and assess potential clinical utility in interventional procedures.
C-arm Cone Beam Computed Tomography: A New Tool in the Interventional Suite. [2020]C-arm Cone Beam CT (CBCT) is a technology that is being integrated into many of the newer angiography systems in the interventional suite. Due to its ability to provide cross sectional imaging, it has opened a myriad of opportunities for creating new clinical applications. We review the technical aspects, current reported clinical applications and potential benefits of this technology.
Comparison of cone-beam imaging with orthopantomography and computerized tomography for assessment in presurgical implant dentistry. [2022]To establish a basis for weighing the potential diagnostic and therapeutic benefits of three-dimensional cone-beam (CB) data sets in contrast to digital orthopantomography (OPG) and computerized tomography (CT) in implant dentistry.
Dental students' knowledge and attitude towards cone-beam computed tomography: An Indian scenario. [2018]Cone-beam computed tomography (CBCT) is an upcoming imaging modality in field of dentistry with promising outcomes.
Radiation dose in cone beam CT guided ERCP. [2021]To evaluate the practical and radiation safety considerations in utilization of 3-D imaging through cone beam computed tomography (CBCT) in endoscopic retrograde cholangiopancreatography (ERCP).
Radiation exposure of abdominal cone beam computed tomography. [2015]To evaluate patients radiation exposure of abdominal C-arm cone beam computed tomography (CBCT).
Evaluation of the accuracy of cone beam computerized tomography (CBCT): medical imaging technology in head and neck reconstruction. [2022]With the introduction, development and commercialization of Cone Beam Computerized Tomography (CBCT) technologies in the field of head and neck reconstruction, clinicians now have increased access to the technology. Given the growth of this new user group, there is an increasing concern regarding proper use, understanding, quality and patient safety.
CBCT in orthodontics: a systematic review on justification of CBCT in a paediatric population prior to orthodontic treatment. [2020]Taking into account radiation doses, safety, and protection, we highlighted the features in which cone-beam computed tomography (CBCT) can offer an advantage compared to the conventional two-dimensional imaging in paediatric dentistry before orthodontic treatment.
Megavoltage cone beam CT near surface dose measurements: potential implications for breast radiotherapy. [2017]Cone beam computed tomography (CBCT) is fast becoming standard on modern linear accelerators. CBCT increases the dose to regions within and outside the treatment field, potentially increasing secondary cancer induction and toxicity. This study quantified megavoltage (MV) CBCT skin dose and compared it to skin dose delivered during standard tangential breast radiotherapy.
C-arm cone-beam computed tomography in interventional oncology: technical aspects and clinical applications. [2021]C-arm cone-beam computed tomography (CBCT) is a new imaging technology integrated in modern angiographic systems. Due to its ability to obtain cross-sectional imaging and the possibility to use dedicated planning and navigation software, it provides an informed platform for interventional oncology procedures. In this paper, we highlight the technical aspects and clinical applications of CBCT imaging and navigation in the most common loco-regional oncological treatments.
How I do it: Cone-beam CT during transarterial chemoembolization for liver cancer. [2018]Cone-beam computed tomography (CBCT) is an imaging technique that provides computed tomographic (CT) images from a rotational scan acquired with a C-arm equipped with a flat panel detector. Utilizing CBCT images during interventional procedures bridges the gap between the world of diagnostic imaging (typically three-dimensional imaging but performed separately from the procedure) and that of interventional radiology (typically two-dimensional imaging). CBCT is capable of providing more information than standard two-dimensional angiography in localizing and/or visualizing liver tumors ("seeing" the tumor) and targeting tumors though precise microcatheter placement in close proximity to the tumors ("reaching" the tumor). It can also be useful in evaluating treatment success at the time of procedure ("assessing" treatment success). CBCT technology is rapidly evolving along with the development of various contrast material injection protocols and multiphasic CBCT techniques. The purpose of this article is to provide a review of the principles of CBCT imaging, including purpose and clinical evidence of the different techniques, and to introduce a decision-making algorithm as a guide for the routine utilization of CBCT during transarterial chemoembolization of liver cancer.