Low-Fat Diet + Fish Oil for Prostate Cancer

Recruiting in Palo Alto (17 mi)

Overseen byWilliam Aronson

Age: 18+

Sex: Male

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Jonsson Comprehensive Cancer Center

No Placebo Group

Trial Summary

What is the purpose of this trial?

This randomized phase II trial will evaluate if a low omega-6, high omega-3 fat diet combined with fish oil has the potential to delay disease progression in patients with prostate cancer undergoing active surveillance.

Research Team

William Aronson

Principal Investigator

Jonsson Comprehensive Cancer Center

Eligibility Criteria

This trial is for men with prostate cancer who are on active surveillance, have a Gleason grade of 3+4 or less, and a PSA level under 20. They must not consume certain supplements or fish oil capsules during the study and be able to visit UCLA for check-ups. Men who've had prior prostate cancer treatments or take specific medications can't join.

Inclusion Criteria

Patients sign the informed consent

I agree not to take fish oil capsules if placed in the control group.

PSA < 20

See 6 more

Exclusion Criteria

I have taken finasteride or dutasteride in the last year.

I have had treatment for prostate cancer before.

My prostate cancer was found in just one biopsy core and affects less than 5% of that sample.

See 3 more

Treatment Details

Interventions

Behavioral Dietary Intervention (Behavioral)
Omega-3 Fatty Acid (Omega-3 Fatty Acid)

Trial OverviewThe trial is testing if a low-fat diet combined with fish oil supplements can slow down prostate cancer progression in patients opting for active surveillance rather than immediate treatment.

Participant Groups

2Treatment groups

Experimental Treatment

Active Control

Group I: Arm II (fish oil)Experimental Treatment3 Interventions

Patients receive dietary counseling with research dietitian weekly for 1 month and then monthly for 11 months. Patients are given guidelines with recommended meals to follow a low omega-6, high omega-3 fat diet combined with fish oil. Patients also receive 4 fish oil capsules per day PO for 1 year.

Group II: Arm I (control)Active Control1 Intervention

Patients receive no intervention.