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CPAP for Supine Hypertension

N/A
Recruiting
Led By Italo Biaggioni, MD
Research Sponsored by Vanderbilt University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 hours

Summary

This trial will assess whether CPAP can help to lower blood pressure in patients with autonomic failure who also have supine hypertension.

Who is the study for?
This trial is for patients with autonomic failure who also have high blood pressure when lying down. It's open to all races but not for medical students, pregnant women, or those at high risk like heart failure, serious coronary issues, liver problems, or a history of stroke or heart attack. People with severe allergies or asthma can't join.
What is being tested?
The study is testing if using continuous positive airway pressure (CPAP) can lower blood pressure in people who experience higher blood pressure while lying down due to autonomic failure. A CPAP machine helps breathing and might affect blood pressure.
What are the potential side effects?
While the trial doesn't specify side effects, common ones from CPAP include discomfort in the chest muscles, dry nose or throat, skin irritation from the mask, and sometimes feeling claustrophobic.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 hours for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Supine Systolic Blood Pressure
Secondary study objectives
Urinary volume

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: CPAP (continuous positive airway pressure)Active Control1 Intervention
Continuous positive airway pressure during the night
Group II: Placebo pill or patch or sham CPAPPlacebo Group1 Intervention
Placebo pill or patch or sham CPAP

Find a Location

Who is running the clinical trial?

Vanderbilt University Medical CenterLead Sponsor
907 Previous Clinical Trials
934,575 Total Patients Enrolled
Italo Biaggioni, MDPrincipal Investigator - Vanderbilt University Medical Center
Vanderbilt University Medical Center
28 Previous Clinical Trials
1,442 Total Patients Enrolled

Media Library

continuous positive airway pressure (CPAP) (Other) Clinical Trial Eligibility Overview. Trial Name: NCT03312556 — N/A
Dysautonomia Research Study Groups: CPAP (continuous positive airway pressure), Placebo pill or patch or sham CPAP
Dysautonomia Clinical Trial 2023: continuous positive airway pressure (CPAP) Highlights & Side Effects. Trial Name: NCT03312556 — N/A
continuous positive airway pressure (CPAP) (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03312556 — N/A
~2 spots leftby Sep 2026
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