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Opioid-Free vs Opioid-Based Anesthesia for Postoperative Recovery (PERFECT Trial)
Los Angeles, CA
N/A
Waitlist Available
Led By Alexandre JOOSTEN, MD PhD
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age >18 years
Be older than 18 years old
Must not have
Preoperative prescribed opioids
Contraindications to study drug (lidocaine, magnesium, dexmedetomidine, ketamine)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up postoperative day 30
Awards & highlights
No Placebo-Only Group
Summary
This trial aims to compare how patient preference for opioid use during surgery affects their recovery after abdominal surgery. Using alternative pain relief methods instead of opioids is becoming more popular, but patient involvement in decision-making about
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Who is the study for?
This trial is for patients scheduled for moderate risk laparoscopic/robotic abdominal surgery. It's designed to see if people prefer opioid-free anesthesia or traditional opioid-based methods, and how their choice affects recovery after surgery.Check my eligibility
What is being tested?
The study tests two types of anesthesia: one without opioids (OFA) and the other with them. Patients' preferences are considered to understand the impact on postoperative recovery quality following abdominal surgery.See study design
What are the potential side effects?
While specific side effects aren't listed, generally, opioid-based anesthesia can lead to nausea, constipation, drowsiness or respiratory depression. Opioid-free options may have different side effects based on the alternative analgesics used.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am older than 18 years.
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Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
I have been prescribed opioids before surgery.
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I am not allergic or unable to take lidocaine, magnesium, dexmedetomidine, or ketamine.
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I am under judicial protection or have a legal guardian.
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I have been diagnosed with chronic pain.
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Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ postoperative 30
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~postoperative 30
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Quality of recovery (QoR15)
Secondary study objectives
Anesthesia satisfaction
Early quality of recovery on POD#1
Health quality of life
+5 moreAwards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Patient choose his analgesia typeExperimental Treatment2 Interventions
The patient here can decide which type of analgesia he/she wants ( OFA vs OBA)
Group II: Patient does not choose his analgesia strategyActive Control2 Interventions
If the patient does not choose his analgesia strategy, he/she will be randomized to OFA or OBA
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Opioid based Anesthesia
2022
Completed Phase 3
~180
opioid free anesthesia
2019
N/A
~420
Find a Location
Closest Location:UCLA Ronald Reagan medical center· Los Angeles, CA· 1976 miles
Who is running the clinical trial?
University of California, Los AngelesLead Sponsor
1,585 Previous Clinical Trials
10,421,998 Total Patients Enrolled
Alexandre JOOSTEN, MD PhDPrincipal InvestigatorUniversity of California, Los Angeles
2 Previous Clinical Trials
40 Total Patients Enrolled