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The Impact of a Single Dexmedetomidine Bolus on Intraoperative Sevoflurane Consumption (DEXHALE)
N/A
Recruiting
Research Sponsored by Ciusss de L'Est de l'Île de Montréal
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from pacu admission to discharge
Summary
This trial aims to reduce sevoflurane's environmental impact while maintaining its benefits in surgery. An alternative drug, dexmedetomidine, will be tested in a randomized controlled trial.
Eligible Conditions
- Dexmedetomidine
- Sevoflurane
- Laparoscopy
- Inhalation Anesthesia
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ from intubation to end of surgery
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from intubation to end of surgery
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Sevoflurane
Secondary study objectives
Vasoconstrictor Agents
Mean end tidal sevoflurane (in %) and MAC needed to maintain the BIS index (Medtronic, Canada) between 40 and 60
Pain
+7 moreTrial Design
2Treatment groups
Active Control
Placebo Group
Group I: DexmedetomidineActive Control1 Intervention
Dexmedetomidine 0.6 mcg/kg (adjusted body weight) ; Administered via infusion pump (Smith Medical Medfusion® 4000 Syringe Infusion Pump) so that the full dose is delivered over 10 minutes during induction of general anesthesia
Group II: PlaceboPlacebo Group1 Intervention
Normal saline in volume equivalent of dexmedetomidine dose according to patient weight ; Administered via infusion pump (Smith Medical Medfusion® 4000 Syringe Infusion Pump) so that the full dose is delivered over 10 minutes during induction of general anesthesia
Find a Location
Who is running the clinical trial?
Ciusss de L'Est de l'Île de MontréalLead Sponsor
78 Previous Clinical Trials
6,331 Total Patients Enrolled
1 Trials studying Dexmedetomidine
72 Patients Enrolled for Dexmedetomidine