Popular Trials
Procedure
rTMS for Post-Concussion Syndrome
This trial studies how rTMS, a non-invasive brain stimulation technique, can help reduce chronic headaches from mild traumatic brain injury (mTBI). It aims to improve post-concussion symptoms & reduce costs of delayed recovery.
Behavioural Intervention
Osteopathic Manipulative Treatment for Headaches
This trial aims to investigate if osteopathic manipulation or light touch can help reduce the frequency of headaches and the use of pain medication. They will compare the effects of a specific osteopathic treatment with a light
Popular Filters
Trials for Migraine Patients
Behavioral Intervention
Behavioral Treatment for Migraines
This trial aims to understand and improve a behavioral intervention for migraines. It will also investigate the best combinations of treatments and how people's preferences and choices can affect the trial outcomes.
Corticosteroid
CBT + Amitriptyline for Childhood Migraine
This trial will compare Cognitive Behavioral Therapy (CBT) via telehealth with a pill-based preventive therapy (amitriptyline) for treating childhood migraine. Results will help provide evidence-based, accessible care.
Behavioral Intervention
Mind-Body Balance for Pediatric Migraine
This trial is testing a mind-body intervention delivered by a nurse, using different doses of three treatment components, to find the combination that works best to reduce the number of headache days.
Local Anesthetic
Exparel for Craniofacial Pain
This trial tests if injecting Exparel into the nasal area can help people with craniofacial pain. Exparel is a long-lasting pain reliever, and the study focuses on those who usually get pain relief from Lidocaine during ENT procedures.
Trials for MA Patients
Behavioral Intervention
Behavioral Treatment for Migraines
This trial aims to understand and improve a behavioral intervention for migraines. It will also investigate the best combinations of treatments and how people's preferences and choices can affect the trial outcomes.
Corticosteroid
CBT + Amitriptyline for Childhood Migraine
This trial will compare Cognitive Behavioral Therapy (CBT) via telehealth with a pill-based preventive therapy (amitriptyline) for treating childhood migraine. Results will help provide evidence-based, accessible care.
Behavioral Intervention
Mind-Body Balance for Pediatric Migraine
This trial is testing a mind-body intervention delivered by a nurse, using different doses of three treatment components, to find the combination that works best to reduce the number of headache days.
Local Anesthetic
Exparel for Craniofacial Pain
This trial tests if injecting Exparel into the nasal area can help people with craniofacial pain. Exparel is a long-lasting pain reliever, and the study focuses on those who usually get pain relief from Lidocaine during ENT procedures.
Phase 3 Trials
NMDA Receptor Antagonist
Ketamine for Chronic Daily Headache
This trial is a multicenter, placebo-controlled, parallel group randomized trial with blinding of participants and observers with the goal of comprehensively assessing the effect of high-dose IV ketamine infusion (1 mg.kg-1.h-1 for six hours) on the frequency and intensity of headaches, mood, activity, sleep, quality of life and safety of ketamine for three months after the interventions.
Trials With No Placebo
Behavioral Intervention
Behavioral Treatment for Migraines
This trial aims to understand and improve a behavioral intervention for migraines. It will also investigate the best combinations of treatments and how people's preferences and choices can affect the trial outcomes.
Corticosteroid
CBT + Amitriptyline for Childhood Migraine
This trial will compare Cognitive Behavioral Therapy (CBT) via telehealth with a pill-based preventive therapy (amitriptyline) for treating childhood migraine. Results will help provide evidence-based, accessible care.
Behavioral Intervention
Mind-Body Balance for Pediatric Migraine
This trial is testing a mind-body intervention delivered by a nurse, using different doses of three treatment components, to find the combination that works best to reduce the number of headache days.
View More Related Trials
Frequently Asked Questions
Introduction to headache
What are the top hospitals conducting headache research?
When it comes to finding relief for chronic headaches, top hospitals across the United States are leading the way in groundbreaking clinical trials. In Chicago, the Diamond Headache Clinic has emerged as a prominent institution with five ongoing headache trials and a total of 13 completed studies dedicated to this condition. Since beginning their pioneering research in 2002, they have been at the forefront of advancing knowledge and treatment options for patients suffering from debilitating headaches.
Moving eastward to Stamford, Connecticut, the New England Institute for Clinical Research is making significant contributions as well. With four active headache trials and seven all-time studies focused on this condition since their first recorded trial in 2012, they are diligently working towards uncovering new therapeutic strategies that can bring relief to those affected by frequent headaches.
In Cincinnati, Ohio, researchers at Cincinnati Children's Hospital Medical Center are also dedicated to understanding and treating headaches. Despite having three ongoing headache trials and only four all-time studies conducted since their inaugural trial in 2012, their commitment shines through as they strive to improve management techniques specifically tailored for pediatric patients dealing with these often-painful conditions.
Heading further west to Rochester, Minnesota brings us to the prestigious Mayo Clinic—one of the most renowned medical facilities globally. Here too we find dedicated researchers working on alleviating headaches through three currently active clinical trials along with five previous investigations since recording their first headache trial in 2013.
Lastly but no less important is Youngstown State University located in Youngstown which may appear smaller-scale yet plays an essential role within this field. With three ongoing headache trials and valuable contribution gained from conducting previous four investigations starting just a few years ago backin2018; They continuously aspire toward expanding our understanding surrounding various typesofheadachesand strivingto develop effective treatments that help enhance quality lives being affected by them
These leading institutions not only offer hope but also serve as beacons of progress when it comes to finding solutions for individuals living with chronic headaches. Through their unwavering dedication and commitment to innovative research, they are paving the way for improved therapies that can provide relief and transform the lives of countless patients worldwide.
Which are the best cities for headache clinical trials?
When it comes to headache clinical trials, several cities are at the forefront of research. Phoenix, Arizona leads with 12 active trials investigating treatments like Galcanezumab, Eptinezumab, and Erenumab. Following closely behind are Rochester, Minnesota; Seattle, Washington; and Chicago, Illinois with 8 ongoing studies each focusing on various interventions such as vagal nerve stimulation and regional anesthetic techniques. Stamford, Connecticut also plays a significant role in headache research with 7 active trials exploring treatments including Galcanezumab and Eptinezumab. These cities offer individuals experiencing headaches access to cutting-edge clinical trials that may provide new insights into managing this debilitating condition.
Which are the top treatments for headache being explored in clinical trials?
Exploring the realm of headache treatments through clinical trials reveals several promising options. Dexamethasone, a well-established contender, currently features in two active headache trials and has been listed since 2005. Another newcomer making waves is eptinezumab, which has also demonstrated its potential with two ongoing trials since its introduction in 2020. Galcanezumab joins this elite group as well, participating in two active headache trials and first entering the scene back in 2014. These advancements bring renewed hope for alleviating the burden of headaches and improving the quality of life for patients worldwide.
What are the most recent clinical trials for headache?
Exciting developments are underway in the field of headache research, with recent clinical trials shedding light on potential breakthroughs. One such trial is exploring the efficacy of ReMMiD-C Therapeutic Arm A, a phase 3 study aimed at providing relief for individuals suffering from headaches. Additionally, a phase 1 trial is investigating the benefits of Cannabidiol-enriched Cannabis Herbal Extract as a possible treatment option. These studies mark significant advancements in understanding and addressing headaches, offering hope to those affected by this debilitating condition.
What headache clinical trials were recently completed?
Recently, several clinical trials investigating potential treatments for headaches have concluded, offering promising insights into managing this debilitating condition. In September 2021, H. Lundbeck A/S completed a trial evaluating the efficacy of Eptinezumab. Similarly, the University of Alabama at Birmingham wrapped up their research on Occipital Nerve Block in February 2020. Furthermore, Weill Medical College of Cornell University conducted a trial on Botulinum toxin type A that was finalized in August 2018. Although slightly dated now, it is worth noting that Yale University explored Low Dose Psilocybin as a therapeutic option and completed their study back in November 2017. These recent advancements provide important groundwork for further investigations aimed at alleviating the burden of headaches and improving patients' quality of life.