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Spontaneous breathing trial for Acute Respiratory Distress Syndrome

N/A
Waitlist Available
Led By Barbara Schmidt, MD, MSc
Research Sponsored by University of Pennsylvania
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 36 weeks postmenstrual age
Awards & highlights
No Placebo-Only Group

Summary

The objective of this study is to determine whether use of the spontaneous breathing trial allows for earlier successful extubation of very low birth weight (VLBW) infants who are intubated for \>48 hours and have not yet been successfully extubated (extubated \>7 days).

Eligible Conditions
  • Acute Respiratory Distress Syndrome
  • Respiratory Distress Syndrome

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~36 weeks postmenstrual age
This trial's timeline: 3 weeks for screening, Varies for treatment, and 36 weeks postmenstrual age for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
time to successful extubation
Secondary study objectives
bronchopulmonary dysplasia
extubation failure rate

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Spontaneous breathing trialExperimental Treatment1 Intervention
The spontaneous breathing trial will determine the extubation readiness of the subject.
Group II: Usual careActive Control1 Intervention
Subjects will be extubated using usual care, without the use of the spontaneous breathing trial.

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Who is running the clinical trial?

University of PennsylvaniaLead Sponsor
2,081 Previous Clinical Trials
42,724,739 Total Patients Enrolled
Barbara Schmidt, MD, MScPrincipal InvestigatorUniversity of Pennsylvania
4 Previous Clinical Trials
8,118 Total Patients Enrolled
Ann-Johanna Giaccone, MDStudy DirectorUniversity of Pennsylvania
~6 spots leftby Nov 2025
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