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Behavioural Intervention

TMS for Reward Learning

N/A
Recruiting
Research Sponsored by Rutgers, The State University of New Jersey
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up [time frame: day 0 (day of testing)]
Awards & highlights
No Placebo-Only Group

Summary

This trial aims to study how a type of brain stimulation called TMS affects how our brain responds to rewards when we are making decisions. Researchers will use a brain signal called frontal midline theta to see

Who is the study for?
This trial is for individuals struggling with addiction. Participants should be able to perform decision-making tasks and have no conditions that would interfere with TMS treatment or the measurement of brain activity.
What is being tested?
The study tests if Active single pulse Transcranial Magnetic Stimulation (TMS) to the frontal cortex can influence reward processing in the brain during goal-directed behavior, potentially affecting choices and task performance.
What are the potential side effects?
While not specified here, common side effects of TMS may include headache, scalp discomfort at the site of stimulation, tingling or spasms in facial muscles, lightheadedness, and rare risk of seizure.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~[time frame: day 0 (day of testing)]
This trial's timeline: 3 weeks for screening, Varies for treatment, and [time frame: day 0 (day of testing)] for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Event-related Brain Oscillation: Frontal Midline Theta
Reward learning

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Single-pulse Trough Phase TMSExperimental Treatment1 Intervention
Participants will receive a single active TMS pulse during the trough phase target of each task trial and delivered at 110% of participants' resting motor threshold over the predefined frontal target . For the second TMS session, participants will receive single pulse Sham TMS during the peak phase target of each task trial and delivered at 110% of participants' resting motor threshold over the predefined frontal target. Total number of TMS pulse for each session is 520 pulses
Group II: Single-pulse Peak Phase TMSExperimental Treatment1 Intervention
Participants will receive a single active TMS pulse during the peak phase target of each task trial and delivered at 110% of participants' resting motor threshold over the predefined frontal target . For the second TMS session, participants will receive single pulse Sham TMS during the peak phase target of each task trial and delivered at 110% of participants' resting motor threshold over the predefined frontal target. Total number of TMS pulse for each session is 520 pulses

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Who is running the clinical trial?

Rutgers, The State University of New JerseyLead Sponsor
449 Previous Clinical Trials
65,777 Total Patients Enrolled
~10 spots leftby Apr 2025
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