Magnetic Stimulation for Schizophrenia

N/A

Recruiting

Led By Xiaoming Du, PhD

Research Sponsored by The University of Texas Health Science Center, Houston

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 2 weeks

Awards & highlights

No Placebo-Only Group

Summary

This trial will test if using a type of magnetic stimulation can help improve the brain's white matter in patients with schizophrenia spectrum disorder.

Who is the study for?

This trial is for men and women aged 18-60 with schizophrenia-spectrum disorder who can consent to participate. It's not for lab employees, those unable to avoid alcohol/marijuana before experiments, people with significant head injuries or brain conditions, severe drug users, individuals with a history of seizures or thrombosis risks, those on high doses of clozapine (>400 mg/day), or pregnant women.

What is being tested?

The study tests if active repetitive transcranial magnetic stimulation (rTMS) using an H-coil can improve white matter integrity in patients with schizophrenia spectrum disorder. The goal is to enhance brain connectivity through neuromodulation.

What are the potential side effects?

Potential side effects may include discomfort at the stimulation site, headache, lightheadedness, twitching of facial muscles during treatment sessions and in rare cases could potentially trigger seizures.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 2 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~2 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Resting-state functional connectivity (rsFC) from functional MRI

brain microstructural integrity from magnetic resonance imaging (MRI)

Secondary study objectives

Cognitive functions measured by the MATRICS consensus cognitive battery (MCCB)

Cognitive insight, depression, perception, and delusion measured from questionnaires

Electrophysiological responses measured by mismatch negativity and steady-state auditory evoked potentials from electroencephalography recording (EEG)