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Enhanced Emergency Care for Sickle Cell Crisis (SCIENCE Trial)

N/A

Recruiting

Led By David Brousseau, MD, MS

Research Sponsored by Medical College of Wisconsin

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Diagnosis of sickle cell disease

Receipt of at least one opioid

Must not have

Priapism

Sickle cell trait

Timeline

Screening 3 weeks

Treatment Varies

Follow Up a maximum of about 6 hours as all opioids received during the ed stay will be captured

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing a care pathway to see if it increases guideline adherent care for children in the emergency department who have sickle cell disease and are in acute pain.

Who is the study for?

This trial is for children with Sickle Cell Disease (SCD) who visit the emergency department due to a pain crisis and have received at least one opioid. It's not for those with fever over 38.5°C, priapism, sickle cell trait, or acute chest syndrome during their ED visit.

What is being tested?

The study tests a care pathway designed to ensure that children with SCD receive timely and guideline-adherent pain management in the emergency department. The goal is to reduce hospitalizations and improve quality of life by adhering to established pain management guidelines.

What are the potential side effects?

Since this trial focuses on implementing a care pathway rather than testing new medications, there are no direct side effects from interventions being studied. However, general risks associated with opioid use may still apply.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have been diagnosed with sickle cell disease.

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I have taken opioids at least once.

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I visited the ER for a pain crisis that didn't have complications.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have experienced prolonged erections.

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I have sickle cell trait.

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I have had acute chest syndrome.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ a maximum of about 6 hours as all opioids received during the ed stay will be captured

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~a maximum of about 6 hours as all opioids received during the ed stay will be captured

This trial's timeline: 3 weeks for screening, Varies for treatment, and a maximum of about 6 hours as all opioids received during the ed stay will be captured for reporting.