Predictive Assays for Cervical Cancer

Recruiting in Palo Alto (17 mi)

Overseen byAnthony Fyles, MD

Age: 18+

Sex: Female

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University Health Network, Toronto

No Placebo Group

Trial Summary

What is the purpose of this trial?The experiments outlined in this proposal will compare a number of currently available techniques for assessing hypoxia and interstitial fluid pressures in patients with cervix cancer. The aim of these experiments is to establish the relationship of the clinically relevant outcome measures of tumour control and survival following radiation therapy with these biological characteristics of carcinoma of the cervix relevant to tumour hypoxia. These characteristics will be assessed in patients undergoing treatment using techniques which have reached an appropriate level of development for clinical evaluation and aim to determine the best technique for determining these parameters of the tumour microenvironment. A number of novel strategies directed at the microenvironment are undergoing or soon will be undergoing clinical evaluation and selection of appropriate patients for these trials is of great importance.

Eligibility Criteria

This trial is for individuals with a confirmed diagnosis of cervical cancer, who are set to undergo radiation therapy as per the PMH Gynecology Group's treatment guidelines. It's open to those with clinical stage IB-IV and visible cervical disease but no distant metastases. Participants must not have received prior cytotoxic anti-cancer therapy for their condition and must provide signed informed consent.

Inclusion Criteria

My treatment plan includes radiation therapy as decided by my medical team.

I have not received chemotherapy for cervical cancer before joining this study.

I have been diagnosed with cervical cancer.

+3 more

Exclusion Criteria

Not applicable.

Participant Groups

The study is examining various techniques to measure hypoxia (low oxygen levels) and fluid pressures in cervix tumors, aiming to link these factors with tumor control and survival rates post-radiation therapy. The goal is to identify the best method for assessing these aspects of the tumor environment, which could help select patients for future trials targeting the microenvironment.

1Treatment groups

Experimental Treatment

Group I: Assays on cervical cancer tissueExperimental Treatment1 Intervention