Reduced Physical Activity for Sedentary Lifestyle

Recruiting in Palo Alto (17 mi)

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Miami University

No Placebo Group

Trial Summary

What is the purpose of this trial?The far-reaching negative health effects of the reduced physical activity (RPA) epidemic are often overlooked by the general population and health professionals. Short-term RPA induces cardiometabolic dysfunction, including impaired glucose control and vascular function, that may precede disease development. The impact of existing health status on RPA-induced cardiometabolic dysfunction and recovery of impaired glucose control following RPA is unexplored. Thus, the investigators' objectives are 1) to investigate the effect of existing health status (cardiorespiratory fitness and adiposity) on the recovery of impaired glucose control following a period of RPA and 2) to determine the role of vascular function as a mechanism of impaired glucose control. The investigators' final objective is to 3) expose undergraduate students to meritorious biomedical clinical research methods. The investigators have piloted the clinical research methods and analysis with undergraduate researcher associates and are well-prepared to complete this proposal. Preliminary data show that low cardiorespiratory fitness and/or high adiposity impair the recovery of glucose control following short-term RPA. Thus, the investigators aim to examine the interactive role of health status (cardiorespiratory fitness and adiposity) on the ability to recover impaired glucose control following short-term RPA. The investigators also seek to examine changes in vascular function as a mechanism of recovery of impaired glucose control following a return to normal PA. The investigators will recruit men and women with divergent health status (cardiorespiratory fitness and adiposity) to examine glucose control and vascular function during 7-d of normal PA, 7-d of RPA, and 7-d of resumption of normal RA. Continuous glucose monitoring and oral glucose tolerance tests will be performed to assess glucose control. Increases in vascular shear stress induced by passive leg movement and central arterial stiffness will be measured to assess vascular function.

Eligibility Criteria

This trial is for men and women with varying levels of fitness and body fat. It's designed to see how these factors affect blood sugar control after a period of reduced physical activity (like sitting too much). Participants should be generally healthy but may have different exercise habits or weights.

Inclusion Criteria

Active (>7000 steps per day, walking > 1 mile a day outside)

Stable body weight for at least 1 year

Aerobic fitness level, CRF is < 9 and >14 METS

+3 more

Exclusion Criteria

Any injury preventing them from exercising regularly at the time of the screening

My cancer is currently active.

Implantable defibrillator or pacemaker

+5 more

Participant Groups

The study looks at how a week of normal activity, followed by a week of less movement, and then another week back to normal affects blood sugar and blood vessel health. Researchers will use continuous glucose monitoring and tests that measure the body's response to sugar intake.

1Treatment groups

Experimental Treatment

Group I: Reduced physical activityExperimental Treatment1 Intervention

We will recruit, screen, and enroll eligible participants (18-40y) across the following four groups: high CRF/low adiposity, high CRF/high adiposity; low CRF/low adiposity; low CRF/high adiposity. Each participant will undergo a three-week study. For the first week, participants will be instructed to maintain their normal level of physical activity. For the second week, participants' schedules will be examined, and strategies designed to reduce steps (by at least 2000 steps) and physical activity. To assist in reducing walking and increased sitting, participants will be given seated electric scooters to use whenever they normally walk. The scooters will be returned on the third week, and participants will be instructed to resume their normal physical activity. During the entire three weeks, participants will wear a continuous glucose monitor and a physical activity monitor.