Exparel vs. Bupivacaine for Postoperative Pain After Hernia Surgery

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase < 1

Recruiting

Sponsor: Leslie Son

No Placebo Group

Trial Summary

What is the purpose of this trial?While studies have shown improved postoperative pain control with TAP blocks after inguinal and ventral hernia repair, data comparing Liposomal bupivacaine (Exparel) to bupivacaine alone in formulation of the TAP block is particularly scarce. Therefore, we designed a prospective, randomized trial comparing the postoperative pain control in minimally invasive ventral and inguinal hernia repair patients who receive an Exaparel-based TAP block compared to the traditional bupivacaine (Marcaine) TAP block.

Eligibility Criteria

This trial is for adults over 18 with ventral or inguinal hernias needing surgery. It's not for those under 18, chronic pain patients, individuals with very large (>10 cm) or small (<4 cm) defects, allergies to bupivacaine, recurrent hernia history, emergency surgeries, other concurrent surgeries, heavy alcohol users, if the procedure turns open surgery, people weighing less than 50kg or with a BMI over 45.

Inclusion Criteria

I am 18 years old or older.

I need surgery for a hernia in my abdomen or groin area.

Exclusion Criteria

My bupivacaine is mixed with other anesthetics.

I have had a TAP block, but not right before my procedure.

You have a defect that is smaller than 4 centimeters.

+12 more

Participant Groups

The study tests two types of TAP blocks in minimally invasive hernia repairs: one using Exparel (Liposomal Bupivacaine), and the other using Marcaine (Bupivacaine). Patients are randomly assigned to receive either treatment to compare postoperative pain control effectiveness.

2Treatment groups

Active Control

Group I: Liposomal Bupivacaine (Exparel)Active Control1 Intervention

The bilateral TAP block will be performed by the department of anesthesia under ultrasound guidance using 20cc of local anesthetic per side. Additional local anesthetic will be supplied by the surgeon at the incision sites.

Group II: Bupivacaine (Marcaine)Active Control1 Intervention