Adrucil

Breast Cancer, Carcinoma, Basal Cell, Rectal Cancer + 6 more
Treatment
1 FDA approval
20 Active Studies for Adrucil

What is Adrucil

FluorouracilThe Generic name of this drug
Treatment SummaryFluorouracil (5-FU) is an anti-cancer medication that works by blocking the ability of cells to make DNA. It does this by preventing the conversion of a substance called deoxyuridylic acid to thymidylic acid.
Efudexis the brand name
image of different drug pills on a surface
Adrucil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Efudex
Fluorouracil
1970
62

Approved as Treatment by the FDA

Fluorouracil, also known as Efudex, is approved by the FDA for 1 uses like Actinic keratosis .
Actinic keratosis
Used to treat hyperkeratotic actinic keratosis in combination with Salicylic acid

Effectiveness

How Adrucil Affects PatientsFluorouracil is an antineoplastic drug that works by blocking the formation of DNA. It does this by stopping the building blocks of DNA (purines and pyrimidines) from being properly incorporated into the DNA strands. Fluorouracil also blocks an enzyme that converts one type of nucleotide (cytosine) into a different type, and prevents another type of nucleotide (thymidine) from being added to the DNA.
How Adrucil works in the bodyFluorouracil works by stopping cancer cells from replicating. It binds to a protein called thymidylate synthase, which prevents the formation of thymidylate from uracil. This blocks DNA and RNA synthesis, which halts cell growth. Fluorouracil can also be incorporated into RNA instead of the usual uridine triphosphate, interfering with RNA processing and protein synthesis.

When to interrupt dosage

The prescribed dosage of Adrucil is contingent upon the diagnosed condition, like Actinic Keratosis, Verruca (Warts) and non-immunocompromised. The volume of drug is contingent on the technique of delivery (e.g. Solution - Topical or Injection, solution) described in the table beneath.
Condition
Dosage
Administration
Breast Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Actinic Keratosis
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Actinic keratosis
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Warts
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Rectal Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Stomach Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Carcinoma, Basal Cell
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Colon Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Pancreatic Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous

Warnings

Adrucil has a single contraindication and should not be utilized in combination with the conditions shown in the following table.Adrucil Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Adrucil.
Common Adrucil Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with Abetimus.
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Fluorouracil.
Acteoside
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with Acteoside.
Adrucil Toxicity & Overdose RiskTests in mice have found that the lowest toxic dose of the drug is 230mg/kg when taken orally.

Adrucil Novel Uses: Which Conditions Have a Clinical Trial Featuring Adrucil?

1138 active clinical trials are currently assessing the potential of Adrucil to reduce the symptoms of Stomach Cancer, Colon Cancer and Rectal Cancer.
Condition
Clinical Trials
Trial Phases
Rectal Cancer
46 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2
Breast Cancer
30 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 3
Colon Cancer
64 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 3
Stomach Cancer
125 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable
Actinic keratosis
0 Actively Recruiting
Carcinoma, Basal Cell
0 Actively Recruiting
Actinic Keratosis
13 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4
Warts
5 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Pancreatic Cancer
214 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1

Adrucil Reviews: What are patients saying about Adrucil?

2.3Patient Review
10/28/2017
Adrucil for Cancer of Large Intestine
The pump was not easy to deal with for the 49 hours it was in use.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about adrucil

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How is Adrucil given?

"Adrucil is given as an intravenous infusion. A healthcare provider will give you this injection. You may receive your first dose in a hospital or clinic setting to quickly treat any serious side effects."

Answered by AI

What type of drug is Adrucil?

"Adrucil is a prescription medicine used to treat the symptoms of Cancer of the Colon and Rectum, Breast, Gastric, and Pancreatic. Adrucil may be used alone or with other medications. Adrucil belongs to a class of drugs called Antineoplastics and Antimetabolites. It is not known if Adrucil is safe and effective in children."

Answered by AI

Is Adrucil a chemo drug?

"Fluorouracil, sold under the brand name Adrucil among others, is a medication used to treat cancer. Specifically, it is used for the treatment of breast cancer, colorectal cancer, pancreatic cancer, and stomach cancer."

Answered by AI

What is Adrucil used for?

"This medication is used to treat various types of cancer. These cancers include colon cancer, rectal cancer, breast cancer, stomach cancer, and pancreatic cancer. Your doctor may also prescribe this medication to treat other types of cancer."

Answered by AI

Clinical Trials for Adrucil

Have you considered Adrucil clinical trials? We made a collection of clinical trials featuring Adrucil, we think they might fit your search criteria.
Have you considered Adrucil clinical trials? We made a collection of clinical trials featuring Adrucil, we think they might fit your search criteria.
Have you considered Adrucil clinical trials? We made a collection of clinical trials featuring Adrucil, we think they might fit your search criteria.
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