Popular Trials
Menadione Lotion for Cancer-Related Skin Discomfort
This trial studies a menadione lotion to help cancer patients with skin discomfort and distress from their treatments. The lotion is applied to the skin to soothe and protect it, aiming to reduce rashes and pain. Menadione, also known as vitamin K3, has been studied for its potential to activate certain skin receptors and reduce skin rashes caused by cancer treatments.
Regional Anesthesia for Broken Arm
This trial is testing if a numbing injection near the collarbone can better control pain in children aged 4-12 who have specific elbow fractures and need surgery. The injection blocks pain signals from the arm to the brain. The goal is to see if this method reduces the need for pain medicine after surgery.
Monoclonal Antibodies
Denosumab for Fibrous Dysplasia
This trial is testing denosumab, a drug that helps strengthen bones, in adults with fibrous dysplasia, a condition where bones grow abnormally. Denosumab works by stopping the cells that break down bone tissue, aiming to reduce bone pain and improve bone strength.
Procedure
Sociocultural Influences on Pain Assessment
This trial is exploring if social and cultural factors play a role in how people experience pain and how others interpret it. Eligible participants will be asked to complete a series of tests that may include electric shock, thermal stimulation, and viewing images of others in pain.
Popular Filters
Trials for Pain Patients
Procedure
Nerve Block Timing for Shoulder Pain
This trial is testing a procedure where pain medication is injected near neck nerves to manage pain after shoulder surgery. It targets healthy adolescents having shoulder reconstruction. The treatment works by numbing the nerves to block pain signals, helping reduce the need for other painkillers and speeding up recovery. This method has been found to be the most effective way to control pain after shoulder surgery.
Trials for Anxiety Patients
Behavioral Intervention
Acceptance and Commitment Therapy for Postoperative Pain After Knee Replacement
This trial is testing whether Acceptance and Commitment Therapy (ACT) is more effective than Attention Control (AC) in reducing postoperative pain and improving functioning in at-risk Veterans undergoing total knee arthroplasty (TKA).
Cannabinoid
Cannabis for Cancer-Related Symptoms
This trial will test the effectiveness of three cannabis oil extract combinations (High THC-Low CBD, Low THC-High CBD, or Equal amounts of THC and CBD) in a minimum of 120 cancer patients on 4 cancer-related symptoms: nausea, pain, anxiety and sleep disturbance.
VR Therapy for Pain and Anxiety During Medical Procedures
This trial tests if VR can reduce pain and anxiety in children aged 7-21 during medical procedures by distracting them with a virtual world. The study compares the effectiveness of using VR versus not using VR. Virtual reality (VR) has been shown to decrease pain and anxiety in children undergoing various medical procedures.
Virtual Reality for Pain Management During Anesthesia
This trial tests if using VR headsets showing calming scenes can help reduce pain and anxiety in patients aged 18-64 at Cedars-Sinai Medical Center during regional anesthesia. By distracting patients, VR may make them feel less pain and stress. Advancements in virtual reality (VR) technology have resulted in its expansion into health care.
Phase 3 Trials
Behavioral Intervention
Acceptance and Commitment Therapy for Postoperative Pain After Knee Replacement
This trial is testing whether Acceptance and Commitment Therapy (ACT) is more effective than Attention Control (AC) in reducing postoperative pain and improving functioning in at-risk Veterans undergoing total knee arthroplasty (TKA).
Opioid Analgesic
Pain Medication for Postoperative Pain
This trial is testing whether adding Toradol, an anti-inflammatory drug, to the usual opioid painkillers can better manage pain after surgery in patients who have had a specific type of bone surgery. These patients are chosen because they don't need the body's natural inflammation process for healing. Toradol works by reducing inflammation, while opioids change how the brain perceives pain. Toradol, also known as ketorolac, is a nonsteroidal anti-inflammatory drug (NSAID) that has been studied for its opioid-sparing effects in postoperative pain management.
Corticosteroid
PRP vs Corticosteroid Injections for Shoulder Osteoarthritis
This trial investigates LP-PRP injections for young active duty and civilian patients with shoulder osteoarthritis. The treatment uses concentrated platelets from the patient's own blood to promote healing and reduce inflammation, aiming to improve pain and function without surgery. This method has shown potential in treating various inflammatory and degenerative conditions by modulating the inflammatory environment and promoting tissue repair.
Trials With No Placebo
Procedure
Nerve Block Timing for Shoulder Pain
This trial is testing a procedure where pain medication is injected near neck nerves to manage pain after shoulder surgery. It targets healthy adolescents having shoulder reconstruction. The treatment works by numbing the nerves to block pain signals, helping reduce the need for other painkillers and speeding up recovery. This method has been found to be the most effective way to control pain after shoulder surgery.
View More Related Trials
Frequently Asked Questions
Introduction to pain management
What are the top hospitals conducting pain management research?
When it comes to advancing pain management techniques, several top hospitals across the United States are leading the way. In Brooklyn, Maimonides Medical Center has emerged as a pioneer in this field with three active pain management trials and a total of 18 completed studies. The hospital first delved into pain management research in 2013, aiming to provide innovative solutions for those suffering from chronic or acute discomfort. Meanwhile, the prestigious Mayo Clinic in Rochester is also making significant strides with its three ongoing trials and an impressive history of 19 past investigations conducted since their inaugural pain management trial in 2005.
Heading down south to Nashville, Vanderbilt University Medical Center demonstrates its commitment to improving pain management practices through two currently active clinical trials and seven previously conducted studies dating back to their initial exploration of this field in 2003. Boston's Brigham and Women's Hospital joins this cohort of esteemed institutions by offering two ongoing pain management trials alongside a noteworthy record of 16 prior investigations since initiating their pioneering trial back in 2001.
Lastly but not least, located at the heart of Gainesville lies the University of Florida - renowned for its contributions toward innovative approaches to managing various kinds of physical distress. Their dedication shines through with two current pain management trials complemented by twelve accomplished ones stretching all the way back from when they initiated their first-ever study on managing painful conditions sixteen years ago during2021
These leading hospitals' efforts demonstrate that there is hope for individuals living with both short-term and long-term debilitating discomforts like never before. By pushing boundaries through rigorous scientific investigation and collaborative patient care, these institutions bring us closer than ever towards finding effective strategies that can alleviate suffering while enhancing overall quality-of-life standards.
Which are the best cities for pain management clinical trials?
When it comes to pain management clinical trials, several cities have emerged as key hubs for innovative research. New york, New York leads the pack with 9 active trials exploring treatments like Pain Evaluation and BPISF, Non-stiff Intravenous Hydrocortisone, and Sana Pain Reliever. Indianapolis, Indiana closely follows with 8 ongoing studies focused on various treatment approaches. Toronto, Ontario also demonstrates its commitment to advancing pain management with 7 active trials investigating treatments including Group 3 and Cryoneurolysis Group. These cities represent important centers for cutting-edge research in the field of pain management clinical trials.
Which are the top treatments for pain management being explored in clinical trials?
[Pain management](https://www.withpower.com/clinical-trials/pain-management) research is at the forefront of medical exploration, with several promising treatments currently being investigated in clinical trials. Leading the pack is the acetaminophen/naproxen sodium fixed combination, undergoing two active trials since its initial listing in 2023. Following closely behind is intranasal fentanyl (2 mcg/kg), which has shown great potential with one ongoing trial and debuted in 2022. Also making waves is a simple yet effective solution: 10 mL 2% lidocaine, garnering attention with one active trial and first listed in 2021. With each study conducted, we move closer to breakthroughs that could transform pain management for patients worldwide.
What are the most recent clinical trials for pain management?
Exciting advancements are underway in the realm of pain management, as recent clinical trials offer new possibilities for relief. One such trial focuses on the effectiveness of EMLA cream, which has entered Phase 4 and aims to alleviate pain effectively. Additionally, a study specifically targets the population experiencing chronic pain to evaluate alternative management strategies. Another notable trial investigates the potential benefits of an acetaminophen/naproxen sodium fixed combination in mitigating discomfort. Furthermore, researchers explore oral immediate-release oxycodone 10mg as a viable option for managing pain symptoms. Additionally, there is ongoing research into ABC block with bupivacaine and liposomal bupivacaine to enhance current methods of pain management. These recent clinical trials hold promise for improved care and enhanced well-being among individuals suffering from various types of acute or chronic pain conditions.
What pain management clinical trials were recently completed?
Recent clinical trials have made significant strides in the field of pain management, offering hope for improved treatments. In October 2021, the University of Wisconsin, Madison completed a trial investigating Liposomal bupivacaine's potential to alleviate pain. Meanwhile, in September 2021, NorthShore University HealthSystem concluded their study on low-dose naltrexone as a means of managing pain. Additionally, January 2021 saw the completion of a mindfulness trial conducted by the University of California, San Diego. These advancements represent diligent efforts by researchers to address and alleviate chronic pain conditions using innovative approaches.