Aldactone

Nephrotic Syndrome, Ascites, Hypokalemia + 14 more

Treatment

18 FDA approvals

20 Active Studies for Aldactone

Treatment for

Nephrotic Syndrome

What is Aldactone

SpironolactoneThe Generic name of this drug

Treatment SummarySpironolactone is a medication used to treat high blood pressure, heart failure, and other conditions caused by too much aldosterone in the body. It works by preventing the body from reabsorbing too much sodium and water, while allowing the body to retain potassium. It was first developed in 1957 and approved by the FDA in 1960. Off-label uses of spironolactone include treating hirsutism, female pattern hair loss, adult acne, and aiding in medical gender transition.

Spironolactoneis the brand name

image of different drug pills on a surface

Aldactone Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Spironolactone

1960

288

Approved as Treatment by the FDA

Spironolactone, also known as Spironolactone, is approved by the FDA for 18 uses such as Swollen feet or ankles and Ascites .

Swollen feet or ankles

Helps manage Edema

Ascites

Helps manage Ascites

Hypokalemia

chronic heart failure with reduced ejection fraction (NYHA Class IV)

Helps manage chronic heart failure with reduced ejection fraction (NYHA Class IV)

Cirrhosis of the Liver

Helps manage Cirrhosis of the Liver

Primary Hyperaldosteronism

Helps manage Primary Hyperaldosteronism

idiopathic hyperaldosteronism

Helps manage idiopathic hyperaldosteronism

Congestive Heart Failure (CHF)

Helps manage Congestive Heart Failure (CHF)

Hypesthesia

Helps manage chronic heart failure with reduced ejection fraction (NYHA Class IV)

Edema

Helps manage Edema

Hypesthesia

Helps manage chronic heart failure with reduced ejection fraction (NYHA Class III)

Cirrhosis

Helps manage Cirrhosis of the Liver

Hyperaldosteronism

Helps manage Primary Hyperaldosteronism

Nephrotic Syndrome

Helps manage Nephrotic Syndrome

Congestive Heart Failure

Helps manage Congestive Heart Failure (CHF)

Hypertensive disease

Helps manage High Blood Pressure (Hypertension)

Ascites

Helps manage Ascites

Hyperaldosteronism

Helps manage idiopathic hyperaldosteronism

Effectiveness

How Aldactone Affects PatientsSpironolactone was originally studied for the way it helps the body get rid of water without losing too much potassium. It does this by blocking certain receptors in the kidneys that help regulate sodium, water, and potassium levels. It is similar in structure to a hormone called progesterone, and as a result has some of the same effects, such as increased progesterone levels and anti-androgenic effects.

How Aldactone works in the bodySpironolactone works by blocking sodium and potassium channels in the kidneys. This causes more sodium and water to be released from the body, which is how the drug produces its diuretic and anti-hypertension effects. Potassium is the only ion that is not affected, and instead is retained in the body.

When to interrupt dosage

The endorsed dosage of Aldactone is contingent upon the diagnosed condition, such as Hypesthesia, Congestive Heart Failure and Cirrhosis. The measure of dosage fluctuates, depending on the method of administration specified in the accompanying table.

Condition

Dosage

Administration

Nephrotic Syndrome

50.0 mg, , 100.0 mg, 25.0 mg, 25.0 mg/mL, 0.02 mg/mg, 0.05 mg/mg