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What is Erlotinib Hydrochloride
ErlotinibThe Generic name of this drug
Treatment SummaryErlotinib is a medication used to treat various types of cancer, including non-small cell lung cancer and pancreatic cancer. It is sold under the brand name Tarceva and works by blocking the action of a certain protein in the body called epidermal growth factor receptor (EGFR) tyrosine kinase. In recent studies, Erlotinib has been found to also block JAK2V617F, a protein found in people with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia. This has opened up the possibility of Er
Tarcevais the brand name
Erlotinib Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tarceva
Erlotinib
2005
49
Approved as Treatment by the FDA
Erlotinib, otherwise called Tarceva, is approved by the FDA for 7 uses including Pancreatic Metastatic Cancer and Locally Advanced Pancreatic Cancer (LAPC) .Pancreatic Metastatic Cancer
Used to treat Pancreatic Metastatic Cancer in combination with Gemcitabine
Locally Advanced Pancreatic Cancer (LAPC)
Used to treat Locally Advanced Pancreatic Cancer (LAPC) in combination with Gemcitabine
Pancreatic Neoplasms
Used to treat Pancreatic Metastatic Cancer in combination with Gemcitabine
Pancreatic carcinoma
Used to treat Locally Advanced Pancreatic Cancer (LAPC) in combination with Gemcitabine
Pancreatic carcinoma
Used to treat Unresectable Pancreatic Cancer in combination with Gemcitabine
Treatment Naive
Used to treat Treatment Naive in combination with Gemcitabine
Unresectable Pancreatic Cancer
Used to treat Unresectable Pancreatic Cancer in combination with Gemcitabine
Effectiveness
How Erlotinib Hydrochloride works in the bodyErlotinib works by blocking a type of protein called tyrosine kinase that is linked to the growth of cancer cells. This protein is found in both normal and cancerous cells. Erlotinib is specific to this type of protein, so it does not affect other types of proteins.
When to interrupt dosage
The measure of Erlotinib Hydrochloride is depending on the ascertained disorder, including Pancreatic Metastatic Cancer, Malignant Neoplasms and Pancreatic carcinoma. The amount is also contingent upon the mode of delivery (e.g. Oral or Tablet - Oral) detailed in the table beneath.Condition
Dosage
Administration
Pancreatic carcinoma
, 25.0 mg, 150.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
disease progression after chemotherapy
, 25.0 mg, 150.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Pancreatic Neoplasms
, 25.0 mg, 150.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Treatment Naive
, 25.0 mg, 150.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Pancreatic carcinoma
, 25.0 mg, 150.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Malignant Neoplasms
, 25.0 mg, 150.0 mg, 100.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
There are 20 known major drug interactions with Erlotinib Hydrochloride.Common Erlotinib Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Erlotinib.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Erlotinib.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Erlotinib.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Erlotinib is combined with Arsenic trioxide.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Erlotinib.
Erlotinib Hydrochloride Toxicity & Overdose RiskOverdosing on Tarceva can lead to diarrhea, skin rashes, and an increase in liver enzyme levels. Common side effects in those with non-small cell lung cancer include rash, diarrhea, loss of appetite, and exhaustion. In those with pancreatic cancer, the most common side effects are fatigue, rash, nausea, and loss of appetite.
Erlotinib Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Erlotinib Hydrochloride?
54 active studies are being conducted to analyze the potential of Erlotinib Hydrochloride for Treatment-Naive, Metastatic Pancreatic Cancer and other Malignant Neoplasms.Condition
Clinical Trials
Trial Phases
Pancreatic carcinoma
4 Actively Recruiting
Phase 3, Phase 1, Phase 2
Pancreatic carcinoma
0 Actively Recruiting
Malignant Neoplasms
4 Actively Recruiting
Phase 1, Phase 2
disease progression after chemotherapy
0 Actively Recruiting
Treatment Naive
0 Actively Recruiting
Pancreatic Neoplasms
26 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3
Erlotinib Hydrochloride Reviews: What are patients saying about Erlotinib Hydrochloride?
5Patient Review
9/23/2011 This treatment works for me.
2.7Patient Review
11/5/2007 The side effects of this chemotherapy are really tough to deal with, but it's better than the alternative.
Patient Q&A Section about erlotinib hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is a known side effect of erlotinib?
"The following are potential side effects that may occur: diarrhea, dry skin, muscle/joint pain, mouth sores, unusual eyelash growth, or eye dryness/redness/irritation. Diarrhea can be severe and, in some cases, your doctor may prescribe medication to relieve it."
Answered by AI
Is erlotinib a chemotherapy drug?
"Erlotinib, also known as Tarceva, is a targeted cancer drug used to treat NSCLC and advanced pancreatic cancer."
Answered by AI
Can erlotinib cure pancreatic cancer?
"Overall survival in patients with advanced pancreatic cancer was significantly improved when they were given a combination of erlotinib and gemcitabine, as opposed to just gemcitabine. The HR of 0.82 means that the risk of death was reduced by 18%, or, alternately, that survival was improved by 22%."
Answered by AI
What is erlotinib hydrochloride used for?
"This medicine is for the treatment of metastatic non-small cell lung cancer in patients who have certain types of abnormal epidermal growth factor (EGFR) gene mutations. Your doctor will perform a test to see if you have these mutations before you start taking this medicine."
Answered by AI