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What is Etodolac
EtodolacThe Generic name of this drug
Treatment SummaryEtodolac is a type of anti-inflammatory drug used to reduce pain, inflammation, and fever. It works by blocking the production of a type of chemical called prostaglandin and is typically prescribed to treat rheumatoid arthritis and osteoarthritis.
Lodineis the brand name
Etodolac Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lodine
Etodolac
1993
213
Approved as Treatment by the FDA
Etodolac, also known as Lodine, is approved by the FDA for 3 uses which include Juvenile arthritis and Rheumatoid Arthritis .Juvenile arthritis
Rheumatoid Arthritis
Osteoarthritis
Effectiveness
How Etodolac Affects PatientsEtodolac is a medication used to treat osteoarthritis, rheumatoid arthritis, and acute pain. It works by blocking the body's production of chemicals that cause fever, pain, swelling, and inflammation. Etodolac comes in two forms - the S-form, which is active, and the R-form, which is inactive. It is stable and neither form will turn into the other when taken by the body.
How Etodolac works in the bodyEtodolac is an anti-inflammatory drug that works by blocking the enzyme cyclooxygenase (COX). This stops the formation of inflammatory molecules, called prostaglandins, which can cause swelling and pain. Etodolac has a special ability to target COX-2 more than COX-1. It also works on the hypothalamus, a part of the brain, to reduce fever.
When to interrupt dosage
The advised measure of Etodolac is contingent upon the diagnosed state, including Acute Pain, Heartburn and Pain. The amount of dosage is also contingent upon the mode of delivery (e.g. Oral or Tablet, film coated) specified in the table beneath.Condition
Dosage
Administration
Postoperative Pain
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Spasm
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Juvenile arthritis
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Osteoarthritis
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Chronic Back Pain
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Acute Pain
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Heartburn
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Spinal Disorders
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
gastrointestinal ulceration
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Pain
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Collagen Diseases
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Rheumatoid Arthritis
, 400.0 mg, 200.0 mg, 500.0 mg, 300.0 mg, 600.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit, Kit - Oral
Warnings
Etodolac has three prescribed contraindications, so it should not be taken when confronting circumstances in the table below.Etodolac ContraindicationsCondition
Risk Level
Notes
Coronary Artery Bypass Grafting
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Etodolac may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Etodolac may interact with Pulse Frequency
Common Etodolac Drug Interactions
Drug Name
Risk Level
Description
Macimorelin
Major
The therapeutic efficacy of Macimorelin can be decreased when used in combination with Etodolac.
Methotrexate
Major
The serum concentration of Methotrexate can be increased when it is combined with Etodolac.
Mifamurtide
Major
The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Etodolac.
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Etodolac is combined with Neomycin.
Omacetaxine mepesuccinate
Major
The risk or severity of bleeding can be increased when Etodolac is combined with Omacetaxine mepesuccinate.
Etodolac Toxicity & Overdose RiskTaking a selective COX-2 inhibitor may put some patients at risk of having a heart attack or stroke. Etodolac might also raise blood pressure and cause swelling and fluid retention. There is a risk of stomach issues such as bleeding, ulcers and holes in the stomach, as well as direct kidney injury. Severe skin reactions like exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis have been reported. Milder side effects may include abdominal pain, constipation, diarrhea, dyspepsia, flatulence, nausea, vomiting, dizziness, edema, liver problems
Etodolac Novel Uses: Which Conditions Have a Clinical Trial Featuring Etodolac?
129 active trials are being conducted to assess the capability of Etodolac in relieving Osteoarthritis (OA), spinal disorders and gastrointestinal ulceration.Condition
Clinical Trials
Trial Phases
Postoperative Pain
15 Actively Recruiting
Phase 1, Phase 4, Not Applicable, Phase 2, Phase 3
Juvenile arthritis
15 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Acute Pain
33 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
Osteoarthritis
0 Actively Recruiting
gastrointestinal ulceration
0 Actively Recruiting
Collagen Diseases
0 Actively Recruiting
Heartburn
11 Actively Recruiting
Phase 3, Phase 2, Not Applicable, Phase 4, Phase 1
Spasm
0 Actively Recruiting
Spinal Disorders
1 Actively Recruiting
Phase 3
Pain
0 Actively Recruiting
Rheumatoid Arthritis
59 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Chronic Back Pain
5 Actively Recruiting
Not Applicable
Etodolac Reviews: What are patients saying about Etodolac?
5Patient Review
7/27/2020 This treatment has been a lifesaver for me. I was in severe pain for months, and finally got some relief after being prescribed etodolac. Within days, I was feeling much better, and now after two weeks, I'm back to normal. Thank you for this medication!
5Patient Review
2/14/2020 This medication has been a game-changer for me. I was struggling with regular pain from a loss of meniscus and swelling in my left knee, but this treatment really helped to keep the swelling down and also eased some of the pressure I was feeling in my back from slipped discs. I would recommend giving it at least a month before you write it off--I'm sure you'll be pleasantly surprised with the results, as I was!
5Patient Review
1/19/2017 The medication has been effective, but I am worried about potential side effects.
5Patient Review
1/2/20155Patient Review
10/22/2015 It's been effective at managing my pain, but I worry about the potential side effects. I don't want to damage my stomach or create more problems by taking too much of it.
4.7Patient Review
4/16/2015 I injured my lower back playing basketball and, despite MRIs coming up clean, nerve tests confirmed the issue. The pain was serious enough to radiate down my entire leg. It took many months to recover, but etodolac was by far the best of the many medications I tried. Muscle relaxers did next to nothing for me, and tramadol wasn't much better. This drug allowed me to get back to work, though.
4.7Patient Review
12/20/2017 I've been using this medication for over two decades to manage my chronic pain from fibromyalgia and osteoarthritis. Recently, I started having liver problems which could be related to the Lodine. It's hard to go without it because it is effective in managing my pain, but I don't want to risk further liver damage.
4.7Patient Review
10/30/2022 I've been running for years and my body is really feeling the effects. I have arthritis in multiple joints, and this is the only treatment that has given me relief. I took it as soon as I got it from the pharmacy and by the time I got home, I could already feel a difference.
4.3Patient Review
9/11/2015 I didn't really notice much of a difference when taking this medication.
3Patient Review
11/14/2017 I was prescribed this medication for my fibromyalgia. I've found that on days where my pain is tolerable, it's an effective medication; however, on days when my pain is more severe, this medication actually makes me feel worse. This is because I can't take BC Powder to help alleviate the pain. So basically, I'm stuck with more pain and no way to relieve it. Not worth it in my opinion.
3Patient Review
12/30/2018 While this treatment does help, it only takes the edge off. I've tried other medications that have been more effective. However, those come with the cost of increased nausea and bathroom trips.
2.7Patient Review
7/7/2015 This treatment cuts down on my pain significantly, though it doesn't completely eliminate it. I've been told to take two pills a day, but even that doesn't suffice; three pills is what I need to manage the discomfort. That being said, this works better for me than Clebrex, Mobic, and Valtarin.
2.7Patient Review
8/17/2015 These pills are quite expensive, and I didn't feel that they worked any better than ibuprofen for my joint/tendon pain. It took a few hours to even start feeling some relief from the pain, whereas ibuprofin kicks in much faster. Overall, not worth the price tag in my opinion.
2.3Patient Review
2/20/2019 I took this medication for two months with no change in the severity of my pain.
2.3Patient Review
11/19/2017 I tried Etodolac for my hip pain, which was diagnosed as tendonitis. It made me feel really nauseous, but it didn't relieve the pain any more than ibuprofen or aspirin. It was better than naproxin sodium, though.
2Patient Review
11/28/2016 I found this treatment to be ineffective. Ibuprofen worked better for me than this did.
Patient Q&A Section about etodolac
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of etodolac?
"or watery eyes
The following are symptoms of an allergy: constipation, diarrhea, gas or bloating, vomiting, headache, dizziness, ringing in the ears, runny nose, or watery eyes."
Answered by AI
Is etodolac stronger than ibuprofen?
"A double-blind study comparing etodolac and ibuprofen was conducted with 1,446 patients with rheumatoid arthritis. The patients were given either 150 mg of etodolac twice daily, 500 mg of etodolac twice daily, or 600 mg of ibuprofen four times daily. The study found that both dosages of etodolac were similar in effectiveness to the ibuprofen dosage."
Answered by AI
Is etodolac the same as naproxen?
"Do etodolac and naproxen (Aleve) work in the same way? Both etodolac and naproxen (Aleve) are nonsteroidal anti-inflammatory drugs (NSAIDs) and they work by reducing pain and inflammation. Etodolac is only available with a prescription and naproxen (Aleve) is available with or without a prescription (over-the-counter)."
Answered by AI