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What is Jentadueto Xr
LinagliptinThe Generic name of this drug
Treatment SummaryLinagliptin is a medication prescribed to treat type 2 diabetes. It works differently than other drugs used to treat the same condition by not being eliminated by the kidneys and binding to proteins in the body in a concentration-dependent manner. The FDA approved linagliptin on May 2, 2011 for use in treating type 2 diabetes.
Tradjentais the brand name
Jentadueto Xr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tradjenta
Linagliptin
2011
17
Approved as Treatment by the FDA
Linagliptin, also known as Tradjenta, is approved by the FDA for 4 uses like Diet and Type 2 Diabetes Mellitus .Diet
Used to treat Diet in combination with Empagliflozin
Type 2 Diabetes Mellitus
Used to treat Type 2 Diabetes Mellitus in combination with Empagliflozin
Physical Activity
Used to treat Exercise in combination with Empagliflozin
Type 2 Diabetes
Used to treat Type 2 Diabetes Mellitus in combination with Empagliflozin
Effectiveness
How Jentadueto Xr Affects PatientsTaking 5mg of linagliptin orally will block the enzyme dipeptidyl peptidase 4 (DPP-4) for at least 24 hours. Blocking DPP-4 increases the amount of a hormone called glucagon-like peptide 1 (GLP-1) in the body, which helps to lower blood sugar levels and hemoglobin levels.
How Jentadueto Xr works in the bodyLinagliptin is a drug that slows the breakdown of two hormones, GLP-1 and GIP. This has the effect of increasing insulin release from the pancreas and decreasing the breakdown of glycogen in the liver. In turn, this helps to regulate your body's blood sugar levels.
When to interrupt dosage
The prescribed dose of Jentadueto Xr relies on the declared state, such as Physical Activity, Diet and Type 2 Diabetes. The measure of dosage is contingent upon the mode of administration (e.g. Tablet - Oral or Tablet) as outlined in the table below.Condition
Dosage
Administration
Physical Activity
2.5 mg, , 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Type 2 Diabetes
2.5 mg, , 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Diet
2.5 mg, , 5.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral
Warnings
Jentadueto Xr has six contraindications. Should any of the conditions in the following table be present, Jentadueto Xr should not be administered.Jentadueto Xr ContraindicationsCondition
Risk Level
Notes
Acute Coryza
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
Metabolic acidosis
Do Not Combine
Dialysis therapy
Do Not Combine
Kidney Failure
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Linagliptin may interact with Pulse Frequency
Common Jentadueto Xr Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Linagliptin.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Linagliptin.
Alectinib
Major
The metabolism of Alectinib can be decreased when combined with Linagliptin.
Alpelisib
Major
The metabolism of Alpelisib can be decreased when combined with Linagliptin.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Linagliptin.
Jentadueto Xr Toxicity & Overdose RiskThe dose of linagliptin does not need to be adjusted for factors such as race, age, weight, sex, or any kidney or liver impairments. While studies of safety and effectiveness in children were not done during the original approval process, recent clinical trials have shown that linagliptin is safe for kids aged 10-18. When tested on animals, linagliptin caused an increased risk of lymphoma in female rats when taken at over 200 times the normal dose. Other than this, the drug was not shown to be damaging to fertility, cause mutations, or affect cell growth.
Jentadueto Xr Novel Uses: Which Conditions Have a Clinical Trial Featuring Jentadueto Xr?
196 active trials are currently being conducted to examine the potential of Jentadueto Xr to impact Physical Activity, Type 2 Diabetes and Dietary Habits.Condition
Clinical Trials
Trial Phases
Type 2 Diabetes
154 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Diet
6 Actively Recruiting
Not Applicable
Physical Activity
39 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1
Patient Q&A Section about jentadueto xr
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is JENTADUETO XR used for?
"JENTADUETO and JENTADUETO XR tablets can help improve glycemic control in adults with type 2 diabetes mellitus when used with diet and exercise."
Answered by AI
Is Jentadueto the same as metformin?
"Jentadueto is a combination of the oral diabetes medicines linagliptin and metformin. These drugs work together to control blood sugar levels by decreasing glucose production in the liver and reducing absorption of glucose by the intestines."
Answered by AI
How much does Jentadueto cost?
"The cost of Jentadueto will vary depending on the pharmacy, but is typically around $541 for 60 tablets. This price is only for cash paying customers and does not apply to those with insurance plans."
Answered by AI
What are the side effects of JENTADUETO XR?
"The common cold can cause a runny or stuffy nose, diarrhea, cough, hypersensitivity (hives, skin swelling, bronchospasm), decreased appetite, nausea, vomiting, itching, and fatigue."
Answered by AI