Lialda

Q: What exactly does Lialda do?

<p>This medication is used to treat <a href="https://www.withpower.com/clinical-trials/ulcerative-colitis">ulcerative colitis</a>, a bowel disease that causes symptoms like diarrhea, rectal bleeding, and stomach <a href="https://www.withpower.com/clinical-trials/pain">pain</a>. Mesalamine, a drug in the aminosalicylate class, works by reducing swelling in the colon.</p>

Proctitis, Proctocolitis, Colitis, Ulcerative + 2 more

Treatment

1 FDA approval

0 Active Studies for Lialda

Treatment for

Proctitis

What is Lialda

MesalazineThe Generic name of this drug

Treatment SummaryMesalazine is an anti-inflammatory medication related to aspirin. It is used to treat and prevent remission of ulcerative colitis and may reduce the risk of colorectal cancer. It has historically been difficult to stabilize but research initiatives have developed more stable formulations such as Asacol and Pentasa. Research into new methods to stabilize mesalazine continues.

Rowasais the brand name

image of different drug pills on a surface

Lialda Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Rowasa

Mesalazine

1988

107

Approved as Treatment by the FDA

Mesalazine, otherwise called Rowasa, is approved by the FDA for 1 uses which include Crohn Disease .

Crohn Disease

Effectiveness

How Lialda Affects PatientsMesalazine is one of two parts of the drug sulphasalazine. It is believed to reduce inflammation in the body by blocking the production of substances called prostaglandins and leukotrienes, and by removing free radicals. It works mainly at the site of inflammation rather than throughout the body. Studies in mice and guinea pigs have shown that mesalazine can be as effective as other drugs in reducing colitis and reversing the effects of inflammation.

How Lialda works in the bodyThe exact way mesalazine works is unclear, but it is thought to reduce inflammation in the colon by blocking the production of prostaglandins and other molecules that promote inflammation. It also stops the production of molecules related to Nuclear Factor kappa B which help create pro-inflammatory cytokines. Mesalazine also activates PPAR gamma receptors, and it has been shown to reduce leukocyte migration, cytokine production, and free radical formation.

When to interrupt dosage

The measure of Lialda is contingent upon the diagnosed condition. The amount of dosage also varies, as per the technique of delivery featured in the table below.

Condition

Dosage

Administration

Proctitis

400.0 mg, , 1200.0 mg, 800.0 mg, 400.0 mg/mL, 500.0 mg, 1000.0 mg, 375.0 mg, 250.0 mg, 10.0 mg/mL, 40.0 mg/mL, 0.4 mg/mg, 20.0 mg/mL, 200.0 mg/mL, 1000.0 mg/pump actuation, 0.2 mg/mg

Oral, Tablet, delayed release - Oral, , Tablet, delayed release, Capsule, delayed release - Oral, Capsule, delayed release, Rectal, Enema, Enema - Rectal, Kit, Tablet, Tablet - Oral, Capsule - Oral, Capsule, Suspension, Suspension - Rectal, Suppository, Suppository - Rectal, Capsule, extended release, Capsule, extended release - Oral, Tablet, extended release, Tablet, extended release - Oral, Enema; Liquid, Enema; Liquid - Rectal, Tablet, Delayed Release - Oral, Tablet, Delayed Release, Kit - Rectal

Proctocolitis

400.0 mg, , 1200.0 mg, 800.0 mg, 400.0 mg/mL, 500.0 mg, 1000.0 mg, 375.0 mg, 250.0 mg, 10.0 mg/mL, 40.0 mg/mL, 0.4 mg/mg, 20.0 mg/mL, 200.0 mg/mL, 1000.0 mg/pump actuation, 0.2 mg/mg

Colitis, Ulcerative

400.0 mg, , 1200.0 mg, 800.0 mg, 400.0 mg/mL, 500.0 mg, 1000.0 mg, 375.0 mg, 250.0 mg, 10.0 mg/mL, 40.0 mg/mL, 0.4 mg/mg, 20.0 mg/mL, 200.0 mg/mL, 1000.0 mg/pump actuation, 0.2 mg/mg

Ulcerative Colitis

400.0 mg, , 1200.0 mg, 800.0 mg, 400.0 mg/mL, 500.0 mg, 1000.0 mg, 375.0 mg, 250.0 mg, 10.0 mg/mL, 40.0 mg/mL, 0.4 mg/mg, 20.0 mg/mL, 200.0 mg/mL, 1000.0 mg/pump actuation, 0.2 mg/mg

Crohn Disease

400.0 mg, , 1200.0 mg, 800.0 mg, 400.0 mg/mL, 500.0 mg, 1000.0 mg, 375.0 mg, 250.0 mg, 10.0 mg/mL, 40.0 mg/mL, 0.4 mg/mg, 20.0 mg/mL, 200.0 mg/mL, 1000.0 mg/pump actuation, 0.2 mg/mg

Warnings

Lialda Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Mesalazine may interact with Pulse Frequency

There are 20 known major drug interactions with Lialda.

Common Lialda Drug Interactions

Drug Name

Risk Level

Description

Macimorelin

Major

The therapeutic efficacy of Macimorelin can be decreased when used in combination with Mesalazine.

Methotrexate

Major

The serum concentration of Methotrexate can be increased when it is combined with Mesalazine.

Mifamurtide

Major

The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Mesalazine.

Neomycin

Major

The risk or severity of nephrotoxicity can be increased when Mesalazine is combined with Neomycin.

Omacetaxine mepesuccinate

Major

The risk or severity of bleeding can be increased when Mesalazine is combined with Omacetaxine mepesuccinate.

Lialda Toxicity & Overdose RiskA two-year study of rats showed no increase in the incidence of tumors when given up to 320mg/kg/day of mesalazine. The drug was not found to be mutagenic or cause fertility issues in either males or females. If a person overdoses on mesalazine, they may experience nausea, vomiting, rapid breathing, tinnitus, headache, confusion, seizures, and imbalances in their blood and electrolytes. There is no antidote for mesalazine overdose, so treatment typically includes removing the drug from the body and correcting any electrolyte or fluid imbalances. People with impaired renal function or a

image of a doctor in a lab doing drug, clinical research

Lialda Novel Uses: Which Conditions Have a Clinical Trial Featuring Lialda?

Presently, there are 96 studies being conducted to assess the effectiveness of Lialda in treating Ulcerative Colitis.

Condition

Clinical Trials

Trial Phases

Proctitis

0 Actively Recruiting

Crohn Disease

0 Actively Recruiting

Proctocolitis

0 Actively Recruiting

Colitis, Ulcerative

0 Actively Recruiting

Ulcerative Colitis

0 Actively Recruiting

Lialda Reviews: What are patients saying about Lialda?

5Patient Review

4/20/2016

Lialda for Ulcerative Colitis currently Without Symptoms

I had to switch from Asacol to this when the former was taken off the market, but unfortunately it didn't work at all for me. My doctor said that about half of his patients taking Lialda found that it was ineffective.

5Patient Review

4/28/2019

Lialda for Crohn's Disease

This medication made my life so much better. It helped with my ulcer and I didn't need any blood transfusions. Unfortunately, it's really expensive and I can't afford it anymore.

4.7Patient Review

6/9/2017

Lialda for Ulcerative Colitis currently Without Symptoms

Lilada is highly effective at reducing symptoms. However, after taking it for two months I experienced hair loss, so I had to stop taking the medication.

4.7Patient Review

12/16/2014

Lialda for Ulcerative Colitis currently Without Symptoms

Unfortunately, I had a negative reaction to this drug both times I took it. It was so bad that it put me in bed for two days each time. I'm sure it's fine for most people, but beware if you think you might be sensitive to it.

4.7Patient Review

6/9/2015

Lialda for Ulcerative Colitis currently Without Symptoms

I was prescribed this alongside Humira and it has done wonders for my condition.

4.7Patient Review

6/3/2016

Lialda for Ulcerative Colitis currently Without Symptoms

I put on a lot of weight while taking this medication, even though I hadn't been experiencing any symptoms prior.

4.3Patient Review

8/2/2019

Lialda for Ulcerative Colitis currently Without Symptoms

Though it's helped, I have experienced some joint pain as a result of taking this medication. It started in my knees and ankles, which was difficult because I love hiking. However, after a month the pain subsided. Now I'm experiencing wrist and hand joint pain.

4Patient Review

12/3/2015

Lialda for Ulcerative Colitis currently Without Symptoms

I experienced hair loss as a side-effect of this medication, which was disappointing. However, it was otherwise effective in reducing flare-ups and eliminating blood in my stool. A more minor side-effect was gas.

3.7Patient Review

3/12/2015

Lialda for Ulcerated Colon

Lialda was very effective at treating my ulcerative colitis. I've been symptom-free for six months now, with only the occasional need to use the restroom when urgency strikes.

3.3Patient Review

10/25/2015

Lialda for Ulcerative Colitis currently Without Symptoms

Last year, I was diagnosed with "undefinitive UC" by my doctor. They couldn't tell if it was UC or Chrons, so they started me on Lialda. I began with 4 pills a day and eventually went down to 2. Since then, I've broken my shoulder and foot which required me to take steroids. As a result of the steroids, I gained weight from my shoulders to my hips and can't seem to lose it. Both of my shoulders ache most of the time, but I also work on a computer for most of the day. Overall, it is easy to maintain with Lial

3Patient Review

8/10/2016

Lialda for Crohn's Disease

I've been using Lialda for two months now, and it's helped me a lot. The only downside is that I've gained some weight; not sure if that's the fault of the medication or not, but it's still been annoying. My hair also seems thinner to me. Overall, though, I'm pretty happy with this product and would recommend it to others!

2Patient Review

8/16/2014

Lialda for Ulcerative Colitis currently Without Symptoms

1.7Patient Review

9/1/2014

Lialda for Ulcerated Colon

I'm allergic to sulfa, and this med contains sulfasalazine. Unfortunately, I didn't feel well at all the three days I took it and developed a rash and blister as a result.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about lialda

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of taking Lialda?

"The following are potential side effects of the medication: hair loss, joint pain, dizziness, headache, flatulence, increased liver enzymes, abdominal pain, diarrhea."

Answered by AI

Is Lialda safe for long term use?

"Lialda is federally approved in the United States for helping adults maintain mild to moderate remission from ulcerative colitis. This involves taking the medication on a long-term basis, even when asymptomatic, in order to keep the disease controlled and prevent symptoms from returning."

Answered by AI

What exactly does Lialda do?

"This medication is used to treat ulcerative colitis, a bowel disease that causes symptoms like diarrhea, rectal bleeding, and stomach pain. Mesalamine, a drug in the aminosalicylate class, works by reducing swelling in the colon."

Answered by AI