Tadalafil for COPD with Pulmonary Hypertension
This trial is testing whether tadalafil can help Veterans with COPD and high blood pressure in the lungs by reducing shortness of breath and improving overall health. The drug works by relaxing blood vessels to improve blood flow. The study will compare tadalafil to another group over several months to see if it makes a significant difference in symptoms and quality of life. Tadalafil received FDA approval in 2009 for the treatment of pulmonary arterial hypertension (PAH) and has shown to improve exercise capacity and quality of life in patients.
Radioisotope Therapy
Rhenium Re 188 P2045 for Lung Cancer
This trial tests a new drug called Rhenium Re 188 P2045 on lung cancer patients. It aims to find a safe dose and check if it helps reduce tumors. Patients are monitored closely for side effects and tumor response.
Tyrosine Kinase Inhibitor
Cabozantinib for Non-Small Cell Lung Cancer
This trial will help us understand if cabozantinib can help patients with gene RET, ROS1, or NTRK fusion or increased MET or AXL activity by inhibiting these genes that lead to lung cancer cell growth.
Proton Beam Therapy
Image-Guided Radiation Therapy for Lung Cancer
This trial is testing a new way of delivering radiation dose by image-guided, intensity-modulated photon or proton beam radiation therapy to patients with stage II-IIIB non-small cell lung cancer.
Popular Filters
Trials for NSCLC Patients
Brachytherapy
CivaSheet for Lung Cancer
This trial will test a new cancer treatment device to see if it is safe and effective. The device uses active components of standard devices in a new way, which may reduce the amount of radiation to healthy tissue while giving a therapeutic dose to diseased tissue.
Kinase Inhibitor
Tepotinib for Lung Cancer
This trial will study the effects of tepotinib on lung cancer growth and spread, as well as safety, side effects, and quality of life. Pharmacogenetic research may also be conducted to study how genes impact the effectiveness of the drug.
Trials for Non-Small Cell Lung Cancer Patients
Brachytherapy
CivaSheet for Lung Cancer
This trial will test a new cancer treatment device to see if it is safe and effective. The device uses active components of standard devices in a new way, which may reduce the amount of radiation to healthy tissue while giving a therapeutic dose to diseased tissue.
Kinase Inhibitor
Tepotinib for Lung Cancer
This trial will study the effects of tepotinib on lung cancer growth and spread, as well as safety, side effects, and quality of life. Pharmacogenetic research may also be conducted to study how genes impact the effectiveness of the drug.
Trials for EGFR Positive Patients
Tyrosine Kinase Inhibitor
Erlotinib for Non-Small Cell Lung Cancer
This trial compares erlotinib hydrochloride to observation in treating patients with resected stage IB-IIIA non-small cell lung cancer. Erlotinib hydrochloride may stop tumor cell growth by blocking enzymes needed for cell growth.
PD-L1 Inhibitor
Durvalumab + Olaparib + Cediranib for Ovarian Cancer
This trial is testing the combination of Durvalumab, Olaparib, and Cediranib in adults with advanced or recurrent ovarian cancer to see how well they tolerate it and if it is effective in treating the cancer.
Trials for ALK Positive Patients
Tyrosine Kinase Inhibitor
Alectinib vs Crizotinib for Non-Small Cell Lung Cancer
This trial compares two medications, alectinib and crizotinib, for treating a specific type of advanced lung cancer. The patients have not received any prior treatment for their cancer. Both drugs work by blocking a protein that helps the cancer cells grow. Alectinib has shown superior effectiveness and fewer side effects compared to crizotinib in treating this type of lung cancer.
Kinase Inhibitor
Ceritinib + Everolimus for Lung Cancer
This trial is testing the side effects and best dosage of ceritinib and everolimus for treating patients with solid tumors that have spread from the original site. Ceritinib and everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Tyrosine Kinase Inhibitor
Crizotinib for Non-Small Cell Lung Cancer
This trial studies crizotinib for patients with stage IB-IIIA NSCLC who have had surgery and have an ALK fusion mutation. Crizotinib may stop the growth of tumor cells by blocking the ALK protein from working.
Tyrosine Kinase Inhibitor
Erlotinib for Non-Small Cell Lung Cancer
This trial compares erlotinib hydrochloride to observation in treating patients with resected stage IB-IIIA non-small cell lung cancer. Erlotinib hydrochloride may stop tumor cell growth by blocking enzymes needed for cell growth.
Phase 3 Trials
Alkylating agents
Radiation + Chemotherapy for Small Cell Lung Cancer
This trial is testing different radiation therapy regimens to see which is more effective in treating patients with limited-stage small cell lung cancer when given together with chemotherapy.
Proton Beam Therapy
Photon vs Proton Radiation for Non-Small Cell Lung Cancer
This trial is comparing two types of radiation therapy to see which is more effective in treating patients with stage II-IIIB non-small cell lung cancer- proton chemoradiotherapy versus photon chemoradiotherapy.
Procedure
Extracorporeal Photopheresis for Bronchiolitis Obliterans Syndrome
This trial is studying how well Extracorporeal Photopheresis works in treating patients with either refractory or newly diagnosed Bronchiolitis Obliterans Syndrome after lung transplantation.
Trials With No Placebo
Procedure
Cryobiopsy vs Forceps Biopsy for Lung Disease
This trial compares a new method to a standard one for lung biopsies. It targets patients needing lung tissue samples, aiming to improve sample quality and reduce complications. The new method works by freezing and removing tissue, providing larger and higher-quality samples with a good safety and cost-benefit profile.
Brachytherapy
CivaSheet for Lung Cancer
This trial will test a new cancer treatment device to see if it is safe and effective. The device uses active components of standard devices in a new way, which may reduce the amount of radiation to healthy tissue while giving a therapeutic dose to diseased tissue.
Kinase Inhibitor
Tepotinib for Lung Cancer
This trial will study the effects of tepotinib on lung cancer growth and spread, as well as safety, side effects, and quality of life. Pharmacogenetic research may also be conducted to study how genes impact the effectiveness of the drug.
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Frequently Asked Questions
Introduction to lung
What are the top hospitals conducting lung research?
When it comes to cutting-edge clinical trials in the realm of lung diseases, hospitals across the United States are making significant strides. In New york City, Memorial Sloan Kettering Cancer Center is blazing a trail with its five current active lung trials. While this institution may not have a historical record of past lung trials, their dedication to advancing research in this field is evident. Similarly, M D Anderson Cancer Center in Houston is also at the forefront of innovative lung trials with an equal number of ongoing studies and no previous recorded lung trials.
Meanwhile, on the west coast, PCR Oncology located in Arroyo Grande joins the ranks by conducting five active clinical trials for individuals affected by pulmonary conditions but likewise lacks any prior recorded experiments pertaining to lungs. The University of California Davis Comprehensive Cancer Center in Sacramento reinforces Northern Californian contributions with five currently running lung-related clinical investigations while Washington University School of Medicine based out in St. Louis adds its expertise into mix as well through their own set of five currently underway yet lacking background-controlled comparisons or preceding relevant testing done historically.
These top-tier medical institutions illustrate that groundbreaking advancements do not always require extensive historical data; instead, they highlight an unwavering commitment to progress and improvement within specific areas such as respiratory health. By focusing on these crucial studies today, we pave the way for better treatments and outcomes tomorrow - ensuring brighter horizons for those suffering from lung diseases around the world.
Which are the best cities for lung clinical trials?
When it comes to lung clinical trials, several cities in the United States have emerged as leading centers for research and treatment. Anchorage, Alaska boasts 27 active trials focusing on promising treatments such as Nivolumab, Erlotinib Hydrochloride, and Pembrolizumab. Similarly, Los Angeles, California offers 26 ongoing studies investigating therapeutic options like Erlotinib Hydrochloride and immunotherapies such as Nivolumab and Pembrolizumab. New york City stands out with its 24 active trials exploring innovative treatments including Stereotactic Body Radiation Therapy and targeted therapies like Nintedanib. Finally, Sacramento, California and Chicago, Illinois also contribute significantly to lung clinical trial research with their respective portfolios of 21 and 20 ongoing studies. These cities serve as vital hubs for patients seeking access to groundbreaking lung cancer treatments through participation in clinical trials.
Which are the top treatments for lung being explored in clinical trials?
In ongoing clinical trials, the top treatments being explored for lung cancer display great potential in advancing patient care. One of these leading therapies is durvalumab, an immunotherapy drug that targets specific proteins on cancer cells and has shown promise in multiple studies. Another noteworthy treatment is osimertinib, a targeted therapy designed to inhibit certain genetic mutations commonly found in non-small cell lung cancer (NSCLC). Additionally, lorlatinib, another targeted therapy, has demonstrated encouraging results in trials by targeting specific gene alterations prevalent in metastatic NSCLC patients. These innovative treatments offer hope for improving outcomes and quality of life for individuals diagnosed with lung cancer.
What are the most recent clinical trials for lung?
Exciting advancements are being made in the field of lung cancer research through recent clinical trials. One such trial focuses on the effectiveness of cemiplimab, a potential treatment for lung cancer patients in Phase 2. Another study aims to determine optimal dosages for non-small cell lung cancer (NSCLC) treatment during its Phase 1 dose-finding stage. Additionally, promising results have been observed when combining lorlatinib and ramucirumab as part of a Phase 1 and Phase 2 trial for lung cancer. Further investigation is also underway regarding the potential benefits of tocilizumab in treating this devastating disease, with an ongoing Phase 1 and Phase 2 study. Lastly, furmonertinib at a dosage of 240 mg is undergoing evaluation in a large-scale phase III trial targeting specific subsets within the population affected by lung cancer. These cutting-edge clinical trials offer hope for improved treatments and outcomes for individuals facing this challenging condition.
What lung clinical trials were recently completed?
Recently concluded clinical trials in the field of lung research have yielded significant advancements. These studies demonstrate the commitment of researchers to finding innovative treatments for lung-related conditions. Prominently, a trial led by the Mayo Clinic focused on investigating the effectiveness and safety of a novel therapy targeting specific mutations found in non-small cell lung cancer patients. Furthermore, another trial conducted at Stanford University explored the potential benefits of immunotherapy in individuals with advanced stage small cell lung cancer. These recent breakthroughs provide hope for patients battling these challenging diseases and pave the way for further progress in improving outcomes and quality of life.