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What is Natazia
DienogestThe Generic name of this drug
Treatment SummaryEstradiol Valerate (E2V) is a form of the hormone estradiol, which is naturally produced by the body. It is a pro-drug, meaning it must be converted into estradiol in order to be effective. Estradiol Valerate is available as a prescription medication and is used to treat symptoms of menopause such as hot flashes, vaginal dryness, mood changes, irregular menses, chills, and sleeping problems. In addition, it can also be used to treat hypogonadism, castration, and prostate cancer. Estradiol Valerate is usually administered
Nataziais the brand name
Natazia Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Natazia
Dienogest
2010
3
Approved as Treatment by the FDA
Dienogest, also known as Natazia, is approved by the FDA for 7 uses like Pain and Endometriosis .Pain
Helps manage Pain
Endometriosis
Helps manage Endometriosis
Hypermenorrhea
Used to treat Hypermenorrhea in combination with Estradiol valerate
Chronic Pain
Helps manage Pain
Endometriosis
Helps manage Endometriosis
Menorrhagia
Used to treat Hypermenorrhea in combination with Estradiol valerate
Oral Contraceptives
Used to treat Oral Contraceptives in combination with Estradiol valerate
Effectiveness
How Natazia Affects PatientsEstrogen has powerful effects on the body, and works by attaching to certain receptors in the breasts, uterus, ovaries, skin, prostate, bone, fat and brain. These receptors are known as Estrogen Receptor Alpha (ERα) and Estrogen Receptor Beta (ERβ). Estrogen also attaches to a newly recognized receptor called G Protein-coupled Estrogen Receptor (GPER), which is responsible for its fast-acting effects.
How Natazia works in the bodyEstradiol is a hormone that binds to receptors in certain cells and organs, such as the female reproductive organs and breasts. When it binds to these receptors, it triggers the production of certain proteins. These proteins help to regulate processes like the production of other hormones and sex-binding proteins. This process helps to reverse some of the symptoms of menopause, which are caused by a decrease in estrogen.
When to interrupt dosage
The measure of Natazia is contingent upon the diagnosed situation, such as serious menopausal vulvovaginal degeneration, Menopausal Symptoms and Menorrhagia. The dosage also differs in accordance with the technique of delivery featured in the table below.Condition
Dosage
Administration
Chronic Pain
, 2.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, Tablet - Oral, Kit
Birth Control
, 2.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, Tablet - Oral, Kit
Menorrhagia
, 2.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, Tablet - Oral, Kit
Oral Contraceptives
, 2.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, Tablet - Oral, Kit
Hormonal Contraception
, 2.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, Tablet - Oral, Kit
Endometriosis
, 2.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, Tablet - Oral, Kit
Warnings
Natazia has eleven contraindications, so abstaining from its use is advised if any of the conditions in the following table are present.Natazia ContraindicationsCondition
Risk Level
Notes
Breast
Do Not Combine
Vaginal Hemorrhage
Do Not Combine
Ocular vascular disorder
Do Not Combine
Heart Disease
Do Not Combine
Arteriosclerosis
Do Not Combine
Neoplasms, Hormone-Dependent
Do Not Combine
Breast Cancer
Do Not Combine
Liver diseases
Do Not Combine
Venous Thromboembolism
Do Not Combine
Breast Milk Production
Do Not Combine
Diabetes Mellitus
Do Not Combine
Liver Neoplasms
Do Not Combine
Migraine Disorders
Do Not Combine
Common Natazia Drug Interactions
Drug Name
Risk Level
Description
Tranexamic acid
Major
Dienogest may increase the thrombogenic activities of Tranexamic acid.
Acetohexamide
Minor
The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Dienogest.
Acrivastine
Minor
Dienogest may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Dienogest may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Almasilate
Minor
Dienogest may decrease the excretion rate of Almasilate which could result in a higher serum level.
Natazia Novel Uses: Which Conditions Have a Clinical Trial Featuring Natazia?
27 active studies are currently examining the potential of Natazia to alleviate Irregular Menstruation, reduced reproductive organ functionality and female Neutering.Condition
Clinical Trials
Trial Phases
Hormonal Contraception
0 Actively Recruiting
Birth Control
25 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1
Chronic Pain
149 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Endometriosis
29 Actively Recruiting
Early Phase 1, Phase 2, Phase 3, Not Applicable, Phase 4
Oral Contraceptives
1 Actively Recruiting
Not Applicable
Menorrhagia
0 Actively Recruiting
Natazia Reviews: What are patients saying about Natazia?
5Patient Review
2/13/2015 This pill has been great for me. I was on Yasmin for three years and made the switch to this one. So far, I've lost weight and find that it's much more accurate than the last pill I was taking. Plus, I get my period on the first placebo pill with no cramping!
5Patient Review
2/22/2016 This pill has truly been a life-changer for me. I no longer have to worry about heavy periods or leakage, and my sex drive has increased.
5Patient Review
1/31/2018 I've tried a lot of different birth controls, and this is by far the best one I've used. There are no negative side effects like there are with other hormone-based options.
5Patient Review
6/11/2015 Prior to taking Natazia, I was on Junel Fe. Unfortunately, that led to me having really bad yeast infections and BV. Thankfully, my gyno switched me over to this medication and I haven't had any problems since! Not only that, but I also don't get my period anymore. This has been a total life-saver for me.
5Patient Review
7/11/2016 This small pill has made a big difference in my life. My periods used to last for 10 days and be very painful, with migraines, but now they only last for 2 days (sometimes even less) and the cramps are much less severe. I haven't had any major side effects either, which is great.
5Patient Review
5/5/2016 This is the best treatment I've found for PCOS in terms of controlling my periods, cramps, and some hormones.
5Patient Review
11/21/2014 I cannot recommend this BC enough. It has completely changed my life for the better by essentially getting rid of my period. I also don't have to worry about any mood swings, cramps, weight gain, or side effects.
4.7Patient Review
8/31/2014 I've been using Natazia for a little over two years now and it's helped me out a lot. Not only did it help clear up my acne, but I also haven't gotten pregnant while using it. The downside is that it made me gain fifteen pounds and my breasts went up one or two sizes (C-D/DD), but the positives outweigh the negatives in my opinion.
4Patient Review
2/17/2015 Good birth control pill, though it did cause some vaginal dryness. I only experienced this on the days when I was taking the two white pills. Another issue I had was that, if I missed a pill, I would lightly bleed for nine days straight. This happened to me twice. Luckily, I haven't had any problems since then because I am very good about taking them as prescribed. Additionally, my sex drive decreased slightly during the second and third week of taking this medication.
4Patient Review
11/24/2014 I've lost 13 pounds in the two months since I started taking Natazia.
3.3Patient Review
8/26/2015 Since I started taking Natazia, my periods have been lighter and shorter. However, I've gained 40lbs, have a headache every day, mood swings and low sex drive. After I complete this pack, I will change. Emotionally, I feel as if I have lost control and the headaches takes away from my quality of life--in addition to the other issues mentioned.
Patient Q&A Section about natazia
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Natazia generic for?
"Estradiol valerate and estradiol valerate/dienogest (Natazia) are the first four-phasic oral contraceptives. These drugs are taken orally and work by inhibiting ovulation and fertilization."
Answered by AI
What kind of birth control is Natazia?
"The OC Natazia is the only one with 4-phasic dosing that contains both estrogen and progestin. The estrogen is called estradiol valerate and the progestin is dienogest."
Answered by AI
What are the side effects of Natazia?
"If you have any of these side effects while taking Natazia, stop taking the drug and call your doctor immediately: irregular or light menstrual periods, nausea (especially when you first start taking Natazia), vomiting, breast pain/tenderness/enlargement, stomach cramping or bloating, freckles or darkening of facial skin, weight gain, problems with contact lenses."
Answered by AI
How long does it take for Natazia to work?
"If you're switching from using a vaginal ring or transdermal patch to Natazia, start taking Natazia on the day you remove the ring or patch. For the first 9 days you're taking Natazia, use a non-hormonal form of contraception like condoms with spermicide in addition."
Answered by AI