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What is Primaquine
PrimaquineThe Generic name of this drug
Treatment SummaryAn aminoquinoline, chloroquine is an oral medication used to completely cure malaria caused by either the vivax or ovale parasite. It can also be used to prevent the transmission of falciparum malaria by people traveling to areas where the disease is present. Common side effects of chloroquine include anemia and gastrointestinal issues.
Primaquine Phosphateis the brand name
Primaquine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Primaquine Phosphate
Primaquine
2011
14
Approved as Treatment by the FDA
Primaquine, also known as Primaquine Phosphate, is approved by the FDA for 2 uses such as Malaria caused by Plasmodium ovale and Malaria .Malaria caused by Plasmodium ovale
Malaria
Effectiveness
How Primaquine Affects PatientsPrimaquine is a medication used to treat malaria. It works by interrupting a part of the malaria parasite that provides it with energy, which stops the infection and allows the person to recover. Primaquine is not used for prevention, only for treatment. It kills the intrahepatic form of malaria and stops relapses from occurring. It also kills all forms of malaria parasites, but is always used with another medication (called a blood schizonticide) and never alone. Primaquine can also stop the spread of malaria by killing gametocytes.
How Primaquine works in the bodyPrimaquine works by either creating oxygen molecules in the body or disrupting the electron transport of parasites. It is also thought to affect how protozoal DNA works.
When to interrupt dosage
The measure of Primaquine is contingent upon the diagnosed problem, including Malaria, prophylaxis of Malaria and Malaria brought about by Plasmodium ovale. The quantity of dosage is determined by the method of administration (e.g. Tablet, film coated - Oral or Oral) recorded in the table underneath.Condition
Dosage
Administration
Malaria
, 26.3 mg, 15.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
prophylaxis of Malaria
, 26.3 mg, 15.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Malaria caused by Plasmodium ovale
, 26.3 mg, 15.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Malaria
, 26.3 mg, 15.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
HIV
, 26.3 mg, 15.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Pneumocystis Jirovecii Pneumonia
, 26.3 mg, 15.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Warnings
Primaquine has eight contraindications, thus it should not be utilized when experiencing any of the conditions enumerated in the table below.Primaquine ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Systemic Diseases
Do Not Combine
Rheumatoid Arthritis
Do Not Combine
hemolytic agents
Do Not Combine
Lupus Erythematosus
Do Not Combine
Acute Coryza
Do Not Combine
Common Primaquine Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Primaquine.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Primaquine.
Acepromazine
Major
The risk or severity of QTc prolongation can be increased when Primaquine is combined with Acepromazine.
Aceprometazine
Major
The risk or severity of QTc prolongation can be increased when Primaquine is combined with Aceprometazine.
Acetophenazine
Major
The risk or severity of QTc prolongation can be increased when Primaquine is combined with Acetophenazine.
Primaquine Novel Uses: Which Conditions Have a Clinical Trial Featuring Primaquine?
123 active studies are investigating the novel utilization of Primaquine to treat HIV, Malaria and Pneumocystis Jirovecii Pneumonia.Condition
Clinical Trials
Trial Phases
HIV
135 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
Malaria
0 Actively Recruiting
Malaria
0 Actively Recruiting
prophylaxis of Malaria
0 Actively Recruiting
Pneumocystis Jirovecii Pneumonia
1 Actively Recruiting
Phase 3
Malaria caused by Plasmodium ovale
0 Actively Recruiting
Patient Q&A Section about primaquine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the side effect of primaquine?
"You may experience nausea, vomiting, dizziness, stomach upset, and abdominal cramps. If any of these symptoms persist or worsen, tell your doctor or pharmacist."
Answered by AI
Is primaquine an antibiotic?
"Primaquine is an antibiotic used to treat various types of infections. It can be co-administered with clindamycin for the treatment of Pneumocystis carinii pneumonia (PCP)."
Answered by AI
Why primaquine is given for 14 days?
"Plasmodium vivax infections are a major problem worldwide when it comes to malaria. The World Health Organization recommends a 14-day course of primaquine in order to get rid of the liver stage of the parasite and prevent the disease from coming back."
Answered by AI
Is primaquine the same as chloroquine?
"Chloroquine is an effective drug against the asexual stages of the parasite, while primaquine is less effective but is the only drug that kills the dormant liver stage parasites and prevents relapse."
Answered by AI