Stavudine

HIV
Treatment
1 FDA approval
20 Active Studies for Stavudine

What is Stavudine

StavudineThe Generic name of this drug
Treatment SummaryA dideoxynucleoside analog is a type of medication that prevents the virus that causes HIV from replicating. It works by stopping the reverse transcriptase enzyme from making copies of the virus.
Zeritis the brand name
image of different drug pills on a surface
Stavudine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zerit
Stavudine
1994
45

Approved as Treatment by the FDA

Stavudine, commonly known as Zerit, is approved by the FDA for 1 uses including HIV .
HIV
Used in combination with Stavudine to help manage Human Immunodeficiency Virus (HIV) Infections

Effectiveness

How Stavudine Affects PatientsStavudine is a drug used to treat HIV-1. It works by changing the structure of an enzyme called reverse transcriptase, which is used by the virus to replicate. This change prevents the virus from making more copies of itself, blocking its growth. Stavudine is changed into an active form in the body, and it stops the virus from forming a link that is needed for it to make more copies of itself.
How Stavudine works in the bodyStavudine stops HIV from replicating by blocking an enzyme it needs to make copies of itself. This is done by preventing the enzyme from attaching onto a molecule it needs to create a copy.

When to interrupt dosage

The measure of Stavudine is contingent upon the diagnosed issue. The amount of dosage fluctuates, depending on the delivery technique (e.g. Oral or Capsule, gelatin coated - Oral) detailed in the table beneath.
Condition
Dosage
Administration
HIV
15.0 mg, , 20.0 mg, 30.0 mg, 40.0 mg, 1.0 mg/mL, 200.0 mg, 100.0 mg, 75.0 mg, 37.5 mg, 50.0 mg
, Powder, for solution - Oral, Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Powder, for solution, Capsule, Capsule - Oral, Solution, Solution - Oral, For solution - Oral, For solution, Capsule, extended release, Capsule, extended release - Oral

Warnings

There are 20 known major drug interactions with Stavudine.
Common Stavudine Drug Interactions
Drug Name
Risk Level
Description
Acepromazine
Minor
Stavudine may increase the neurotoxic activities of Acepromazine.
Aceprometazine
Minor
Stavudine may increase the neurotoxic activities of Aceprometazine.
Acetophenazine
Minor
Stavudine may increase the neurotoxic activities of Acetophenazine.
Alimemazine
Minor
Stavudine may increase the neurotoxic activities of Alimemazine.
Amineptine
Minor
Stavudine may increase the neurotoxic activities of Amineptine.
Stavudine Toxicity & Overdose RiskStavudine (ZERIT) may cause a tingling, burning, or numbness in the hands and feet, which is a condition known as peripheral neuropathy. Severe cases may lead to lactic acidosis, enlarged and inflamed liver, and even liver failure.
image of a doctor in a lab doing drug, clinical research

Stavudine Novel Uses: Which Conditions Have a Clinical Trial Featuring Stavudine?

Currently, 122 active studies are investigating the utility of Stavudine in the management of Human Immunodeficiency Virus (HIV).
Condition
Clinical Trials
Trial Phases
HIV
119 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 3, Phase 4, Early Phase 1

Stavudine Reviews: What are patients saying about Stavudine?

5Patient Review
3/26/2014
Stavudine for HIV
This treatment really helped me. I'm grateful for modern medicine.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about stavudine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of stavudine?

"The following are symptoms of nerve damage: weakness, numbness, tingling, or burning pain in your hands or feet; nausea, vomiting, diarrhea; rash; or headache."

Answered by AI

Is stavudine an antiviral medication?

"Stavudine is antiviral medicine that is used to treat human immunodeficiency virus (HIV). It can also be used to treat acquired immunodeficiency syndrome (AIDS). However, stavudine is not a cure for either HIV or AIDS. It may also be used for other purposes not mentioned in this guide."

Answered by AI

What is stavudine used for?

"Stavudine is a medication used to treat human immunodeficiency virus (HIV) infection, which is a virus that weakens the immune system and can lead to acquired immunodeficiency syndrome (AIDS). Stavudine is classified as a nucleoside reverse transcriptase inhibitor (NRTI), and it works by decreasing the amount of HIV in the blood."

Answered by AI

Why is stavudine no longer used?

"Although stavudine has similar antiretroviral activity as zidovudine, the significant toxicities associated with stavudine use (e.g. peripheral neuropathy, hyperlactatemia, lactic acidosis, hepatic steatosis, lipoatrophy, and pancreatitis) limit its clinical utility."

Answered by AI

Clinical Trials for Stavudine

Have you considered Stavudine clinical trials? We made a collection of clinical trials featuring Stavudine, we think they might fit your search criteria.
Have you considered Stavudine clinical trials? We made a collection of clinical trials featuring Stavudine, we think they might fit your search criteria.
Have you considered Stavudine clinical trials? We made a collection of clinical trials featuring Stavudine, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top