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What is Urocit-K
Potassium citrateThe Generic name of this drug
Treatment SummaryPotassium citrate, also known as tripotassium citrate, is a white, odorless powder with a salty taste. It is made up of 38.3% potassium. When mixed with water, it becomes highly hygroscopic and deliquescent. Potassium citrate is used to treat kidney stones and renal tubular acidosis. It is also used to manage a condition called hypocitraturic calcium oxalate nephrolithiasis.
Urocit-Kis the brand name
Urocit-K Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Urocit-K
Potassium citrate
1985
60
Approved as Treatment by the FDA
Potassium citrate, otherwise called Urocit-K, is approved by the FDA for 7 uses like Tubular Acidosis; Renal and uric acid lithiasis .Tubular Acidosis; Renal
Helps manage Tubular Acidosis; Renal
uric acid lithiasis
Helps manage uric acid lithiasis
uric acid
NEPHROLITHIASIS, CALCIUM OXALATE
Helps manage Hypocitraturic calcium oxalate nephrolithiasis
Nephrolithiasis
Renal tubular acidosis
Helps manage Tubular Acidosis; Renal
Lithiasis
Helps manage uric acid lithiasis
Effectiveness
How Urocit-K Affects PatientsPotassium citrate helps to prevent the formation of crystals and stones in the urine from salt compounds such as calcium oxalate, calcium phosphate and uric acid. It does this by increasing the citrate levels in the urine and binding with calcium, which decreases the activity of calcium ions and reduces the chances of calcium phosphate crystals forming. Additionally, it can stop the crystals from forming on their own.
How Urocit-K works in the bodyPotassium citrate, taken orally, breaks down in the body to form an alkaline load. This then increases the amount of citrate in urine and raises the pH level, while also increasing the potassium level. In some cases, this can lead to a decrease in the amount of calcium in the urine.
When to interrupt dosage
The suggested amount of Urocit-K is contingent upon the diagnosed condition, including Metabolic Acidosis, laxative and Renal tubular acidosis. The dosage varies as per the mode of administration (e.g. Solution - Oral or Liquid) stated in the table beneath.Condition
Dosage
Administration
Metabolic acidosis
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Uremia
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Constipation
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Renal tubular acidosis
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Bowel preparation therapy
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Kidney Stones
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Lithiasis
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
NEPHROLITHIASIS, CALCIUM OXALATE
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Gout Flares
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Nephrolithiasis
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Acidosis
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
uric acid
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
laxative
1100.0 mg/mL, , 550.0 mg/mL, 5.0 meq, 10.0 meq, 15.0 meq, 1080.0 mg, 3300.0 mg, 540.0 mg, 50.0 mg, 49.5 mg, 0.02 meq/mL, 19.5 mg/mL, 2.7 mg/mL, 2.17 mg/mL, 2.04 mg/mL, 282.0 mg, 847.0 mg, 20.0 mg/mL, 0.2 mg/mg, 6.25 mg, 5.0 mg, 5.4 mg, 40.0 mg, 0.5 mg/mL, 10.0 mg, 20.0 mg, 160.0 mg, 2.5 mg, 99.0 mg, 0.00148 mg/mg, 30.0 mg, 398.0 mg/mL, 975.0 mg, 1.193 mg/mg, 13.0 mg
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Granule, for solution, Granule, for solution - Oral, Liquid, Liquid - Oral, Syrup, Syrup - Oral, Powder, Powder - Oral, Capsule, Capsule - Oral, Tablet, effervescent, Tablet, effervescent - Oral
Warnings
Urocit-K ContraindicationsCondition
Risk Level
Notes
Hyperkalemia
Do Not Combine
Renal Insufficiency
Do Not Combine
Urinary tract infection
Do Not Combine
Gastrointestinal tract structure
Do Not Combine
Peptic Ulcer Disease
Do Not Combine
Common Urocit-K Drug Interactions
Drug Name
Risk Level
Description
2,5-Dimethoxy-4-ethylamphetamine
Major
The excretion of 2,5-Dimethoxy-4-ethylamphetamine can be decreased when combined with Potassium citrate.
2,5-Dimethoxy-4-ethylthioamphetamine
Major
The excretion of 2,5-Dimethoxy-4-ethylthioamphetamine can be decreased when combined with Potassium citrate.
4-Bromo-2,5-dimethoxyamphetamine
Major
The excretion of 4-Bromo-2,5-dimethoxyamphetamine can be decreased when combined with Potassium citrate.
Albutrepenonacog alfa
Major
The therapeutic efficacy of Albutrepenonacog alfa can be decreased when used in combination with Potassium citrate.
Amiloride
Major
The risk or severity of hyperkalemia can be increased when Potassium citrate is combined with Amiloride.
Urocit-K Toxicity & Overdose RiskThe toxic dose of the drug for dogs is 176mg/kg when administered intravenously.
Urocit-K Novel Uses: Which Conditions Have a Clinical Trial Featuring Urocit-K?
A total of 74 active clinical trials are assessing the potential of Urocit-K to provide Bowel preparation therapy, Kidney Stone Dissolution and Chronic Constipation Relief.Condition
Clinical Trials
Trial Phases
Kidney Stones
41 Actively Recruiting
Not Applicable, Early Phase 1, Phase 4, Phase 2
Constipation
14 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3
Bowel preparation therapy
1 Actively Recruiting
Phase 1, Phase 2
Metabolic acidosis
0 Actively Recruiting
NEPHROLITHIASIS, CALCIUM OXALATE
0 Actively Recruiting
Gout Flares
0 Actively Recruiting
Nephrolithiasis
0 Actively Recruiting
Lithiasis
0 Actively Recruiting
uric acid
1 Actively Recruiting
Phase 4
Acidosis
0 Actively Recruiting
Uremia
0 Actively Recruiting
Renal tubular acidosis
0 Actively Recruiting
laxative
0 Actively Recruiting
Urocit-K Reviews: What are patients saying about Urocit-K?
4.7Patient Review
3/11/2013 I took this for around eight months while I was deployed to Afghanistan. It was great because it's hard to diet there, and I had no side effects or stones. But then I got lazy and stopped taking it for a couple months, and that resulted in a small stone. So now I'm back on the medication again.
4Patient Review
3/3/2009 I'm not usually one for taking medication, but this has been a lifesaver. I've been kidney stone free for almost two years now, and it's all thanks to this little pill. They're tough to swallow (literally), but I know it's worth it.
3.7Patient Review
12/30/2008 The pills are large and not coated, making them hard to swallow. I've only just started taking the medication so I can't speak to its efficacy yet.
3Patient Review
1/23/2010 I've only been on this medication for a week, but I have experienced significant heartburn relief. Additionally, this week I passed five kidney stones.
2.7Patient Review
2/1/2009 I take it with meals to avoid the upset stomach that it sometimes causes. I use cold juice to help it go down. When I take it regularly, it seems to decrease the frequency of kidney stones (with the drug: one stone every ~10 yrs; without the drug: one stone every ~5 yrs).
Patient Q&A Section about urocit-k
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Urocit-K the same as potassium citrate?
"Potassium citrate alters the pH of urine, making it less acidic. This allows the kidneys to excrete uric acid more efficiently, reducing the risk of kidney stones."
Answered by AI
What is Urocit-K used for?
"This medication is used in order to make the urine less acidic. The purpose of this is to help the kidneys get rid of uric acid, which also helps to prevent gout and kidney stones. This medication can also be used to prevent and treat certain metabolic problems (acidosis) that are caused by kidney disease."
Answered by AI
What are the side effects of Urocit-K?
"You may experience some side effects when taking potassium citrate, including nausea, vomiting, diarrhea, stomach pain or upset, or the appearance of a potassium citrate tablet in your stool."
Answered by AI
Is Urocit-K over the counter?
"Urocit-K is a prescription medication that helps to prevent kidney stones by restoring the chemical balance in the kidneys. It is available in three different dosage strengths, and reduces the formation of several common types of kidney stones, including calcium oxalate and uric acid stones."
Answered by AI