Your session is about to expire
← Back to Search
Vitamin D Analog
Calcipotriol as a Novel Treatment for Central Centrifugal Cicatricial Alopecia (CCCA) (CCCA Trial)
Phase < 1
Waitlist Available
Led By Amy McMichael, MD
Research Sponsored by Wake Forest University Health Sciences
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up month 2, month 4, and month 6
Awards & highlights
All Individual Drugs Already Approved
Summary
This trial is testing calcipotriol, a vitamin D-like cream, on patients with CCCA. These patients often have low vitamin D levels. The cream may help by reducing inflammation and supporting immune health around hair follicles. Calcipotriol has been studied for its effectiveness in treating conditions like psoriasis and alopecia areata.
Eligible Conditions
- Central Centrifugal Cicatricial Alopecia
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ month 2, month 4, and month 6
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~month 2, month 4, and month 6
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Amount of hairline stabilization
Secondary study objectives
Amount of hair regrowth
Dermatology Life Quality Index score
Signs and symptoms of disease score
Side effects data
From 2010 Phase 3 trial • 1245 Patients • NCT006910027%
Psoriasis
3%
Headache
2%
Pruritus
2%
Erythema
2%
Nasopharyngitis
1%
Pyrexia
1%
Herpes simplex
1%
Skin irritation
1%
Rhinitis
1%
Diarrhoea
1%
Toothache
1%
Application site pruritus
1%
Influenza
1%
Burning sensation
100%
80%
60%
40%
20%
0%
Study treatment Arm
LEO 80190
Calcipotriol
Hydrocortisone
LEO 80190 Vehicle
Open-label Phase
Awards & Highlights
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Trial Design
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Calcipotriol GroupExperimental Treatment1 Intervention
Subjects will use the topical formulation once daily on the scalp. The subjects will use the treatment for a total of 6 months.
Group II: Control GroupPlacebo Group1 Intervention
Subjects will continue to use their primary physician prescribed topical formulation once daily on the scalp. The subjects will use their treatment for a total of 6 months.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Calcipotriol
FDA approved
Find a Location
Who is running the clinical trial?
Wake Forest University Health SciencesLead Sponsor
1,397 Previous Clinical Trials
2,460,129 Total Patients Enrolled
Amy McMichael, MDPrincipal InvestigatorWake Forest University Health Sciences
6 Previous Clinical Trials
233 Total Patients Enrolled