[18F]UCB-2897 for Overactive Bladder

Phase 1

Waitlist Available

Led By David Russell, MD, Ph.D

Research Sponsored by Invicro

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up screening, pre-injection, and at the completion of imaging

Awards & highlights

No Placebo-Only Group

Summary

This trial uses a special substance to detect specific brain proteins in people with Parkinson's Disease, Multiple System Atrophy, and healthy volunteers. The substance binds to these proteins and is visible on a scan, helping doctors understand protein presence in the brain.

Eligible Conditions

Shy-Drager syndrome
Overactive Bladder
Parkinson's Disease
Healthy Subjects

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ [18f]ucb-2897 pet imaging visit

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~[18f]ucb-2897 pet imaging visit

This trial's timeline: 3 weeks for screening, Varies for treatment, and [18f]ucb-2897 pet imaging visit for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Quantitative analysis of [18F]UCB-2897 brain PET scans

Safety Outcome Measures

Whole-body Biodistribution Outcome Measures

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: [18F]UCB-2897Experimental Treatment1 Intervention

Administration of Investigational Agent: Study center personnel will administer \[18F\]UCB-2897 as an IV injection. Prior to PET imaging, participants will have an IV catheter (for radiopharmaceutical administration) inserted according to standard clinical practice. Each participant will receive a single injection of \[18F\]UCB-2897. \[18F\]UCB-2897 will be injected IV at a dose of not more than 10 mCi, with a maximum mass dose of 10 μg and maximum volume of 10 mL. The injection will be followed by a 10 mL saline flush. Qualified study staff will accompany participants during PET imaging procedures.

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