Gentle Moves for Mild Cognitive Impairment and Dementia (Pro-Home MeC Trial)
Recruiting in Palo Alto (17 mi)
Age: 18+
Sex: Any
Travel: May be covered
Time Reimbursement: Varies
Trial Phase: Phase 1
Waitlist Available
Sponsor: University of Illinois at Chicago
No Placebo Group
Trial Summary
What is the purpose of this trial?The objective of the proposed study, "Promoting In-Home Activities at a Memory \& Aging Clinic (Pro-Home MeC)", is to assess and improve the feasibility of a physical activity (PA) intervention and the measurement of cognitive outcomes in a memory clinic setting for inactive older adults with mild cognitive impairment (MCI) or mild dementia and to examine how and improve the feasibility and acceptability of the procedures.
Do I need to stop taking my current medications to join the trial?
The trial protocol does not specify whether you need to stop taking your current medications.
Is Gentle Moves a promising treatment for mild cognitive impairment and dementia?
Gentle Moves could be a promising treatment because exercise and movement therapies have shown potential benefits for people with mild cognitive impairment and dementia. These therapies can help improve quality of life, balance, and social engagement, which are important for people with these conditions.
4781011What safety data exists for Gentle Moves in treating mild cognitive impairment and dementia?
The research provided does not directly address the safety data for Gentle Moves specifically. However, it includes studies on dance movement interventions and exercise routines for individuals with mild cognitive impairment and dementia, which are related to Gentle Moves. These studies suggest that such interventions are feasible and may improve cognitive function and promote activity and independence, but specific safety data for Gentle Moves is not detailed in the provided research.
125712What data supports the idea that Gentle Moves for Mild Cognitive Impairment and Dementia is an effective treatment?
The available research shows that exercise and activity-based treatments can be beneficial for people with mild cognitive impairment and dementia. For example, a study on a similar exercise program found that participants improved in their ability to stand on one leg and complete a simple walking test, which are indicators of better balance and mobility. This suggests that exercise programs like Gentle Moves could help improve physical abilities in people with these conditions. However, the research does not provide specific data on Gentle Moves itself, so more studies are needed to confirm its effectiveness.
367911Eligibility Criteria
This trial is for people aged 50 or older who speak English and have been diagnosed with mild cognitive impairment (MCI) or mild dementia. They should be physically inactive, doing less than 150 minutes of planned exercise per week, and able to sit independently for at least 15 minutes. Those with significant mental or physical disabilities, severe hearing or vision loss, insufficient decision-making capacity, lack of safety awareness, current participation in similar research, or unwillingness to be assigned randomly can't join.Participant Groups
The 'Pro-Home MeC' study tests a physical activity program called 'Gentle Moves' designed for older adults with MCI or mild dementia in a memory clinic setting. The goal is to see if the program is doable and liked by participants while also checking its effect on brain function.
2Treatment groups
Experimental Treatment
Active Control
Group I: Gentle MovesExperimental Treatment1 Intervention
Three-month physical activity intervention.
Group II: Usual CareActive Control1 Intervention
Usual care provided by neuropsychologist.
Find A Clinic Near You
Research locations nearbySelect from list below to view details:
Naoko MuramatsuChicago, IL
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Who is running the clinical trial?
University of Illinois at ChicagoLead Sponsor
National Institute on Aging (NIA)Collaborator
References
Motor function in subjects with mild cognitive impairment and early Alzheimer's disease. [2022]Basic mobility, balance, gait and dual-task performance were characterised in 140 consecutive subjects referred to a multidisciplinary university hospital in a geriatric setting for cognitive symptoms and possible dementia. After completion of an extensive diagnostic evaluation, subjects were classified into four diagnostic categories: no cognitive impairment, mild cognitive impairment, Alzheimer's disease (AD) and other dementia. Mean age was 57 +/- 9.2, 60 +/- 7.3, 68 +/- 9.9 and 64 +/- 10.5, respectively. Data on motor function, medication use and presence of white matter changes were evaluated and compared between the diagnostic groups. Motor function seems to be affected in very mild AD but not in mild cognitive impairment, as assessed with performance-based tests. AD subjects were slowed and had difficulties in dual-task performance requiring concurrently performing a cognitive task while walking.
Assessment of balance in mild and moderate stages of Alzheimer's disease: implications on falls and functional capacity. [2022]To analyze the correlation between balance, falls and loss of functional capacity in mild and moderate Alzheimer's disease(AD).
Fall risk-relevant functional mobility outcomes in dementia following dyadic tai chi exercise. [2022]Whether persons with dementia benefit from fall prevention exercise is unclear. Applying the Positive Emotion-Motivated Tai Chi protocol, preliminary findings concerning adherence and effects of a dyadic Tai Chi exercise program on persons with Alzheimer's disease (AD) are reported. Using pre/posttest design, 22 community-dwelling AD-caregiver dyads participated in the program. Fall-risk-relevant functional mobility was measured using Unipedal Stance Time (UST) and Timed Up and Go (TUG) tests. Results showed that 19/22 (86.4%) AD patients completed the 16-week program and final assessment; 16/19 dyads (84.2%) completed the prescribed home program as reported by caregivers. UST adjusted mean improved from 4.0 to 5.1 (Week 4, p .05) post intervention. Retaining dementia patients in an exercise intervention remains challenging. The dyadic Tai Chi approach appears to succeed in keeping AD-caregiver dyads exercising and safe.
The effects of the music-with-movement intervention on the cognitive functions of people with moderate dementia: a randomized controlled trial. [2022]The aim of this study was to examine the effects of the six-week music-with-movement (MM) intervention, as compared with music listening (ML) and social activity (SA), on the cognitive functions of people with moderate dementia over time.
Effects of a specially designed aerobic dance routine on mild cognitive impairment. [2022]Mild cognitive impairment (MCI) is known as a transitional stage or phase between normal aging and dementia. In addition, it is associated with an increased risk of dementia. Research has shown that moderate-intensity exercise is associated with a decreased risk of cognitive impairment. Two recent studies demonstrated that dance interventions are associated with improved cognitive function in the elderly with MCI.
Pilot feasibility study of a home-based fall prevention exercise program (StandingTall) delivered through a tablet computer (iPad) in older people with dementia. [2022]To assess the feasibility and safety of StandingTall-an individually tailored, progressive exercise program delivered through tablet computers-in community-dwelling older people with dementia.
A randomised controlled trial of an exercise intervention promoting activity, independence and stability in older adults with mild cognitive impairment and early dementia (PrAISED) - A Protocol. [2021]People with dementia progressively lose cognitive and functional abilities. Interventions promoting exercise and activity may slow decline. We developed a novel intervention to promote activity and independence and prevent falls in people with mild cognitive impairment (MCI) or early dementia. We successfully undertook a feasibility randomised controlled trial (RCT) to refine the intervention and research delivery. We are now delivering a multi-centred RCT to evaluate its clinical and cost-effectiveness.
The relative effectiveness of different types of exercise for people with Mild Cognitive Impairment or dementia: Systematic review protocol. [2021]To investigate which type of exercise is the most effective for people with mild cognitive impairment (MCI) or dementia.
Does physical exercise improve the capacity for independent living in people with dementia or mild cognitive impairment: an overview of systematic reviews and meta-analyses. [2023]To summarise existing systematic reviews which assessed the effects of physical exercise on activities of daily living, walking, balance and visual processing in people with dementia or mild cognitive impairment.
Improvisational Movement to Improve Quality of Life in Older Adults With Early-Stage Dementia: A Pilot Study. [2022]Alzheimer's disease has profound effects on quality of life, affecting not only cognition, but mobility and opportunities for social engagement. Dance is a form of movement that may be uniquely suited to help maintain quality of life for older adults, including those with dementia, because it inherently incorporates movement, social engagement, and cognitive stimulation. Here, we describe the methods and results of the pilot study for the IMOVE trial (NCT03333837, www.clinicaltrials.gov), a clinical trial designed to use improvisational dance classes to test the effects of movement and social engagement in people with mild cognitive impairment (MCI) or early-stage dementia. The pilot study was an 8-week investigation into the feasibility and potential effects of an improvisational dance intervention on people with MCI or early-stage dementia (PWD/MCI) and their caregivers (CG). The pilot aimed to assess changes in quality of life, balance, mood, and functional brain networks in PWD/MCI and their CG. Participants were recruited as dyads (pairs) that included one PWD/MCI and one CG. Ten total dyads were enrolled in the pilot study with five dyads assigned to the usual care control group and five dyads participating in the dance intervention. The intervention arm met twice weekly for 60 min for 8 weeks. Attendance and quality of life assessed with the Quality of Life in Alzheimer's disease (QoL-AD) questionnaire were the primary outcomes. Secondary outcomes included balance, mood and brain network connectivity assessed through graph theory analysis of functional magnetic resonance imaging (fMRI). Class attendance was 96% and qualitative feedback reflected participants felt socially connected to the group. Increases in quality of life and balance were observed, but not mood. Brain imaging analysis showed increases in multiple brain network characteristics, including global efficiency and modularity. Further investigation into the positive effects of this dance intervention on both imaging and non-imaging metrics will be carried out on the full clinical trial data. Results from the trial are expected in the summer of 2022.
Promoting Activity, Independence, and Stability in Early Dementia and mild cognitive impairment (PrAISED): randomised controlled trial. [2023]To determine the effectiveness of an exercise and functional activity therapy intervention in adults with early dementia or mild cognitive impairment compared with usual care.
The effectiveness of dance movement interventions for older adults with mild cognitive impairment, Alzheimer's disease, and dementia: A systematic scoping review and meta-analysis. [2023]To synthesize evidence and summarize research findings related to the effectiveness and feasibility of dance movement intervention (DMI) in older adults with mild cognitive impairment (MCI), Alzheimer's disease (AD), and dementia; to systemically map existing research gaps and research directions for future practice.