Trial Summary
What is the purpose of this trial?
The purpose of this study is to determine how safe and how well-tolerated the experimental study drug, C134 is when re-administered into the brain where the tumor is located.
Eligibility Criteria
This trial is for individuals with recurrent glioblastoma or similar brain tumors. Participants should have a tumor that has returned after previous treatment and be in good enough health to receive the experimental therapy directly into their brain.Inclusion Criteria
My blood tests show my organs are functioning well.
I agree to use birth control during and 6 months after the study due to unknown effects of C134.
I am 18 years old or older.
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Exclusion Criteria
Patients may not be receiving any other investigational agents (except C134 per protocol).
Enhancing tumor diameter larger than 5.5 cm
I have had severe allergic reactions to C134 or similar drugs.
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Treatment Details
Interventions
- C134 (Virus Therapy)
Trial OverviewThe study is testing the safety and tolerability of an experimental drug called C134, which will be administered again directly to the site of the brain tumor.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: Recurrent Malignant GliomaExperimental Treatment1 Intervention
Participants that have completed the study "Trial of C134 in Patients With Recurrent GBM (C134-HSV-1)"
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
University of Alabama at BirminghamBirmingham, AL
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Who Is Running the Clinical Trial?
University of Alabama at BirminghamLead Sponsor