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Tyrosine Kinase Inhibitor

TPX-0131 for Non-Small Cell Lung Cancer

Phase 1
Waitlist Available
Research Sponsored by Turning Point Therapeutics, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up approximately 34 months
Awards & highlights

Summary

This trial is testing a new drug to treat patients with lung cancer that has progressed or spread, and who have a specific genetic change (ALK+). The trial will assess the safety and effectiveness of the drug.

Eligible Conditions
  • Non-Small Cell Lung Cancer
  • Solid Tumors
  • Metastatic Tumor
  • Gene Mutation

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~approximately 34 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and approximately 34 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Define the Recommended Phase 2 Dose
Incidence of first cycle dose-limiting toxicities (DLTs) of TPX-0131
Secondary outcome measures
Adverse events (AEs)

Trial Design

1Treatment groups
Experimental Treatment
Group I: TPX-0131Experimental Treatment1 Intervention
The Phase 1 part of the study will determine the safety, tolerability, PK, MTD, and RP2D of TPX-0131.

Find a Location

Who is running the clinical trial?

Turning Point Therapeutics, Inc.Lead Sponsor
9 Previous Clinical Trials
866 Total Patients Enrolled
Eric Park, M.D.Study DirectorTurning Point Therapeutics
1 Previous Clinical Trials
90 Total Patients Enrolled
Turning Point Therapeutics, MDStudy DirectorTurning Point Therapeutics
3 Previous Clinical Trials
125 Total Patients Enrolled
~3 spots leftby Sep 2025
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