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Vancomycin-Soaked Mesh for Open Hernia Repair

Phase 2 & 3
Waitlist Available
Research Sponsored by University of Saskatchewan
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Open ventral or inguinal hernia repair
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

Study Summary

This trial found that soaking meshes in a vancomycin solution just prior to their use in open hernia repairs will decrease rates of mesh infection.

Who is the study for?
This trial is for individuals undergoing open ventral or inguinal hernia repair surgery. It's not suitable for those who are having non-ventral or non-inguinal hernia repairs, or those whose procedure will be done laparoscopically.Check my eligibility
What is being tested?
The study is testing if soaking the mesh in vancomycin (an antibiotic) before using it in open hernia repair surgeries can reduce infection rates compared to using plain mesh without antibiotic treatment.See study design
What are the potential side effects?
Potential side effects may include local reactions at the surgery site related to vancomycin, such as redness, pain, or swelling. There could also be a risk of allergic reactions to the antibiotic.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am having or had an open hernia repair surgery.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
mesh infections
Secondary outcome measures
hernia recurrence
postoperative seroma formation

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: vancomycin-soaked meshExperimental Treatment1 Intervention
use of vancomycin-soaked mesh for open hernia repair
Group II: plain meshActive Control1 Intervention
standard practice of using plain mesh (non vancomycin-soaked) for open hernia repair

Find a Location

Who is running the clinical trial?

University of SaskatchewanLead Sponsor
251 Previous Clinical Trials
154,156 Total Patients Enrolled

Media Library

Plain Mesh Clinical Trial Eligibility Overview. Trial Name: NCT01860469 — Phase 2 & 3
Open Hernia Repair Research Study Groups: plain mesh, vancomycin-soaked mesh
Open Hernia Repair Clinical Trial 2023: Plain Mesh Highlights & Side Effects. Trial Name: NCT01860469 — Phase 2 & 3
Plain Mesh 2023 Treatment Timeline for Medical Study. Trial Name: NCT01860469 — Phase 2 & 3
~29 spots leftby Jun 2025
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