Phase 1b/2 Study of Futibatinib in Combination With Binimetinib in Patients With Advanced KRAS Mutant Cancer
Recruiting in Palo Alto (17 mi)
+2 other locations
Age: 18+
Sex: Any
Travel: May be covered
Time Reimbursement: Varies
Trial Phase: Phase 1
Waitlist Available
Sponsor: Taiho Oncology, Inc.
No Placebo Group
Breakthrough Therapy
Trial Summary
What is the purpose of this trial?Phase 1b/2 study to evaluate the FGFRi futibatinib in combination with the MEKi binimetinib in patients with advanced KRASmt tumors.
Eligibility Criteria
Participant Groups
1Treatment groups
Experimental Treatment
Group I: Futibitanib in combination with binimetinibExperimental Treatment1 Intervention
Dose escalation: Futibitanib in combination with binimetinib in patients with advanced cancer disease.
Dose expansion: Futibatinib in combination with binimetinib at the RP2D in patients with advanced KRASmt NSCLC
Binimetinib is already approved in United States, European Union, Canada, Japan for the following indications:
🇺🇸 Approved in United States as Mektovi for:
- Unresectable or metastatic melanoma with a BRAF V600E or V600K mutation
🇪🇺 Approved in European Union as Mektovi for:
- Unresectable or metastatic melanoma with a BRAF V600 mutation
🇨🇦 Approved in Canada as Mektovi for:
- Unresectable or metastatic melanoma with a BRAF V600E or V600K mutation
🇯🇵 Approved in Japan as Mektovi for:
- Unresectable or metastatic melanoma with a BRAF V600 mutation
Find A Clinic Near You
Research locations nearbySelect from list below to view details:
University of California Los Angeles UCLA CancerSanta Monica, CA
Community Cancer Center NorthIndianapolis, IN
The University of Texas MD Anderson Cancer CenterHouston, TX
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Who is running the clinical trial?
Taiho Oncology, Inc.Lead Sponsor